Endometrial cancer classification: Difference between revisions

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* Type II
* Type II
{| class="wikitable"
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Histology
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prognosis
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pathogenesis
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prevalence
|-
| style="background:#DCDCDC;" align="center" + |Type I
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
| style="background:#F5F5F5;" align="center" + |*May arise from atypical hyperplasia// *Linked to unopposed estrogen stimulation
| style="background:#F5F5F5;" align="center" + |80%
|-
| style="background:#DCDCDC;" align="center" + |Type II
| style="background:#F5F5F5;" align="center" + |*Endometroid *Serous *Clear cell *Mucinous *Squamous *Mesonephric *Undifferentiated
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
| style="background:#F5F5F5;" align="center" + |*Develops from atrophic endometrium </br> *Not linked to hormonally driven pathogenesis
| style="background:#F5F5F5;" align="center" + |15-20%
|}





Revision as of 18:07, 26 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:

  • Type I
  • Type II
Type Histology Prognosis Pathogenesis Prevalence
Type I Endometroid (adenocarcinoma) Favorable (estrogen-responsive) *May arise from atypical hyperplasia// *Linked to unopposed estrogen stimulation 80%
Type II *Endometroid *Serous *Clear cell *Mucinous *Squamous *Mesonephric *Undifferentiated Typically bad prognosis *Develops from atrophic endometrium
*Not linked to hormonally driven pathogenesis
15-20%



Classification Based on Pathogenesis

  • Endometrial cancers are classified into either type 1 or type 2:[1]
  • Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
  • Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.

Classification Based on Histopathological Subtype

There are 7 subtypes of endometrial cancer based on histopathology:

1. Endometrioid (75%–80%)(The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements)
  • Ciliated adenocarcinoma
  • Secretory adenocarcinoma
  • Papillary or villoglandular
  • Adenocarcinoma with squamous differentiation
  • Adenoacanthoma
  • Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
2. Uterine papillary serous (<10%)
3. Mucinous (1%)
4. Clear cell (4%)
5. Squamous cell (<1%)
6. Mixed (10%)
7. Undifferentiated

References

  1. "endometrial cancer classification".


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