Disseminated intravascular coagulation history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Symptoms

Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications.

Bleeding Symptoms

• Petechiae
• Ecchymoses
• Blood oozing from wound sites, intravenous lines, catheters, mucosal surfaces
• Hemorrhage involving gastrointestinal tract, lungs, or central nervous system

Thrombosis Symptoms

• Venous thromboembolism
• Arterial thrombosis with tissue or organ ischemia
• Cerebral embolism

Organ Dysfunction

• Symptoms of acute kidney injury

• Decreased urinary output
• Edema
• Nausea
• Fatigue

• Symptoms of hepatic dysfunction

• Jaundice
• Nausea
• Abdominal pain and swelling

• Symptoms of acute lung injury

• Hemoptysis
• Dyspnea

• Symptoms of neurologic dysfunction

• Coma
• Delirium
• Focal neurologic deficits

• Symptoms of adrenal insufficiency

• Fatigue
• Nausea
• Low blood pressure
• Altered mental status