E2F3
| E2F transcription factor 3 | |||||||||||
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| Symbols | E2F3 ; DKFZp686C18211; E2F-3; KIAA0075; MGC104598 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 74413 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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E2F transcription factor 3, also known as E2F3, is a human gene.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[1]
See also
References
Further reading
- Nomura N, Nagase T, Miyajima N; et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. PMID 7584044.
- Wu CL, Zukerberg LR, Ngwu C; et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. PMID 7739537.
- Lees JA, Saito M, Vidal M; et al. (1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol. Cell. Biol. 13 (12): 7813–25. PMID 8246996.
- Karlseder J, Rotheneder H, Wintersberger E (1996). "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Mol. Cell. Biol. 16 (4): 1659–67. PMID 8657141.
- Rogers KT, Higgins PD, Milla MM; et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. PMID 8755520.
- Magae J, Wu CL, Illenye S; et al. (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". J. Cell. Sci. 109 ( Pt 7): 1717–26. PMID 8832394.
- Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. PMID 8846921.
- Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (1997). "The subcellular localization of E2F-4 is cell-cycle dependent". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. PMID 9144196.
- Dynlacht BD, Moberg K, Lees JA; et al. (1997). "Specific regulation of E2F family members by cyclin-dependent kinases". Mol. Cell. Biol. 17 (7): 3867–75. PMID 9199321.
- Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (1998). "Differential activities of E2F family members: unique functions in regulating transcription". Mol. Carcinog. 22 (3): 190–8. PMID 9688145.
- Humbert PO, Verona R, Trimarchi JM; et al. (2000). "E2f3 is critical for normal cellular proliferation". Genes Dev. 14 (6): 690–703. PMID 10733529.
- Takahashi Y, Rayman JB, Dynlacht BD (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes Dev. 14 (7): 804–16. PMID 10766737.
- Leone G, Nuckolls F, Ishida S; et al. (2000). "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins". Mol. Cell. Biol. 20 (10): 3626–32. PMID 10779352.
- He Y, Armanious MK, Thomas MJ, Cress WD (2000). "Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region". Oncogene. 19 (30): 3422–33. doi:10.1038/sj.onc.1203682. PMID 10918599.
- Yamochi T, Semba K, Tsuji K; et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. PMID 11733001.
- Weinmann AS, Yan PS, Oberley MJ; et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.
- Ren B, Cam H, Takahashi Y; et al. (2002). "E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints". Genes Dev. 16 (2): 245–56. doi:10.1101/gad.949802. PMID 11799067.
- He Y, Cress WD (2002). "E2F-3B is a physiological target of cyclin A.". J. Biol. Chem. 277 (26): 23493–9. doi:10.1074/jbc.M202629200. PMID 11980909.
- Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. PMID 12411495.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
External links
- E2F3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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