Diphenhydramine: Difference between revisions

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{{drugbox
{{DrugProjectFormSinglePage
| IUPAC_name = 2-benzhydryloxy-''N'',''N''-dimethyl-ethanamine
|authorTag=<!--Overview-->
| image = Diphenhydramine_Structure.svg
|aOrAn=a
| CAS_number = 58-73-1
|hasBlackBoxWarning=Yes
| ATC_prefix = D04
|adverseReactions=<!--Black Box Warning-->
| ATC_suffix = AA32
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
| ATC_supplemental = {{ATC|D04|AA33}}, {{ATC|R06|AA02}}
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
| PubChem = 3100
 
| DrugBank = APRD00587
* Content
| C=17 | H=21 | N=1 | O=1
 
| molecular_weight = 255.355 g/mol
<!--Adult Indications and Dosage-->
| bioavailability = 86% bound to plasma protein
 
| protein_bound = 98 to 99%
<!--FDA-Labeled Indications and Dosage (Adult)-->
| metabolism = Various cytochrome P450 liver enzymes (cyp 2D6 (80%) ,cyp 3A4 (10%)<br />
|fdaLIADAdult======Condition1=====
| elimination_half-life = 2-8 hours
 
| pregnancy_category = B
* Dosing Information
| legal_status = Over-the-counter, non-regulated
 
| routes_of_administration = Oral, parenteral (IM), suppository
:* Dosage
| excretion = 94% through the urine, 6% through feces
 
}}
=====Condition2=====
{| border="1" cellpadding="3" cellspacing="0" width="250px" align="right" style="border-collapse: collapse; margin: 0 0 0 0.5em"
 
|-
* Dosing Information
|-
 
</table><table bgcolor="#ffffff" border="1" cellpadding="3" cellspacing="0" width="167px" align="right" style="border-collapse: collapse; clear: right; margin: 0 0 0 0.5em">
:* Dosage
|-
 
|'''Indicated for:'''<br/>
=====Condition3=====
* [[Antihistamine|Antihistaminic]]
 
* [[Motion sickness]]
* Dosing Information
* [[Sedative]]/[[Hypnotic]]
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
|offLabelAdultGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport======Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed======Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Off-Label Use and Dosage (Pediatric)-->
 
<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:  
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport======Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
|contraindications=* Condition1
 
<!--Warnings-->
|warnings=* Description
 
====Precautions====
 
* Description
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
 
=====Body as a Whole=====
 
 
 
 
=====Cardiovascular=====
 
 
 
 
=====Digestive=====
 
 
 
 
=====Endocrine=====
 
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
 
=====Metabolic and Nutritional=====
 
 
 
 
=====Musculoskeletal=====
 
 
 
 
=====Neurologic=====
 
 
 
 
=====Respiratory=====
 
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
 
=====Special Senses=====
 
 
 
 
=====Urogenital=====
 
 
 
 
=====Miscellaneous=====
 
 
 
<!--Postmarketing Experience-->
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
 
=====Body as a Whole=====
 
 
 
=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
=====Respiratory=====
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
=====Special Senses=====
 
 
 
=====Urogenital=====
 
 


'''Other uses:'''<br/>
=====Miscellaneous=====
* Halting allergic reactions, controlling [[extrapyramidal]] side-effects induced by [[antipsychotic]]s
|-
|'''[[Contraindication]]s:'''<br/>
* Use in neonates and premature infants
* Use in nursing mothers
* Use as a local anesthetic
* Use in people with hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure
|-
|'''[[Recreational drug use|Non-medical]] use/abuse:'''<br/>
*Used as a deliriant/hallucinogen
|-
|'''[[Adverse drug reaction|Side effects]]:'''
<div style="background: #ffcc99">
'''''{{red|Severe:}}'''''
* [[Myocardial infarction]] (Heart Attack), serious [[cardiac arrhythmia|ventricular dysrhythmias]], [[coma]] and [[death]]
</div>


'''''Atypical [[sensation]]s:'''''
*Feelings of heaviness, hearing disturbance


'''''[[Cardiovascular]]:'''''
*Hypertension in sensitive individuals


'''''[[Ear]], [[nose]], and [[throat]]:'''''
<!--Drug Interactions-->
*Dryness of the nose and throat, heartburn
|drugInteractions=* Drug
:* Description


'''''[[Endocrinal]]:'''''
<!--Use in Specific Populations-->
*Increased or decreased appetite
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


'''''[[Eye]]:'''''
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
*Dryness of the eyes, redness of the eyes, yellowing of the eyes
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.


