Elongation factor 2 kinase

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In enzymology, an elongation factor 2 kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [elongation factor 2] ADP + [elongation factor 2] phosphate

Thus, the two substrates of this enzyme are ATP and [[[elongation factor 2]]], whereas its two products are ADP and [[[elongation factor 2] phosphate]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[elongation factor 2] phosphotransferase. Other names in common use include Ca/CaM-kinase III, calmodulin-dependent protein kinase III, CaM kinase III, eEF2 kinase, eEF2K, EF2K, and STK19.


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  • Mitsui K, Brady M, Palfrey HC, Nairn AC (1993). "Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas". J. Biol. Chem. 268: 13422&ndash, 33. PMID 8514778.
  • Hincke MT, Nairn AC (Pt 3). "Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini". Biochem. J. 282: 877&ndash, 82. PMID 1372803. Check date values in: |date= (help)
  • Knebel A, Morrice N, Cohen P (2001). "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta". EMBO. J. 20: 4360&ndash, 9. PMID 11500363.
  • Sans MD, Xie Q, Williams JA (2004). "Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini". Biochem. Biophys. Res. Commun. 319: 144&ndash, 51. PMID 15158453.
  • Browne GJ, Finn SG, Proud CG (2004). "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398". J. Biol. Chem. 279: 12220&ndash, 31. PMID 14709557.
  • Ryazanov AG (2002). "Elongation factor-2 kinase and its newly discovered relatives". FEBS. Lett. 514: 26&ndash, 9. PMID 11904175.

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Gene Ontology (GO) codes