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{{ | '''Segment polarity protein dishevelled homolog DVL-2''' is a [[protein]] that in humans is encoded by the ''DVL2'' [[gene]].<ref name="pmid8662242">{{cite journal | vauthors = Greco TL, Sussman DJ, Camper SA | title = Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11 | journal = Mamm Genome | volume = 7 | issue = 6 | pages = 475–6 | date=January 1997| pmid = 8662242 | pmc = | doi =10.1007/s003359900144 }}</ref><ref name="entrez"/> | ||
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| summary_text = This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.<ref name="entrez">{{cite web | title = Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)| url = | | summary_text = This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.<ref name="entrez">{{cite web | title = Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1856| accessdate = }}</ref> | ||
}} | }} | ||
==Interactions== | |||
DVL2 has been shown to [[Protein-protein interaction|interact]] with [[Zinc finger protein 165]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005|title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[DAB2]]<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H |date=June 2003|title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> and [[Arrestin beta 1]].<ref name=pmid11742073>{{cite journal |last=Chen |first=W |author2=Hu L A |author3=Semenov M V |author4=Yanagawa S |author5=Kikuchi A |author6=Lefkowitz R J |author7=Miller W E |date=December 2001|title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=26 |pages=14889–94 |publisher= |location = United States| issn = 0027-8424| pmid = 11742073 |doi = 10.1073/pnas.211572798 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=64954 }}</ref> | |||
==See also== | |||
* [[Dishevelled]] | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Pizzuti A, Amati F, Calabrese G |title=cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 953–8 |year= 1997 |pmid= 8817329 |doi=10.1093/hmg/5.7.953 |display-authors=etal}} | ||
*{{cite journal | vauthors=Klingensmith J, Yang Y, Axelrod JD |title=Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2 |journal=Mech. Dev. |volume=58 |issue= 1–2 |pages= 15–26 |year= 1997 |pmid= 8887313 |doi=10.1016/S0925-4773(96)00549-7 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Semënov MV, Snyder M |title=Human dishevelled genes constitute a DHR-containing multigene family |journal=Genomics |volume=42 |issue= 2 |pages= 302–10 |year= 1997 |pmid= 9192851 |doi= 10.1006/geno.1997.4713 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strovel ET, Wu D, Sussman DJ |title=Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2399–403 |year= 2000 |pmid= 10644691 |doi=10.1074/jbc.275.4.2399 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Zhang Y, Neo SY, Han J, Lin SC |title=Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 25008–14 |year= 2000 |pmid= 10829020 |doi= 10.1074/jbc.M002491200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Chen W, Hu LA, Semenov MV |title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 14889–94 |year= 2002 |pmid= 11742073 |doi= 10.1073/pnas.211572798 | pmc=64954 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Habas R, Kato Y, He X |title=Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 |journal=Cell |volume=107 |issue= 7 |pages= 843–54 |year= 2002 |pmid= 11779461 |doi=10.1016/S0092-8674(01)00614-6 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Habas R, Dawid IB, He X |title=Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation |journal=Genes Dev. |volume=17 |issue= 2 |pages= 295–309 |year= 2003 |pmid= 12533515 |doi= 10.1101/gad.1022203 | pmc=195976 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Chen W, ten Berge D, Brown J |title=Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 |journal=Science |volume=301 |issue= 5638 |pages= 1391–4 |year= 2003 |pmid= 12958364 |doi= 10.1126/science.1082808 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Wong CK, Luo W, Deng Y |title=The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39366–73 |year= 2004 |pmid= 15262978 |doi= 10.1074/jbc.M404598200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Zhang L, Gao X, Wen J |title=Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation |journal=J. Biol. Chem. |volume=281 |issue= 13 |pages= 8607–12 |year= 2006 |pmid= 16446366 |doi= 10.1074/jbc.M600274200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=1856}} | |||
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{{ | {{gene-17-stub}} | ||
Revision as of 18:46, 30 August 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
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Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[1][2]
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[2]
Interactions
DVL2 has been shown to interact with Zinc finger protein 165,[3] DAB2[4] and Arrestin beta 1.[5]
See also
References
- ↑ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242.
- ↑ 2.0 2.1 "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
- ↑ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
- ↑ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. United States. 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073.
Further reading
- Pizzuti A, Amati F, Calabrese G, et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum. Mol. Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
- Klingensmith J, Yang Y, Axelrod JD, et al. (1997). "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2". Mech. Dev. 58 (1–2): 15–26. doi:10.1016/S0925-4773(96)00549-7. PMID 8887313.
- Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics. 42 (2): 302–10. doi:10.1006/geno.1997.4713. PMID 9192851.
- Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691.
- Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–7. doi:10.1074/jbc.M909107199. PMID 10806215.
- Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 275 (32): 25008–14. doi:10.1074/jbc.M002491200. PMID 10829020.
- Chen W, Hu LA, Semenov MV, et al. (2002). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. doi:10.1073/pnas.211572798. PMC 64954. PMID 11742073.
- Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell. 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Habas R, Dawid IB, He X (2003). "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation". Genes Dev. 17 (2): 295–309. doi:10.1101/gad.1022203. PMC 195976. PMID 12533515.
- Chen W, ten Berge D, Brown J, et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science. 301 (5638): 1391–4. doi:10.1126/science.1082808. PMID 12958364.
- Wong CK, Luo W, Deng Y, et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". J. Biol. Chem. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978.
- Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–13. doi:10.1074/jbc.M408675200. PMID 15456783.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Zhang L, Gao X, Wen J, et al. (2006). "Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation". J. Biol. Chem. 281 (13): 8607–12. doi:10.1074/jbc.M600274200. PMID 16446366.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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