Diabetic retinopathy epidemiology and demographics: Difference between revisions

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Between 40 to 45 percent of Americans diagnosed with diabetes have some stage of diabetic retinopathy.  <ref name=NIHSenior>{{cite web | title =NIHSeniorHealth: Diabetic Retinopathy - Causes and Risk Factors | publisher=NIHSenior Health | work =Diabetic Retinopathy  | url=http://nihseniorhealth.gov/diabeticretinopathy/causesandriskfactors/02.html | year = 2005 }}</ref>
Between 40 to 45 percent of Americans diagnosed with diabetes have some stage of diabetic retinopathy.  <ref name=NIHSenior>{{cite web | title =NIHSeniorHealth: Diabetic Retinopathy - Causes and Risk Factors | publisher=NIHSenior Health | work =Diabetic Retinopathy  | url=http://nihseniorhealth.gov/diabeticretinopathy/causesandriskfactors/02.html | year = 2005 }}</ref>
==Epidemiology and Demographics==
==Epidemiology and Demographics==
After 20 years of diabetes, nearly all patients with type 1 diabetes and >60% of patients with type 2 diabetes have some degree of retinopathy. In the Wisconsin Epidemiologic Study of Diabetic Retinopathy, 3.6% of patients with type 1 diabetes and 1.6% of type 2 diabetes were legally blind. In the type 1 diabetes, 86% of blindness was attributable to diabetic retinopathy. The cumulative incidence of any retinopathy in type 1 diabetes was 97%.  In the type 2 diabetic patients, where other eye diseases were common, one-third of the cases of legal blindness were due to diabetic retinopathy. <ref name="pmid18025409">{{cite journal| author=Hirai FE, Moss SE, Klein BE, Klein R| title=Relationship of glycemic control, exogenous insulin, and C-peptide levels to ischemic heart disease mortality over a 16-year period in people with older-onset diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). | journal=Diabetes Care | year= 2008 | volume= 31 | issue= 3 | pages= 493-7 | pmid=18025409 | doi=10.2337/dc07-1161 | pmc=PMC2773445 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18025409  }} </ref>
The prevalence of all types of diabetic retinopathy in the diabetic population increases with the
=== Genetics ===
duration of the disease and patient age. Diabetic retinopathy is rare in children younger than 10 years
There are evidence that not every diabetic patients has the same risk of diabetic retinopathy. Studies have shown that polymorphisms of [[Tumor Necrosis Factor Alpha]] play an important role in the risk of patients with diabetic retinopathy.<ref name="pmid22105495">{{cite journal| author=Paine SK, Sen A, Choudhuri S, Mondal LK, Chowdhury IH, Basu A et al.| title=Association of tumor necrosis factor α, interleukin 6, and interleukin 10 promoter polymorphism with proliferative diabetic retinopathy in type 2 diabetic subjects. | journal=Retina | year= 2012 | volume= 32 | issue= 6 | pages= 1197-203 | pmid=22105495 | doi=10.1097/IAE.0b013e31822f55f3 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22105495  }} </ref>
of age; however, the risk of developing diabetic retinopathy increases after puberty.
The Wisconsin Epidemiologic Study of Diabetic Retinopathy
The Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) is an ongoing epidemiologic
study of the progression of diabetic retinopathy; progression is monitored by stereoscopic fundus
photographs taken in 7 standard fields along with measurements of glycosylated hemoglobin levels
and visual acuity. An important epidemiologic finding of the WESDR was the direct association of an
increased prevalence of diabetic retinopathy, in both type 1 and type 2 forms, with the duration of
diabetes mellitus. After 20 years of diabetes mellitus, nearly 99% of patients with type 1 and 60%
with type 2 disease demonstrated some degree of diabetic retinopathy. Proliferative diabetic
retinopathy was found in 50% of type 1 patients who had 20 years’ duration of disease and in 25% of
type 2 patients who had 25 years’ duration of disease. Furthermore, 3.6% of younger-onset patients
(aged <30 years at diagnosis, an operational definition of type 1 diabetes mellitus) and 1.6% of
older-onset patients (aged ≥30 years at diagnosis, an operational definition of type 2 diabetes
mellitus) were found to have a visual acuity of 20/200 or worse. Such vision loss was attributable to
diabetic retinopathy in 86% of the younger-onset patients and in 33% of the older-onset group.
WESDR epidemiologic data were based largely on white populations of northern European
descent and therefore are not entirely applicable to other racial groups. According to the National
Health and Nutrition Examination Survey (NHANES) III, in 2011, the age-adjusted percentage of
adults with diagnosed diabetes mellitus who reported visual impairment was 20.7% for blacks,
17.1% for whites, and 15.6% for Hispanics.


== References ==
== References ==

Revision as of 19:41, 4 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Afsaneh Morteza, MD-MPH [2]

Overview

Between 40 to 45 percent of Americans diagnosed with diabetes have some stage of diabetic retinopathy. [1]

Epidemiology and Demographics

The prevalence of all types of diabetic retinopathy in the diabetic population increases with the duration of the disease and patient age. Diabetic retinopathy is rare in children younger than 10 years of age; however, the risk of developing diabetic retinopathy increases after puberty. The Wisconsin Epidemiologic Study of Diabetic Retinopathy The Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) is an ongoing epidemiologic study of the progression of diabetic retinopathy; progression is monitored by stereoscopic fundus photographs taken in 7 standard fields along with measurements of glycosylated hemoglobin levels and visual acuity. An important epidemiologic finding of the WESDR was the direct association of an increased prevalence of diabetic retinopathy, in both type 1 and type 2 forms, with the duration of diabetes mellitus. After 20 years of diabetes mellitus, nearly 99% of patients with type 1 and 60% with type 2 disease demonstrated some degree of diabetic retinopathy. Proliferative diabetic retinopathy was found in 50% of type 1 patients who had 20 years’ duration of disease and in 25% of type 2 patients who had 25 years’ duration of disease. Furthermore, 3.6% of younger-onset patients (aged <30 years at diagnosis, an operational definition of type 1 diabetes mellitus) and 1.6% of older-onset patients (aged ≥30 years at diagnosis, an operational definition of type 2 diabetes mellitus) were found to have a visual acuity of 20/200 or worse. Such vision loss was attributable to diabetic retinopathy in 86% of the younger-onset patients and in 33% of the older-onset group. WESDR epidemiologic data were based largely on white populations of northern European descent and therefore are not entirely applicable to other racial groups. According to the National Health and Nutrition Examination Survey (NHANES) III, in 2011, the age-adjusted percentage of adults with diagnosed diabetes mellitus who reported visual impairment was 20.7% for blacks, 17.1% for whites, and 15.6% for Hispanics.

References

  1. "NIHSeniorHealth: Diabetic Retinopathy - Causes and Risk Factors". Diabetic Retinopathy. NIHSenior Health. 2005.


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