Ebola classification: Difference between revisions

Jump to navigation Jump to search
Line 34: Line 34:


==Classification==
==Classification==
=====''Zaïre Ebolavirus''=====
=====''Zaïre Ebolavirus''=====
*Among the five [[strains]], ''Zaïre Ebolavirus'' carries the highest [[mortality rate]].
*Among the five [[strains]], ''Zaïre Ebolavirus'' carries the highest [[mortality rate]].
Line 50: Line 48:


=====''Reston Ebolavirus''=====
=====''Reston Ebolavirus''=====
A [[virus]] of the [[genus]]  ''[[Ebolavirus]]'' is considered member of the [[species]] ''Reston virus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
*A [[virus]] of the [[genus]]  ''[[Ebolavirus]]'' is considered member of the [[species]] ''Reston virus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
*If its [[genome]] diverges from that of the prototype ''Reston [[virus]]'', the ''Reston virus'' variant Pennsylvania, by ≤10% at the [[nucleotide]] level.
:*If its [[genome]] diverges from that of the prototype ''Reston [[virus]]'', the ''Reston virus'' variant Pennsylvania, by ≤10% at the [[nucleotide]] level.


=====''Tai (Ivory Coast) Ebolavirus''=====
=====''Tai (Ivory Coast) Ebolavirus''=====
A [[virus]] of the genus ''[[Ebolavirus]]'' is a member of the [[species]] ''Tai Forest ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
*A [[virus]] of the genus ''[[Ebolavirus]]'' is a member of the [[species]] ''Tai Forest ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
* it is [[endemic]] in Côte d'Ivoire.
:* it is [[endemic]] in Côte d'Ivoire.
* it has a [[genome]] with three [[gene]] overlaps (''VP35''/''VP40'', ''GP''/''VP30'', ''VP24''/''L'').
:* it has a [[genome]] with three [[gene]] overlaps (''VP35''/''VP40'', ''GP''/''VP30'', ''VP24''/''L'').
* it has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30% but different from that of Tai Forest [[virus]] by <30%.
:* it has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30% but different from that of Tai Forest [[virus]] by <30%.


=====''Bundibugyo Ebolavirus''=====
=====''Bundibugyo Ebolavirus''=====
A virus of the genus ''[[Ebolavirus]]'' is a member of the species ''Bundibugyo ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
*A virus of the genus ''[[Ebolavirus]]'' is a member of the species ''Bundibugyo ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref>
:*It is [[endemic]] in Uganda.
:*It is [[endemic]] in Uganda.
:*It has a [[genome]] with three [[gene]] overlaps (''VP35''/''VP40'', ''GP''/''VP30'', ''VP24''/''L'').
:*It has a [[genome]] with three [[gene]] overlaps (''VP35''/''VP40'', ''GP''/''VP30'', ''VP24''/''L'').

Revision as of 02:16, 27 June 2014

Ebola Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ebola from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Algorithm for the Evaluation of the Returned Traveler

Emergency Department Evaluation

Case Definition

History and Symptoms

Physical Examination

Laboratory Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Hospital Preparedness

Checklists

Air Medical Transport

Monitoring and Movement Following Exposure

Primary Prevention

Future or Investigational Therapies

Postmortem Care

Postmortem Care

Case Studies

Case #1

Ebola classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ebola classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ebola classification

CDC on Ebola classification

Ebola classification in the news

Blogs on Ebola classification

Directions to Hospitals Treating ebola

Risk calculators and risk factors for Ebola classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Guillermo Rodriguez Nava, M.D. [2]; JS

Overview

Ebola virus can be classified in 5 subtypes: Zaïre, Sudan, Reston, Tai (Ivory Coast) and Bundibugyo.

The table below summarizes the ebola virus strains identified until now:

Ebola Virus Strain Place of Discovery Date Identified
Sudan ebolavirus Nzara and Maridi, Sudan Between June and November 1976
Zaire ebolavirus Yambuku, Democratic Republic of the Congo Between August and November 1976
Reston ebolavirus Reston, Virginia, US. November 1989
Ivory Coast ebolavirus Tai Forest, Ivory Coast. November 1994
Bundibugyo ebolavirus Bundibugyo District, Uganda November 2007

Classification

Zaïre Ebolavirus
  • It is found in the Democratic Republic of the Congo, Gabon, or the Republic of the Congo.
  • It has a genome with two or three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
  • It has a genomic sequence that differs from the type virus by less than 30%.
Sudan Ebolavirus
  • It is endemic in Sudan and/or Uganda.
  • It has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
  • It has a genomic sequence different from Ebola virus by ≥30%, but different from that of Sudan virus by <30%.
Reston Ebolavirus
  • If its genome diverges from that of the prototype Reston virus, the Reston virus variant Pennsylvania, by ≤10% at the nucleotide level.
Tai (Ivory Coast) Ebolavirus
  • it is endemic in Côte d'Ivoire.
  • it has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
  • it has a genomic sequence different from Ebola virus by ≥30% but different from that of Tai Forest virus by <30%.
Bundibugyo Ebolavirus
  • A virus of the genus Ebolavirus is a member of the species Bundibugyo ebolavirus if:[1]
  • It is endemic in Uganda.
  • It has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
  • It has a genomic sequence different from Ebola virus by ≥30%, but different from that of Bundibugyo virus by <30%.

References

  1. 1.0 1.1 1.2 1.3 1.4 Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I.; Netesov, Sergey V.; Nichol, Stuart T.; Palacios, Gustavo; Peters, Clarence J.; Tenorio, Antonio; Volchkov, Viktor E.; Jahrling, Peter B. (2010). "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. ISSN 0304-8608.


Template:WH Template:WS