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{{Infobox_gene}}
{{PBB_Controls
'''Segment polarity protein dishevelled homolog DVL-1''' is a [[protein]] that in humans is encoded by the ''DVL1'' [[gene]].<ref name="pmid8817329">{{cite journal | vauthors = Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calzà L, Palka G, Scarlato G, Novelli G, Dallapiccola B | title = cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene | journal = Hum Mol Genet | volume = 5 | issue = 7 | pages = 953–8 | date = Jan 1997 | pmid = 8817329 | pmc = | doi = 10.1093/hmg/5.7.953 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DVL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fsh.
| PDB = {{PDB2|1fsh}}, {{PDB2|1mc7}}
| Name = Dishevelled, dsh homolog 1 (Drosophila)
| HGNCid = 3084
| Symbol = DVL1
| AltSymbols =; DVL; MGC54245
| OMIM = 601365
| ECnumber = 
| Homologene = 20926
| MGIid = 94941
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1855
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004412
    | Hs_RefseqmRNA = NM_004421
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 13542
    | Mm_Ensembl = ENSMUSG00000029071
    | Mm_RefseqmRNA = NM_010091
    | Mm_RefseqProtein = NP_034221
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 154691212
    | Mm_GenLoc_end = 154703103
    | Mm_Uniprot = Q3TRW4
  }}
}}
'''Dishevelled, dsh homolog 1 (Drosophila)''', also known as '''DVL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DVL1, the human homolog of the Drosophila [[dishevelled]] gene (dsh) encodes a cytoplasmic [[phosphoprotein]] that regulates [[cell proliferation]], acting as a transducer molecule for developmental processes, including segmentation and [[neuroblast]] specification. DVL1 is a candidate gene for processes involved in cell transformations involved in [[neuroblastoma]]. The [[Schwartz-Jampel syndrome]] and [[Charcot-Marie-Tooth disease]] type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DVL1 has been shown to [[Protein-protein interaction|interact]] with:
* [[AXIN1]],<ref name = pmid10428961>{{cite journal | vauthors = Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D | title = Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4233–40 | date = Aug 1999 | pmid = 10428961 | pmc = 1171499 | doi = 10.1093/emboj/18.15.4233 }}</ref><ref name = pmid18632848>{{cite journal | vauthors = Kim MJ, Chia IV, Costantini F | title = SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability | journal = FASEB J. | volume = 22 | issue = 11 | pages = 3785–94 | date = Nov 2008 | pmid = 18632848 | pmc = 2574027 | doi = 10.1096/fj.08-113910 }}</ref>
* [[DVL3]],<ref name = pmid10330181>{{cite journal | vauthors = Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A | title = DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4414–22 | date = Jun 1999 | pmid = 10330181 | pmc = 104400 | doi =  10.1128/mcb.19.6.4414}}</ref>
* [[EPS8]],<ref name = pmid10581192>{{cite journal | vauthors = Inobe M, ((Katsube Ki)), Miyagoe Y, ((Nabeshima Yi)), Takeda S | title = Identification of EPS8 as a Dvl1-associated molecule | journal = Biochem. Biophys. Res. Commun. | volume = 266 | issue = 1 | pages = 216–21 | date = Dec 1999 | pmid = 10581192 | doi = 10.1006/bbrc.1999.1782 }}</ref>  and
* [[Mothers against decapentaplegic homolog 3]].<ref name = pmid12650946>{{cite journal | vauthors = Warner DR, Pisano MM, Roberts EA, Greene RM | title = Identification of three novel Smad binding proteins involved in cell polarity | journal = FEBS Lett. | volume = 539 | issue = 1-3 | pages = 167–73 | date = Mar 2003 | pmid = 12650946 | doi =  10.1016/s0014-5793(03)00155-8}}</ref>
 
