DRAP1

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Identifiers
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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.[1][2]

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.[2]

Interactions

DRAP1 has been shown to interact with FOXH1[3] and DR1.[4][5]

References

  1. Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, Landsman D, Levitt P, Tempst P, Reinberg D (May 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.
  2. 2.0 2.1 "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)".
  3. Iratni, Rabah; Yan Yu-Ting; Chen Canhe; Ding Jixiang; Zhang Yi; Price Sandy M; Reinberg Danny; Shen Michael M (Dec 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. United States. 298 (5600): 1996–9. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260.
  4. Mermelstein, F; Yeung K; Cao J; Inostroza J A; Erdjument-Bromage H; Eagelson K; Landsman D; Levitt P; Tempst P; Reinberg D (Apr 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. UNITED STATES. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. ISSN 0890-9369. PMID 8608938.
  5. Yeung, K; Kim S; Reinberg D (Jan 1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Mol. Cell. Biol. UNITED STATES. 17 (1): 36–45. ISSN 0270-7306. PMC 231727. PMID 8972183.

Further reading