ERCC excision repair 6 like, spindle assembly checkpoint helicase

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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ERCC excision repair 6 like, spindle assembly checkpoint helicase is a protein that in humans is encoded by the ERCC6L gene.

Function

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis.

Further reading

• Xu Y, Chen X, Li Y (2005). "Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol". Toxicol. Lett. 157 (3): 233–9. doi:10.1016/j.toxlet.2005.02.013. PMID 15917148.
• Baumann C, Körner R, Hofmann K, Nigg EA (2007). "PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint". Cell. 128 (1): 101–14. doi:10.1016/j.cell.2006.11.041. PMID 17218258.
• Spence JM, Phua HH, Mills W, Carpenter AJ, Porter AC, Farr CJ (2007). "Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads". J. Cell Sci. 120 (Pt 22): 3952–64. doi:10.1242/jcs.013730. PMC 5500177. PMID 17956945.
• Leng M, Bessuso D, Jung SY, Wang Y, Qin J (2008). "Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase". Cell Cycle. 7 (10): 1480–9. doi:10.4161/cc.7.10.5951. PMID 18418076.
• Hübner NC, Wang LH, Kaulich M, Descombes P, Poser I, Nigg EA (2010). "Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs". Chromosoma. 119 (2): 149–65. doi:10.1007/s00412-009-0244-2. PMC 2846388. PMID 19904549.
• Kurasawa Y, Yu-Lee LY (2010). "PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture". Mol. Biol. Cell. 21 (7): 1188–99. doi:10.1091/mbc.E09-11-0950. PMC 2847523. PMID 20130082.
• Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H (2011). "PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution". EMBO J. 30 (16): 3309–21. doi:10.1038/emboj.2011.226. PMC 3160651. PMID 21743438.
• Rouzeau S, Cordelières FP, Buhagiar-Labarchède G, Hurbain I, Onclercq-Delic R, Gemble S, Magnaghi-Jaulin L, Jaulin C, Amor-Guéret M (2012). "Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase". PLoS ONE. 7 (4): e33905. doi:10.1371/journal.pone.0033905. PMC 3338505. PMID 22563370.
• Biebricher A, Hirano S, Enzlin JH, Wiechens N, Streicher WW, Huttner D, Wang LH, Nigg EA, Owen-Hughes T, Liu Y, Peterman E, Wuite GJ, Hickson ID (2013). "PICH: a DNA translocase specially adapted for processing anaphase bridge DNA". Mol. Cell. 51 (5): 691–701. doi:10.1016/j.molcel.2013.07.016. PMC 4161920. PMID 23973328.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.