== See also ==
* [[Dishevelled]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wharton KA | title = Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction | journal = Dev. Biol. | volume = 253 | issue = 1 | pages = 1–17 | year = 2003 | pmid = 12490194 | doi = 10.1006/dbio.2002.0869 }}
| citations =
* {{cite journal | vauthors = Klingensmith J, Nusse R, Perrimon N | title = The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal | journal = Genes Dev. | volume = 8 | issue = 1 | pages = 118–30 | year = 1994 | pmid = 8288125 | doi = 10.1101/gad.8.1.118 }}
*{{cite journal | author=Wharton KA |title=Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. |journal=Dev. Biol. |volume=253 |issue= 1 |pages= 1-17 |year= 2003 |pmid= 12490194 |doi= }}
* {{cite journal | vauthors = Pizzuti A, Novelli G, Mari A, Ratti A, Colosimo A, Amati F, Penso D, Sangiuolo F, Calabrese G, Palka G, Silani V, Gennarelli M, Mingarelli R, Scarlato G, Scambler P, Dallapiccola B | title = Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome | journal = Am. J. Hum. Genet. | volume = 58 | issue = 4 | pages = 722–9 | year = 1996 | pmid = 8644734 | pmc = 1914677 | doi =  }}
*{{cite journal | author=Klingensmith J, Nusse R, Perrimon N |title=The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. |journal=Genes Dev. |volume=8 |issue= 1 |pages= 118-30 |year= 1994 |pmid= 8288125 |doi= }}
* {{cite journal | vauthors = Steitz SA, Tsang M, Sussman DJ | title = Wnt-mediated relocalization of dishevelled proteins | journal = In Vitro Cell. Dev. Biol. Anim. | volume = 32 | issue = 7 | pages = 441–5 | year = 1997 | pmid = 8856345 | doi = 10.1007/BF02723007 }}
*{{cite journal | author=Pizzuti A, Novelli G, Mari A, ''et al.'' |title=Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. |journal=Am. J. Hum. Genet. |volume=58 |issue= 4 |pages= 722-9 |year= 1996 |pmid= 8644734 |doi=  }}
* {{cite journal | vauthors = Semënov MV, Snyder M | title = Human dishevelled genes constitute a DHR-containing multigene family | journal = Genomics | volume = 42 | issue = 2 | pages = 302–10 | year = 1997 | pmid = 9192851 | doi = 10.1006/geno.1997.4713 }}
*{{cite journal | author=Pizzuti A, Amati F, Calabrese G, ''et al.'' |title=cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 953-8 |year= 1997 |pmid= 8817329 |doi= }}
* {{cite journal | vauthors = Bui TD, Beier DR, Jonssen M, Smith K, Dorrington SM, Kaklamanis L, Kearney L, Regan R, Sussman DJ, Harris AL | title = cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 510–6 | year = 1997 | pmid = 9344861 | doi = 10.1006/bbrc.1997.7500 }}
*{{cite journal | author=Steitz SA, Tsang M, Sussman DJ |title=Wnt-mediated relocalization of dishevelled proteins. |journal=In Vitro Cell. Dev. Biol. Anim. |volume=32 |issue= 7 |pages= 441-5 |year= 1997 |pmid= 8856345 |doi= }}
* {{cite journal | vauthors = Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A | title = Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin | journal = EMBO J. | volume = 17 | issue = 5 | pages = 1371–84 | year = 1998 | pmid = 9482734 | pmc = 1170485 | doi = 10.1093/emboj/17.5.1371 }}
*{{cite journal | author=Semënov MV, Snyder M |title=Human dishevelled genes constitute a DHR-containing multigene family. |journal=Genomics |volume=42 |issue= 2 |pages= 302-10 |year= 1997 |pmid= 9192851 |doi= 10.1006/geno.1997.4713 }}
* {{cite journal | vauthors = Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A | title = DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4414–22 | year = 1999 | pmid = 10330181 | pmc = 104400 | doi = 10.1128/mcb.19.6.4414}}
*{{cite journal | author=Bui TD, Beier DR, Jonssen M, ''et al.'' |title=cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 510-6 |year= 1997 |pmid= 9344861 |doi= 10.1006/bbrc.1997.7500 }}
* {{cite journal | vauthors = Fagotto F, ((Jho Eh)), Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F | title = Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization | journal = J. Cell Biol. | volume = 145 | issue = 4 | pages = 741–56 | year = 1999 | pmid = 10330403 | pmc = 2133179 | doi = 10.1083/jcb.145.4.741 }}
*{{cite journal | author=Ikeda S, Kishida S, Yamamoto H, ''et al.'' |title=Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1371-84 |year= 1998 |pmid= 9482734 |doi= 10.1093/emboj/17.5.1371 }}
* {{cite journal | vauthors = Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D | title = Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4233–40 | year = 1999 | pmid = 10428961 | pmc = 1171499 | doi = 10.1093/emboj/18.15.4233 }}
*{{cite journal | author=Kishida S, Yamamoto H, Hino S, ''et al.'' |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414-22 |year= 1999 |pmid= 10330181 |doi= }}
* {{cite journal | vauthors = Strovel ET, Wu D, Sussman DJ | title = Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription | journal = J. Biol. Chem. | volume = 275 | issue = 4 | pages = 2399–403 | year = 2000 | pmid = 10644691 | doi = 10.1074/jbc.275.4.2399 }}
*{{cite journal | author=Fagotto F, Jho E, Zeng L, ''et al.'' |title=Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 741-56 |year= 1999 |pmid= 10330403 |doi= }}
* {{cite journal | vauthors = Song DH, Sussman DJ, Seldin DC | title = Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23790–7 | year = 2000 | pmid = 10806215 | doi = 10.1074/jbc.M909107199 }}
*{{cite journal | author=Li L, Yuan H, Weaver CD, ''et al.'' |title=Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. |journal=EMBO J. |volume=18 |issue= 15 |pages= 4233-40 |year= 1999 |pmid= 10428961 |doi= 10.1093/emboj/18.15.4233 }}
* {{cite journal | vauthors = Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A | title = Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein | journal = Mol. Cell. Biol. | volume = 21 | issue = 1 | pages = 330–42 | year = 2001 | pmid = 11113207 | pmc = 88806 | doi = 10.1128/MCB.21.1.330-342.2001 }}
*{{cite journal | author=Inobe M, Katsube K, Miyagoe Y, ''et al.'' |title=Identification of EPS8 as a Dvl1-associated molecule. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 216-21 |year= 2000 |pmid= 10581192 |doi= 10.1006/bbrc.1999.1782 }}
* {{cite journal | vauthors = Rubinfeld B, Tice DA, Polakis P | title = Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon | journal = J. Biol. Chem. | volume = 276 | issue = 42 | pages = 39037–45 | year = 2001 | pmid = 11487578 | doi = 10.1074/jbc.M105148200 }}
*{{cite journal | author=Strovel ET, Wu D, Sussman DJ |title=Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2399-403 |year= 2000 |pmid= 10644691 |doi= }}
* {{cite journal | vauthors = Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE | title = beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 26 | pages = 14889–94 | year = 2002 | pmid = 11742073 | pmc = 64954 | doi = 10.1073/pnas.211572798 }}
*{{cite journal | author=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790-7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
* {{cite journal | vauthors = Habas R, Kato Y, He X | title = Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 | journal = Cell | volume = 107 | issue = 7 | pages = 843–54 | year = 2002 | pmid = 11779461 | doi = 10.1016/S0092-8674(01)00614-6 }}
*{{cite journal | author=Hino S, Kishida S, Michiue T, ''et al.'' |title=Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. |journal=Mol. Cell. Biol. |volume=21 |issue= 1 |pages= 330-42 |year= 2001 |pmid= 11113207 |doi= 10.1128/MCB.21.1.330-342.2001 }}
* {{cite journal | vauthors = Russ C, Lovestone S, Powell JF | title = Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease | journal = Mol. Psychiatry | volume = 7 | issue = 1 | pages = 104–9 | year = 2002 | pmid = 11803455 | doi = 10.1038/sj/mp/4000941 }}
*{{cite journal | author=Rubinfeld B, Tice DA, Polakis P |title=Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39037-45 |year= 2001 |pmid= 11487578 |doi= 10.1074/jbc.M105148200 }}
* {{cite journal | vauthors = Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM | title = Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 3 | pages = 1182–7 | year = 2002 | pmid = 11818547 | pmc = 122164 | doi = 10.1073/pnas.032468199 }}
*{{cite journal | author=Chen W, Hu LA, Semenov MV, ''et al.'' |title=beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 14889-94 |year= 2002 |pmid= 11742073 |doi= 10.1073/pnas.211572798 }}
*{{cite journal | author=Habas R, Kato Y, He X |title=Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. |journal=Cell |volume=107 |issue= 7 |pages= 843-54 |year= 2002 |pmid= 11779461 |doi=  }}
*{{cite journal  | author=Russ C, Lovestone S, Powell JF |title=Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 104-9 |year= 2002 |pmid= 11803455 |doi= 10.1038/sj/mp/4000941 }}
*{{cite journal  | author=Gao ZH, Seeling JM, Hill V, ''et al.'' |title=Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 3 |pages= 1182-7 |year= 2002 |pmid= 11818547 |doi= 10.1073/pnas.032468199 }}
}}
{{refend}}
{{refend}}
== External links ==
* [http://atlasgeneticsoncology.org/Genes/DVL1ID463ch1p36.html DVL1] on the [[Atlas of Genetics and Cytogenetics in Oncology and Haematology|Atlas of Genetics and Oncology]]
{{PDB Gallery|geneid=1855}}