'''''[[Gastrointestinal]]:'''''
<!--Administration and Monitoring-->
*Constipation, nausea
|administration=* Oral


'''''[[Hematological]]:'''''
* Intravenous
*Hepatotoxicity in extremely large dosages
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


'''''[[Muscle|Musculo]][[skeletal]]:'''''
* Description
*Incoordination, slow muscle response, [[fasciculations]] (twitching), restlessness, extrapyramidal side-effects, restless-leg syndrome


'''''[[Neurological]]:'''''
<!--IV Compatibility-->
*Confusion, clouded thinking, drowsiness, hallucinations, delirium, euphoria, short-term memory loss
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.


'''''[[Psychological]]:'''''
<!--Overdosage-->
*Agitation, anxiety, emotional lability, depression, excitability (especially in children), paranoia
|overdose====Acute Overdose===


'''''[[Respiration (physiology)|Respiratory]]:'''''
====Signs and Symptoms====
*Decreased respiration


'''''[[Skin]]:'''''
* Description
*[[Photosensitivity]], flushing


'''''[[Urogenital]] and [[reproductive]]:'''''
====Management====
*Urinary retention, sexual dysfunction, vaginal dryness, decreased libido


'''''Miscellaneous:'''''
* Description
*?
|}
{{SI}}
{{CMG}}


==Overview==
===Chronic Overdose===
'''Diphenhydramine hydrochloride''' (trade name '''[[Benadryl]]''', as produced by [[J&J]], or '''Dimedrol''' outside the U.S. & Canada. '''[[Nytol]]''' as a sleeping pill) is an [[Over-the-counter drug|over-the-counter]] (OTC) [[antihistamine]], [[sedative]] and [[hypnotic]].  It may also be used for the treatment of [[extrapyramidal]] side effects of [[typical antipsychotic]]s. It is a member of the [[ethanolamine]] class of [[antihistaminergic]] agents.


Diphenhydramine was the first known antihistamine, invented in 1943 by Dr. [[George Rieveschl]].
There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.


The brand Benadryl is currently [[trademark]]ed in the [[United States]] by [[Pfizer]], however many drug store chains and retail outlets manufacture less-costly [[Generic drug|generic versions]] under their own store brands.
<!--Pharmacology-->


== Pharmacological action ==
<!--Drug box 2-->
|drugBox=<!--Mechanism of Action-->
|mechAction=*


Diphenhydramine works by blocking the effect of histamine at [[H1 receptor|H1]] [[transmembrane receptor|receptor]] sites. This results in effects such as the reduction of [[smooth muscle]] contraction, making diphenhydramine a popular choice for treatment of the symptoms of [[Hay fever|allergic rhinitis]], [[hives]], [[motion sickness]], and insect bites and stings.
<!--Structure-->
|structure=*


In the 1960s it was found that diphenhydramine inhibits [[reuptake]] of the [[neurotransmitter]] [[serotonin]]. This discovery led to a search for viable [[antidepressant]]s with similar structures and fewer side effects, culminating in the invention of [[fluoxetine]] (Prozac), a [[selective serotonin reuptake inhibitor]] (SSRI). A similar search had previously led to the synthesis of the first SSRI [[zimelidine]] from [[chlorpheniramine]], also an antihistamine.
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]


== Common use and dosage ==
<!--Pharmacodynamics-->
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.


Diphenhydramine is a [[Antihistamine#First-generation H1-receptor antagonists|first-generation antihistamine]] drug.  Despite being one of the oldest antihistamines on the market, it is largely the most effective antihistamine available either by prescription or over-the-counter, and has been shown to exceed the effectiveness of even the latest prescription drugs.<ref>{{cite journal | author = Raphael GD, Angello JT, Wu MM, Druce HM | title = Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. | journal = Ann Allergy Asthma Immunol | volume = 96 | issue = 4 | pages = 606-614 | year = 2006 | id = PMID 16680933}}</ref> Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of the often dangerous effects of a massive histamine release.  However, it is not always the drug of choice for treating allergies.
<!--Pharmacokinetics-->
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.


