DUSP4

Dual specificity phosphatase 4
Identifiers
Symbols	DUSP4 ; HVH2; MKP-2; MKP2; TYP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1065
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dual specificity phosphatase 4, also known as DUSP4, is a human gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Further reading

• Guan KL, Butch E (1995). "Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase". J. Biol. Chem. 270 (13): 7197–203. PMID 7535768.
• King AG, Ozanne BW, Smythe C, Ashworth A (1996). "Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk". Oncogene. 11 (12): 2553–63. PMID 8545112.CS1 maint: Multiple names: authors list (link)
• Chu Y, Solski PA, Khosravi-Far R; et al. (1996). "The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation". J. Biol. Chem. 271 (11): 6497–501. PMID 8626452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Smith A, Price C, Cullen M; et al. (1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Husi H, Ward MA, Choudhary JS; et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen P, Hutter D, Yang X; et al. (2001). "Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically". J. Biol. Chem. 276 (31): 29440–9. doi:10.1074/jbc.M103463200. PMID 11387337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cadalbert L, Sloss CM, Cameron P, Plevin R (2005). "Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase". Cell. Signal. 17 (10): 1254–64. doi:10.1016/j.cellsig.2005.01.003. PMID 16038800.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tresini M, Lorenzini A, Torres C, Cristofalo VJ (2007). "Modulation of replicative senescence of diploid human cells by nuclear ERK signaling". J. Biol. Chem. 282 (6): 4136–51. doi:10.1074/jbc.M604955200. PMID 17145763.CS1 maint: Multiple names: authors list (link)
• Wang J, Shen WH, Jin YJ; et al. (2007). "A molecular link between E2F-1 and the MAPK cascade". J. Biol. Chem. 282 (25): 18521–31. doi:10.1074/jbc.M610538200. PMID 17452331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)