Diethylcarbamazine: Difference between revisions

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{{drugbox
__NOTOC__
| IUPAC_name = 4-methyl-N,N-bis (4-methylpiperazin-2-yl)- piperazine-1-carboxamide
{{Diethylcarbamazine}}
| image =
{{CMG}}
| CAS_number = 90-89-1
| ATC_prefix = P02
| ATC_suffix = CB02
| ATC_supplemental =
| PubChem = 3052
| DrugBank = APRD00918
| C=10 | H=21 | N=3 | O=1
| molecular_weight = 199.293 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_status =
| routes_of_administration =
}}


'''Diethylcarbamazine''' (DEC) is an [[anthelmintic]] [[medication|drug]] that does not resemble other antiparasitic compounds. It is a synthetic [[organic compound]] which is highly specific for several [[parasite]]s and does not contain any [[toxic]] metallic elements.
==Overview==


==Uses==
Diethylcarbamazine (DEC) is an [[anthelmintic]] [[medication|drug]] that does not resemble other antiparasitic compounds. It is a synthetic[[organic compound]] which is highly specific for several parasites and does not contain any [[toxic]] metallic elements.
DEC is indicated for treatment of individual patients with certain [[Filariasis|filaria]]l [[disease]]s. These diseases include: [[lymphatic filariasis]] caused by [[infection]] with ''[[Wuchereria bancrofti]]'', ''[[Brugia malayi]]'', or ''[[Brugia timori]]''; tropical [[pulmonary eosinophilia]], and [[loiasis]].
 
==Category==
 
Antiparasitic
 
==US Brand Names==
 
HETRAZAN<sup>®</sup>
 
==FDA Package Insert==
 
'''  [[Diethylcarbamazine description|Description]]'''
'''| [[Diethylcarbamazine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Diethylcarbamazine microbiology|Microbiology]]'''
'''| [[Diethylcarbamazine indications and usage|Indications and Usage]]'''
'''| [[Diethylcarbamazine contraindications|Contraindications]]'''
'''| [[Diethylcarbamazine warnings and precautions|Warnings and Precautions]]'''
'''| [[Diethylcarbamazine adverse reactions|Adverse Reactions]]'''
'''| [[Diethylcarbamazine drug interactions|Drug Interactions]]'''
'''| [[Diethylcarbamazine overdosage|Overdosage]]'''
'''| [[Diethylcarbamazine clinical studies|Clinical Studies]]'''
'''| [[Diethylcarbamazine dosage and administration|Dosage and Administration]]'''
'''| [[Diethylcarbamazine how supplied|How Supplied]]'''
'''| [[Diethylcarbamazine labels and packages|Labels and Packages]]'''
 
==Mechanism of Action==


In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because the itching associated with the dead subcutaneous parasites causes intense and unbearable itching.  
DEC is an inhibitor of [[arachidonic acid]] metabolism in filaria. This makes the filaria more susceptible to immune attack.


DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog [[heartworm]] ''Dirofilaria immitis''.
==Uses==


==Mechanism==
DEC is indicated for treatment of individual patients with certain [[Filariasis|filaria]]l [[disease]]s. These diseases include: [[lymphatic filariasis]] caused by [[infection]] with ''[[Wuchereria bancrofti]]'', ''[[Brugia malayi]]'', or ''[[Brugia timori]]''; tropical [[pulmonary eosinophilia]], and [[loiasis]].
DEC is an inhibitor of [[arachidonic acid]] metabolism in filarial mf. This makes the mf more susceptible to immune attack.


==Trade names==
In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because the itching associated with the dead subcutaneous parasites causes intense and unbearable itching.
*Hetrazan
*Carbilazine
*Caricide
*Cypip
*Ethodryl
*Notézine
*Spatonin
*Filaribits
*Banocide Forte


[[Category:Antiparasitic agents]]
DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog[[heartworm]] ''Dirofilaria immitis''.
[[Category:Piperazines]]


==References==
{{Reflist|2}}


{{treatment-stub}}
[[Category:Antibiotics]]
{{Anthelmintics}}
[[Category:Wikinfect]]

Revision as of 02:02, 7 January 2014

Diethylcarbamazine
HETRAZAN® WHO Prescribing Information
Description
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Diethylcarbamazine (DEC) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a syntheticorganic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Category

Antiparasitic

US Brand Names

HETRAZAN®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

DEC is an inhibitor of arachidonic acid metabolism in filaria. This makes the filaria more susceptible to immune attack.

Uses

DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because the itching associated with the dead subcutaneous parasites causes intense and unbearable itching.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dogheartworm Dirofilaria immitis.

References

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