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==Historical Perspective==
==Historical Perspective==
EV68 caused [[pneumonia]] and [[bronchiolitis]] in four children in California in 1962.<ref name="Schieble-1967">{{Cite journal  | last1 = Schieble | first1 = JH. | last2 = Fox | first2 = VL. | last3 = Lennette | first3 = EH. | title = A probable new human picornavirus associated with respiratory diseases. | journal = Am J Epidemiol | volume = 85 | issue = 2 | pages = 297-310 | month = Mar | year = 1967 | doi =  | PMID = 4960233 }}</ref> EV68 has been isolated ten times, the most recent of which is in 2014. The other isolations were in the years 1970, 1987, 1994, 1997, 2000 and 2003.<ref name="Khetsuriani-2006">{{Cite journal | last1 = Khetsuriani | first1 = N. | last2 = Lamonte-Fowlkes | first2 = A. | last3 = Oberst | first3 = S. | last4 = Pallansch | first4 = MA. | title = Enterovirus surveillance--United States, 1970-2005. | journal = MMWR Surveill Summ | volume = 55 | issue = 8 | pages = 1-20 | month = Sep | year = 2006 | doi | PMID = 16971890 }}</ref>
Human enterovirus 68 (EV-D68) was initially detected in 1962 from samples of 4 children presenting for [[pneumonia]] and [[bronchiolitis]] at a hospital in California.<ref name="Schieble-1967">{{Cite journal  | last1 = Schieble | first1 = JH. | last2 = Fox | first2 = VL. | last3 = Lennette | first3 = EH. | title = A probable new human picornavirus associated with respiratory diseases. | journal = Am J Epidemiol | volume = 85 | issue = 2 | pages = 297-310 | month = Mar | year = 1967 | doi =  | PMID = 4960233 }}</ref> Prior to 2005, reports of enterovirus 68 infections were very limited. Only 26 cases of verified EV-D68 infection were documented between 1970 and 2005. This represents 0.1% of all enterovirus isolates in that time frame, one of the rarest infectious enteroviruses. Over the past couple of years, outbreaks of EV-D68 have been documented in Japan, the Philippines and the Netherlands, as well as several clusters in the USA.<ref name="pmid22694903">{{cite journal| author=Tokarz R, Firth C, Madhi SA, Howie SR, Wu W, Sall AA et al.| title=Worldwide emergence of multiple clades of enterovirus 68. | journal=J Gen Virol | year= 2012 | volume= 93 | issue= Pt 9 | pages= 1952-8 | pmid=22694903 | doi=10.1099/vir.0.043935-0 | pmc=PMC3542132 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22694903 }} </ref> The most recent of these outbreaks occurred in late August and September of 2014 with clusters reported in 10 states including Colorado, North Carolina, Georgia, Ohio, Iowa, Illinois, Missouri, Kansas, Oklahoma and Kentucky.
 


==References==
==References==

Revision as of 16:32, 9 September 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Historical Perspective

Human enterovirus 68 (EV-D68) was initially detected in 1962 from samples of 4 children presenting for pneumonia and bronchiolitis at a hospital in California.[1] Prior to 2005, reports of enterovirus 68 infections were very limited. Only 26 cases of verified EV-D68 infection were documented between 1970 and 2005. This represents 0.1% of all enterovirus isolates in that time frame, one of the rarest infectious enteroviruses. Over the past couple of years, outbreaks of EV-D68 have been documented in Japan, the Philippines and the Netherlands, as well as several clusters in the USA.[2] The most recent of these outbreaks occurred in late August and September of 2014 with clusters reported in 10 states including Colorado, North Carolina, Georgia, Ohio, Iowa, Illinois, Missouri, Kansas, Oklahoma and Kentucky.

References

  1. Schieble, JH.; Fox, VL.; Lennette, EH. (1967). "A probable new human picornavirus associated with respiratory diseases". Am J Epidemiol. 85 (2): 297–310. PMID 4960233. Unknown parameter |month= ignored (help)
  2. Tokarz R, Firth C, Madhi SA, Howie SR, Wu W, Sall AA; et al. (2012). "Worldwide emergence of multiple clades of enterovirus 68". J Gen Virol. 93 (Pt 9): 1952–8. doi:10.1099/vir.0.043935-0. PMC 3542132. PMID 22694903.