Dopamine receptor D2
| Dopamine receptor D2 | |||||||||||
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| Symbols | DRD2 ; D2DR; D2R | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 22561 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Dopamine receptor D2, also known as DRD2, is a human gene.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia.[1] Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.[2]
See also
References
- ↑ Gene Overview of All Published Schizophrenia-Association Studies for DRD2 - Schizophrenia Research Forum SZGene database.
- ↑ "Entrez Gene: DRD2 dopamine receptor D2".
Further reading
- Missale C, Nash SR, Robinson SW; et al. (1998). "Dopamine receptors: from structure to function". Physiol. Rev. 78 (1): 189–225. PMID 9457173.
- Sidhu A, Niznik HB (2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". Int. J. Dev. Neurosci. 18 (7): 669–77. PMID 10978845.
- Araki K, Kuwano R, Morii K; et al. (1993). "Structure and expression of human and rat D2 dopamine receptor genes". Neurochem. Int. 21 (1): 91–8. PMID 1363862.
- Eubanks JH, Djabali M, Selleri L; et al. (1993). "Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23". Genomics. 14 (4): 1010–8. PMID 1478642.
- Dearry A, Falardeau P, Shores C, Caron MG (1992). "D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA". Cell. Mol. Neurobiol. 11 (5): 437–53. PMID 1835903.
- Sarkar G, Kapelner S, Grandy DK; et al. (1992). "Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor". Genomics. 11 (1): 8–14. PMID 1837284.
- Stormann TM, Gdula DC, Weiner DM, Brann MR (1990). "Molecular cloning and expression of a dopamine D2 receptor from human retina". Mol. Pharmacol. 37 (1): 1–6. PMID 2137193.
- Robakis NK, Mohamadi M, Fu DY; et al. (1990). "Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region". Nucleic Acids Res. 18 (5): 1299. PMID 2138729.
- Selbie LA, Hayes G, Shine J (1990). "DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype". Adv. Second Messenger Phosphoprotein Res. 24: 9–14. PMID 2144985.
- Monsma FJ, McVittie LD, Gerfen CR; et al. (1990). "Multiple D2 dopamine receptors produced by alternative RNA splicing". Nature. 342 (6252): 926–9. doi:10.1038/342926a0. PMID 2480527.
- Dal Toso R, Sommer B, Ewert M; et al. (1990). "The dopamine D2 receptor: two molecular forms generated by alternative splicing". EMBO J. 8 (13): 4025–34. PMID 2531656.
- Grandy DK, Marchionni MA, Makam H; et al. (1990). "Cloning of the cDNA and gene for a human D2 dopamine receptor". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9762–6. PMID 2532362.
- Selbie LA, Hayes G, Shine J (1990). "The major dopamine D2 receptor: molecular analysis of the human D2A subtype". DNA. 8 (9): 683–9. PMID 2533064.
- Leysen JE, Gommeren W, Mertens J; et al. (1995). "Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2'-iodospiperone". Psychopharmacology (Berl.). 110 (1–2): 27–36. PMID 7870895.
- Itokawa M, Arinami T, Futamura N; et al. (1994). "A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys)". Biochem. Biophys. Res. Commun. 196 (3): 1369–75. doi:10.1006/bbrc.1993.2404. PMID 7902708.
- Malmberg A, Jackson DM, Eriksson A, Mohell N (1993). "Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors". Mol. Pharmacol. 43 (5): 749–54. PMID 8099194.
- Seeman P, Ohara K, Ulpian C; et al. (1993). "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2". Neuropsychopharmacology. 8 (2): 137–42. PMID 8471125.
- Cravchik A, Sibley DR, Gejman PV (1996). "Functional analysis of the human D2 dopamine receptor missense variants". J. Biol. Chem. 271 (42): 26013–7. PMID 8824240.
- Ho MK, Wong YH (1997). "Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling". J. Neurochem. 68 (6): 2514–22. PMID 9166747.
External links
- Receptors,+Dopamine+D2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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