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{{protein-stub}}
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Latest revision as of 18:46, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.[1][2]

Function

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for processes involved in cell transformations involved in neuroblastoma. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.[2]

Interactions

DVL1 has been shown to interact with:

See also

References

  1. ↑ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calzà L, Palka G, Scarlato G, Novelli G, Dallapiccola B (Jan 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
  2. ↑ 2.0 2.1 "Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)".
  3. ↑ Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D (Aug 1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMC 1171499. PMID 10428961.
  4. ↑ Kim MJ, Chia IV, Costantini F (Nov 2008). "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability". FASEB J. 22 (11): 3785–94. doi:10.1096/fj.08-113910. PMC 2574027. PMID 18632848.
  5. ↑ Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (Jun 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6): 4414–22. doi:10.1128/mcb.19.6.4414. PMC 104400. PMID 10330181.
  6. ↑ Inobe M, Katsube Ki, Miyagoe Y, Nabeshima Yi, Takeda S (Dec 1999). "Identification of EPS8 as a Dvl1-associated molecule". Biochem. Biophys. Res. Commun. 266 (1): 216–21. doi:10.1006/bbrc.1999.1782. PMID 10581192.
  7. ↑ Warner DR, Pisano MM, Roberts EA, Greene RM (Mar 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/s0014-5793(03)00155-8. PMID 12650946.

Further reading

External links


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