Down syndrome epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Down syndrome}}
{{Down syndrome}}
{{CMG}}
{{CMG}}; {{AE}}{{HK}}
==Overview==
==Overview==
Down syndrome is the most common [[chromosomal]] abnormality. Each year approximately 3,000 to 5,000 children are born with this [[chromosome]] disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down Syndrome. [[Birth rate|Birth rates]] are highest among mothers of advanced [[maternal]] age however 80% of all children with Down syndrome are born to mothers younger than 35 years. Down syndrome occurs in people of all races and economic levels.
Down syndrome is the most common [[chromosomal]] abnormality. Each year approximately 3,000 to 5,000 children are born with this [[chromosome]] disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down syndrome. [[Birth rate|Birth rates]] are highest among mothers of advanced [[maternal]] age however 80% of all children with Down syndrome are born to mothers younger than 35 years. Down syndrome occurs in people of all races and economic levels.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
Line 13: Line 13:
=== Incidence ===
=== Incidence ===
* The estimated [[incidence]] of Down Syndrome is between 100 in 100,000 live births worldwide.<ref name="urlWHO | Genes and human disease">{{cite web |url=http://www.who.int/genomics/public/geneticdiseases/en/index1.html |title=WHO &#124; Genes and human disease |format= |work= |accessdate=}}</ref> 
* The estimated [[incidence]] of Down Syndrome is between 100 in 100,000 live births worldwide.<ref name="urlWHO | Genes and human disease">{{cite web |url=http://www.who.int/genomics/public/geneticdiseases/en/index1.html |title=WHO &#124; Genes and human disease |format= |work= |accessdate=}}</ref> 
* Each year approximately 3,000 to 5,000 children are born with this [[chromosome]] disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down Syndrome.<ref name="urlDown Syndrome Facts | National Down Syndrome Society">{{cite web |url=https://www.ndss.org/about-down-syndrome/down-syndrome-facts/ |title=Down Syndrome Facts &#124; National Down Syndrome Society |format= |work= |accessdate=}}</ref>
* Each year approximately 3,000 to 5,000 children are born with this [[chromosome]] disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down syndrome.<ref name="urlDown Syndrome Facts | National Down Syndrome Society">{{cite web |url=https://www.ndss.org/about-down-syndrome/down-syndrome-facts/ |title=Down Syndrome Facts &#124; National Down Syndrome Society |format= |work= |accessdate=}}</ref>


=== Maternal age ===
=== Maternal age ===

Latest revision as of 05:56, 21 March 2018

Down syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Down syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Sociological and Cultural Aspects

Case Studies

Case #1

Down syndrome epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Down syndrome epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Down syndrome epidemiology and demographics

CDC on Down syndrome epidemiology and demographics

Down syndrome epidemiology and demographics in the news

Blogs on Down syndrome epidemiology and demographics

Directions to Hospitals Treating Down syndrome

Risk calculators and risk factors for Down syndrome epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]

Overview

Down syndrome is the most common chromosomal abnormality. Each year approximately 3,000 to 5,000 children are born with this chromosome disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down syndrome. Birth rates are highest among mothers of advanced maternal age however 80% of all children with Down syndrome are born to mothers younger than 35 years. Down syndrome occurs in people of all races and economic levels.

Epidemiology and Demographics

Prevalence

  • Down syndrome is the most common chromosomal abnormality.
  • The prevalence of Down syndrome 691 live births, worldwide; prevalence of 100.3 per 100,000)[1]

Incidence

  • The estimated incidence of Down Syndrome is between 100 in 100,000 live births worldwide.[2] 
  • Each year approximately 3,000 to 5,000 children are born with this chromosome disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down syndrome.[3]

Maternal age

  • Birth rates are highest among mothers of advanced maternal age however 80% of all children with Down syndrome are born to mothers younger than 35 years.[4]
  • Maternal age influences the chances of conceiving a baby with Down syndrome. At maternal age 20 to 24, the probability is 1/1490; at age 40 the probability is 1/60, and at age 49 the probability is 1/11.[5] Although the probability increases with maternal age, 80% of children with Down syndrome are born to women under the age of 35,[6] reflecting the overall fertility of that age group. Recent data also suggest that paternal age also increases the risk of Down Syndrome manifesting in pregnancies in older mothers.[7]

Race

  • Down syndrome occurs in people of all races and economic levels.[8]

Gender

  • Down syndrome affects both genders equally.[9]

Prevalence of congenital malformations

  • Sixty to 80 percent of children with Down syndrome have hearing deficits. 
  • Forty to 45 percent of children with Down syndrome have congenital heart disease.
  • Intestinal abnormalities also occur at a higher frequency in children with Down syndrome. 
  • Children with Down Syndrome often have more eye problems than other children who do not have this chromosome disorder.


References

  1. Sherman SL, Allen EG, Bean LH, Freeman SB (2007). "Epidemiology of Down syndrome". Ment Retard Dev Disabil Res Rev. 13 (3): 221–7. doi:10.1002/mrdd.20157. PMID 17910090.
  2. "WHO | Genes and human disease".
  3. "Down Syndrome Facts | National Down Syndrome Society".
  4. "WHO | Genes and human disease".
  5. Hook, E.B. (1981). "Rates of chromosomal abnormalities at different maternal ages". Obstet Gynecol. 58: 282. PMID 6455611
  6. Estimate from "National Down Syndrome Center". Retrieved 2006-04-21.
  7. Warner, Jennifer. "Dad's Age Raises Down Syndrome Risk, Too", "WebMD Medical News". Retrieved 2007-09-29.
  8. "WHO | Genes and human disease".
  9. "WHO | Genes and human disease".

Template:WH Template:WS