DYNC1I1: Difference between revisions

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{{Infobox_gene}}
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'''Cytoplasmic dynein 1 intermediate chain 1''' is a [[protein]] that in humans is encoded by the ''DYNC1I1'' [[gene]].<ref name="pmid10049579">{{cite journal | vauthors = Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC | title = Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human | journal = Genomics | volume = 55 | issue = 3 | pages = 257–67 |date=May 1999 | pmid = 10049579 | pmc =  | doi = 10.1006/geno.1998.5665 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1780| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Dynein, cytoplasmic 1, intermediate chain 1
| HGNCid = 2963
| Symbol = DYNC1I1
| AltSymbols =; DNCI1; DNCIC1
| OMIM = 603772
| ECnumber =
| Homologene = 68398
| MGIid = 107743
  | GeneAtlas_image1 = PBB_GE_DYNC1I1_205348_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005868 |text = cytoplasmic dynein complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1780
    | Hs_Ensembl = ENSG00000158560
    | Hs_RefseqProtein = NP_004402
    | Hs_RefseqmRNA = NM_004411
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 95239802
    | Hs_GenLoc_end = 95565671
    | Hs_Uniprot = O14576
    | Mm_EntrezGene = 13426
    | Mm_Ensembl = ENSMUSG00000029757
    | Mm_RefseqmRNA = NM_010063
    | Mm_RefseqProtein = NP_034193
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 5675808
    | Mm_GenLoc_end = 5978039
    | Mm_Uniprot = Q3TYJ3
  }}
}}
'''Dynein, cytoplasmic 1, intermediate chain 1''', also known as '''DYNC1I1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1780| accessdate = }}</ref>


In melanocytic cells DYNC1I1 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x |display-authors=etal}}</ref>
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==Interactions==
DYNC1I1 has been shown to [[Protein-protein interaction|interact]] with [[DYNLL1]].<ref name=pmid12475239>{{cite journal |doi=10.1021/bi026417u |last=Diefenbach |first=Russell J |author2=Diefenbach Eve |author3=Douglas Mark W |author4=Cunningham Anthony L  |date=Dec 2002 |title=The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 |journal=Biochemistry |volume=41 |issue=50 |pages=14906–15 |publisher= |location = United States| issn = 0006-2960| pmid = 12475239 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=King SM, Dillman JF, Benashski SE, ''et al.'' |title=The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32281-7 |year= 1997 |pmid= 8943288 |doi= }}
*{{cite journal  | vauthors=King SM, Dillman JF, Benashski SE |title=The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32281–7 |year= 1997 |pmid= 8943288 |doi=10.1074/jbc.271.50.32281  |display-authors=etal}}
*{{cite journal  | author=Crackower MA, Sinasac DS, Xia J, ''et al.'' |title=Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. |journal=Genomics |volume=55 |issue= 3 |pages= 257-67 |year= 1999 |pmid= 10049579 |doi= 10.1006/geno.1998.5665 }}
*{{cite journal  | vauthors=Lo KW, Naisbitt S, Fan JS |title=The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14059–66 |year= 2001 |pmid= 11148209 |doi= 10.1074/jbc.M010320200 |display-authors=etal}}
*{{cite journal  | author=Lo KW, Naisbitt S, Fan JS, ''et al.'' |title=The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14059-66 |year= 2001 |pmid= 11148209 |doi= 10.1074/jbc.M010320200 }}
*{{cite journal  | vauthors=Horikawa I, Parker ES, Solomon GG, Barrett JC |title=Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells. |journal=J. Cell. Biochem. |volume=82 |issue= 3 |pages= 415–21 |year= 2001 |pmid= 11500918 |doi=10.1002/jcb.1169 }}
*{{cite journal  | author=Horikawa I, Parker ES, Solomon GG, Barrett JC |title=Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells. |journal=J. Cell. Biochem. |volume=82 |issue= 3 |pages= 415-21 |year= 2001 |pmid= 11500918 |doi=  }}
*{{cite journal  | vauthors=Karki S, Ligon LA, DeSantis J |title=PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact. |journal=Mol. Biol. Cell |volume=13 |issue= 5 |pages= 1722–34 |year= 2002 |pmid= 12006665 |doi= 10.1091/mbc.02-02-0011 | pmc=111139 |display-authors=etal}}
*{{cite journal  | author=Karki S, Ligon LA, DeSantis J, ''et al.'' |title=PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact. |journal=Mol. Biol. Cell |volume=13 |issue= 5 |pages= 1722-34 |year= 2002 |pmid= 12006665 |doi= 10.1091/mbc.02-02-0011 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |display-authors=etal}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ligon LA, Tokito M, Finklestein JM |title=A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19201–8 |year= 2004 |pmid= 14985359 |doi= 10.1074/jbc.M313472200 |display-authors=etal}}
*{{cite journal  | author=Ligon LA, Tokito M, Finklestein JM, ''et al.'' |title=A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19201-8 |year= 2004 |pmid= 14985359 |doi= 10.1074/jbc.M313472200 }}
*{{cite journal  | vauthors=Villacé P, Marión RM, Ortín J |title=The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. |journal=Nucleic Acids Res. |volume=32 |issue= 8 |pages= 2411–20 |year= 2004 |pmid= 15121898 |doi= 10.1093/nar/gkh552 | pmc=419443 }}
*{{cite journal  | author=Villacé P, Marión RM, Ortín J |title=The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. |journal=Nucleic Acids Res. |volume=32 |issue= 8 |pages= 2411-20 |year= 2004 |pmid= 15121898 |doi= 10.1093/nar/gkh552 }}
*{{cite journal  | vauthors=Chuang JZ, Yeh TY, Bollati F |title=The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. |journal=Dev. Cell |volume=9 |issue= 1 |pages= 75–86 |year= 2005 |pmid= 15992542 |doi= 10.1016/j.devcel.2005.04.003 |display-authors=etal}}
*{{cite journal  | author=Chuang JZ, Yeh TY, Bollati F, ''et al.'' |title=The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. |journal=Dev. Cell |volume=9 |issue= 1 |pages= 75-86 |year= 2005 |pmid= 15992542 |doi= 10.1016/j.devcel.2005.04.003 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Pfister KK, Fisher EM, Gibbons IR, ''et al.'' |title=Cytoplasmic dynein nomenclature. |journal=J. Cell Biol. |volume=171 |issue= 3 |pages= 411-3 |year= 2006 |pmid= 16260502 |doi= 10.1083/jcb.200508078 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:47, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.[1][2][3]

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.[4]

Interactions

DYNC1I1 has been shown to interact with DYNLL1.[5]

References

  1. ↑ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
  2. ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  3. ↑ "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1".
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  5. ↑ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. United States. 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239.

Further reading



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