Disopyramide: Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
{{Disopyramide}}
|authorTag=
{{CMG}}; {{AE}} {{SS}}


'''''For patient information about Disopyramide, click [[Disopyramide (patient information)|here]].'''''


{{SB}} NORPACE<sup>®</sup>；NORPACE CR<sup>®</sup>；DISOPYRAMIDE PHOSPHATE<sup>®</sup>
<!--Overview-->


{|
|genericName=
|[[File:Disopyramide01.jpg|thumb|800px]]
|}


==Overview==


'''Disopyramide''' ([[International Nonproprietary Name|INN]], trade names '''Norpace''' and '''Rythmodan''') is an [[antiarrhythmic]] [[medication]] used in the treatment of Ventricular Tachycardia.<ref>Guyton, Arthur C., Hall, John E. (2006). Textbook of Medical Physiology (11th ed.). Philadelphia: Elsevier Saunders</ref> It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent.<ref>Rizos, I. I., et al. "Effects of Intravenous Disopyramide and Quinidine on Normal Myocardium and on the Characteristics of Arrhythmias: Intraindividual Comparison in Patients with Sustained Ventricular Tachycardia." European heart journal 8.2 (1987): 154-63. Biological Sciences. Web. 10 Feb. 2012</ref>’<ref>Kim, S. Y. SY, and N. L. NL Benowitz. "Poisoning due to Class IA Antiarrhythmic Drugs. Quinidine, Procainamide and Disopyramide." Drug safety : an international journal of medical toxicology and drug experience 5.6 (1990): 393-420. Biological Sciences; Environmental Science and Pollution Management. Web. 12 Feb. 2012.</ref> Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility.<ref>Levites, R. R., and G. J. GJ Anderson. "Electrophysiological Effects of Disopyramide Phosphate during Experimental Myocardial Ischemia." American Heart Journal 98.3 (1979): 339-44. Biological Sciences. Web. 15 Feb. 2012.</ref>'<ref>Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012</ref> Disopyramide also has an [[anticholinergic]] effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity.<ref>Mathur, P. P. PP. "Cardiovascular Effects of a Newer Antiarrhythmic Agent, Disopyramide Phosphate." American Heart Journal 84.6 (1972): 764-70. Biological Sciences; Environmental Science and Pollution Management. Web. 15 Feb. 2012</ref>


==Category==
|aOrAn=


[[Pyridines]];[[Sodium channel blockers]];[[Amides]];[[Cardiovascular Drugs]]
a


==FDA Package Insert==
|drugClass=


NORPACE (disopyramide phosphate) capsule, gelatin coated


====Label Title====


'''  [[Disopyramide indications and usage|Indications and Usage]]'''
|indication=
'''| [[Disopyramide dosage and administration|Dosage and Administration]]'''
'''| [[Disopyramide contraindications|Contraindications]]'''
'''| [[Disopyramide warnings and precautions|Warnings and Precautions]]'''
'''| [[Disopyramide adverse reactions|Adverse Reactions]]'''
'''| [[Disopyramide drug interactions|Drug Interactions]]'''
'''| [[Disopyramide use in specific populations|Use in Specific Populations]]'''
'''| [[Disopyramide overdosage|Overdosage]]'''
'''| [[Disopyramide description|Description]]'''
'''| [[Disopyramide clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Disopyramide nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Disopyramide how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Disopyramide labels and packages|Labels and Packages]]'''


==Mechanism of Action==


Norpace (disopyramide phosphate) is a Type 1 antiarrhythmic drug (i.e., similar to procainamide and quinidine). In animal studies Norpace decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors.


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[[Category:Antiarrhythmic agents]]
[[Category:Cardiovascular Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drug]]

Revision as of 18:47, 23 July 2014

Disopyramide
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Disopyramide is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Disopyramide in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Disopyramide in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Disopyramide in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Disopyramide in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Disopyramide in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Disopyramide in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Disopyramide in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Disopyramide in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Disopyramide during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Disopyramide with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Disopyramide with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Disopyramide with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Disopyramide with respect to specific gender populations.

Race

There is no FDA guidance on the use of Disopyramide with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Disopyramide in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Disopyramide in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Disopyramide in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Disopyramide in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Disopyramide in the drug label.

Condition1
  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Disopyramide in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Disopyramide in the drug label.

Pharmacology

There is limited information regarding Disopyramide Pharmacology in the drug label.

Mechanism of Action

Structure

File:Disopyramide01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Disopyramide in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Disopyramide in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Disopyramide in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Disopyramide in the drug label.

Condition1
  • Description

How Supplied

Storage

There is limited information regarding Disopyramide Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Disopyramide |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Disopyramide |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Disopyramide in the drug label.

Precautions with Alcohol

  • Alcohol-Disopyramide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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