It is known that diphenhydramine contains [[sedative]] properties. Many new antihistamines have been introduced without the side effect of sedation. The drug is also used as a [[sleep aid]] and is an ingredient in many sleep aids, such as [[Unisom]] gelcaps (however, the tablet form of Unisom contains [[Doxylamine]], a different active ingredient<ref>{{cite web|url=http://www.chattem.com/qna/unisomFAQ.asp#FAQ1162|title=Chattem: Unisom}}</ref>), and most notably [[Tylenol PM]] where it is combined with [[Acetaminophen]] ([[Paracetamol]]), and Nytol and Sominex which have diphenhydramine as the only active ingredient. Several generic and store brands of antihistamines and sleep aids also contain solely diphenhydramine.
<!--Nonclinical Toxicology-->
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.


Diphenhydramine is widely used in [[Over-the-counter drug|nonprescription]] sleep aids with a maximum recommended dose of 50mg (as the [[hydrochloride]] salt) being mandated by the FDA. In the [[United Kingdom]], [[Australia]], [[New Zealand]], [[South Africa]], and other countries, a 50 to 100mg recommended dose is permitted.
<!--Clinical Studies-->
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.


There are also topical formulations of diphenhydramine available, including creams, lotions, gels, and sprays.  They are used to relieve itching, and have the advantage of causing much less systemic effect (i.e. drowsiness) than oral forms.
<!--How Supplied-->
|howSupplied=*


==Side effects==
<!--Patient Counseling Information-->
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.


Like many other first generation antihistamines, diphenhydramine is a potent [[anticholinergic]] agent.  This leads to profound drowsiness as a very common side-effect, along with the possibilities of motor impairment ([[ataxia]]), dry mouth and throat, flushed skin, rapid or irregular heartbeat ([[tachycardia]]), blurred vision at nearpoint due to lack of accommodation ([[cycloplegia]]), abnormal sensitivity to bright light ([[photophobia]]), pupil dilatation ([[mydriasis]]), urinary retention ([[ischuria]]), constipation, difficulty concentrating, short-term memory loss, visual disturbances, hallucinations, confusion, erectile dysfunction, and delirium. Some side effects such as twitching may be delayed until the drowsiness begins to cease and the person is in more of an awakening mode. Diphenhydramine also has [[local anesthetic]] properties, and has been used for patients allergic to common [[local anesthetics]] like [[lidocaine]].<ref>http://www.postgradmed.com/issues/1999/08_99/smith.htm</ref> Severe, prolonged twitching and muscle spasm have also been experienced.
<!--Precautions with Alcohol-->
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.


The most common cardiac dysrhythmias associated with diphenhydramine overdose are sinus bradycardia, elongated S-T segment interval, and premature ventricular contraction.
<!--Brand Names-->
|brandNames=* ®<ref>{{Cite web | title =  | url =  }}</ref>


Diphenhydramine is very similar in its effects to [[dimenhydrinate]] (Dramamine<sup>®</sup>), its [[8-chlorotheophylline]] salt, although the latter is approximately 60% the potency in terms of required dosage and is slightly less sedating.   
<!--Look-Alike Drug Names-->
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher = | date =  }}</ref>


Some patients have an allergic reaction to diphenhydramine in the form of hives.
<!--Drug Shortage Status-->
|drugShortage=
}}
{{PillImage
|fileName=No image.jpg
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
<!--Pill Image-->


==Recreational use==
Those who use diphenhydramine [[recreational drug use|recreationally]] take a higher dose than recommended (usually between 225mg and 450mg)<ref>http://www.erowid.org/pharms/diphenhydramine/diphenhydramine_dose.shtml</ref> for its [[deliriant]] effects. Diphenhydramine is also a component of the recreational form of [[heroin]] known as "[[cheese (recreational drug)|cheese]]" or "chiva". The mental effects are described by many as "dreaming while awake" involving visual and auditory hallucinations which, unlike those experienced with most [[psychedelic drug]]s, often cannot be readily distinguished from reality.  Diphenhydramine generally has a low abuse profile due to the frequently unpleasant nature of the hallucinations.  People who consume a high recreational dose can possibly find themselves in a hallucination which places them in a familiar situation with people and friends and rooms they know, while in reality being in a totally different setting. Inexperienced users of hallucinogens are liable to [[panic]]. Many users report a side effect profile consistent with [[tropane]] [[alkaloid|glycoalkaloidal]] poisoning. 
This is due to [[receptor antagonist|antagonism]] of [[muscarinic]] [[acetylcholine]] receptors in both the [[central nervous system|central]] and [[autonomic nervous system]] which inhibits various [[signal transduction]] pathways. In the [[Central Nervous System|CNS]], diphenhydramine readily crosses the [[blood-brain barrier]], exerting effects within the  [[visual cortex|visual]] and [[primary auditory cortex|auditory cortex]]. 


