Dysfunctional uterine bleeding causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rinky Agnes Botleroo, M.B.B.S.

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Causes

Dysfunctional uterine bleeding means heavy uterine bleeding not due to any known causes and is therefore a diagnosis of exclusion. Other conditions such as uterine fibroids, endometrial polyps and systemic diseases should be excluded by appropriate investigations. In the adolescent, investigations for a coagulopathy should be performed. The pathophysiology of DUB is largely unknown but occurs in both ovulatory and anovulatory menstrual cycles. PALM-COEIN is a useful acronym provided by the International Federation of Obstetrics and Gynecology (FIGO) to classify the casuses of abnormal uterine bleeding. The first portion, PALM, describes anatomical issues. The second portion, COEI, describes non-structural issues. The N stands for "not otherwise classified."

P: Polyp
A: Adenomyosis
L: Leiomyoma
M: Malignancy and hyperplasia
C: Coagulopathy
O: Ovulatory dysfunction
E: Endometrial disorders
I: Iatrogenic
N: Not otherwise classified

Drug Side Effect

• Estradiol valerate and estradiol valerate/dienogest