Differentiating Scleroderma from other diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]

Overview

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating X from other Diseases

• [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
• [Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

• As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Preferred Table

Diseases		Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
		Symptoms			Physical examination
								Lab Findings			Imaging			Histopathology
		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Systemic diseases	Scleroderma
	Scleromyxedema
	Amyloidosis
	Eosinophilic fasciitis
	Chronic graft-versus-host disease
	Drug induced scleroderma
Scleroderma overlap syndromes	Systemic lupus erythematosus
	Dermatomyositis
	Rheumatoid arthritis
Endocrine disorders	Diabetes mellitus (diabetic cheiroarthropathy)
	Myxedema due to hypothyroidism
	POEMS syndrome
Renal diseases	Nephrogenic systemic fibrosis