Other [[Central Nervous System|CNS]] effects occur within the [[limbic system]] and [[hippocampus]], causing [[confusion]] and temporary [[amnesia]].  Toxicology also manifests in the [[autonomic nervous system]], primarily at the [[neuromuscular junction]], resulting in [[ataxia]] and [[extrapyramidal]] side-effects, and at [[sympathetic nervous system|sympathetic]] post-[[ganglion]]ic junctions, causing [[urinary retention]], pupil dilation, [[tachycardia]], irregular [[urination]], and dry skin and [[mucous membranes]].  Considerable overdosage can lead to [[myocardial infarction]] (heart attack), serious [[cardiac arrhythmia|ventricular dysrhythmias]], [[coma]] and [[death]].  Such a side-effect profile is thought to give [[ethanolamine]]-class antihistamines a relatively low abuse liability. The specific antidote for diphenhydramine poisoning is [[physostigmine]], usually given by IV in hospital.


==See also==
<!--Label Display Image-->
*[[Akathisia]]
*[[Acrivastine]] (UK Benadryl Benadryl Allergy Relief)
*[[Cetirizine]] (UK Benadryl Once-A-Day)


==External links==
*[http://media.pfizer.com/files/products/uspi_benadryl.pdf Prescription Information] ([[PDF]])
*[http://www.umm.edu/altmed/drugs/diphenhydramine-043500.htm DiphenhydrAMINE] University of Maryland Medical Center - Includes comprehensive dosage recommendations


==References==
===Notes===
<references/>
===Sources===
* Bruce G. Charlton, ''[http://www.hedweb.com/bgcharlton/sdtm.html Self-management of psychiatric symptoms using over-the-counter (OTC) psychopharmacology: the S-DTM therapeutic model - self-diagnosis, self-treatment, self-monitoring]''.  ''Medical Hypotheses'' 2005; 65: 823-828.
* J.A. Lieberman, ''History of the use of antidepressants in primary care''.  Primary Care Companion, [[Journal of Clinical Psychiatry]] [[2003]]; 5 (supplement 7).


{{Antihistamines}}
{{Antipruritics}}
{{Deliriants}}


[[de:Diphenhydramin]]
[[ja:ドリエル]]
[[ru:Димедрол]]
[[th:ไดเฟนไฮดรามีน]]


[[Category:Drugs]]
<!--Category-->
[[Category:Antiemetics]]
[[Category:Deliriants]]
[[Category:H1 receptor antagonists]]
[[Category:Muscarinic antagonists]]
[[Category:Sedatives]]
[[Category:Hypnotics]]
[[Category:Tardive dyskinesia]]
[[Category:Drugs]]


[[pl:Difenhydramina]]
[[Category:Drug]]
{{jb1}}
{{WH}}
{{WS}}

Revision as of 04:49, 12 December 2014

Diphenhydramine
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Diphenhydramine is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Diphenhydramine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Diphenhydramine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Diphenhydramine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Diphenhydramine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Diphenhydramine in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Diphenhydramine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Diphenhydramine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Diphenhydramine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Diphenhydramine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Diphenhydramine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Diphenhydramine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Diphenhydramine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Diphenhydramine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Diphenhydramine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Diphenhydramine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Diphenhydramine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Diphenhydramine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Diphenhydramine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Diphenhydramine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Diphenhydramine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Diphenhydramine in the drug label.

Pharmacology

There is limited information regarding Diphenhydramine Pharmacology in the drug label.

Mechanism of Action

Structure

File:Diphenhydramine01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Diphenhydramine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Diphenhydramine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Diphenhydramine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Diphenhydramine in the drug label.

How Supplied

Storage

There is limited information regarding Diphenhydramine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Diphenhydramine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Diphenhydramine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Diphenhydramine in the drug label.

Precautions with Alcohol

  • Alcohol-Diphenhydramine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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