DPP7

Dipeptidyl-peptidase 7
Identifiers
Symbols	DPP7 ; DPP2; DPPII; QPP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22748
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dipeptidyl-peptidase 7, also known as DPP7, is a human gene.

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Further reading

• Fornas E, Mayordomo F, Renau-Piqueras J, Alborch E (1992). "Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells". Histol. Histopathol. 7 (2): 163–8. PMID 1515698.CS1 maint: Multiple names: authors list (link)
• Roberts VJ, Gorenstein C (1990). "The effect of antimitotic agents on the intraneuronal distribution of lysosomes". Brain Res. 521 (1–2): 62–72. PMID 2207678.
• Andersen KJ, McDonald JK (1989). "Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides". Ren. Physiol. Biochem. 12 (1): 32–40. PMID 2727382.
• Demuth HU, Schlenzig D, Schierhorn A; et al. (1993). "Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases". FEBS Lett. 320 (1): 23–7. PMID 8096464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiravuri M, Schmitz T, Yardley K; et al. (1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J. Immunol. 163 (6): 3092–9. PMID 10477574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Underwood R, Chiravuri M, Lee H; et al. (1999). "Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase". J. Biol. Chem. 274 (48): 34053–8. PMID 10567372.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiravuri M, Agarraberes F, Mathieu SL; et al. (2000). "Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase". J. Immunol. 165 (10): 5695–702. PMID 11067927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukasawa KM, Fukasawa K, Higaki K; et al. (2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem. J. 353 (Pt 2): 283–90. PMID 11139392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Araki H, Li Y, Yamamoto Y; et al. (2001). "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase". J. Biochem. 129 (2): 279–88. PMID 11173530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhan H, Yamamoto Y, Shumiya S; et al. (2002). "Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats". Histochem. J. 33 (9–10): 511–21. PMID 12005022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leiting B, Pryor KD, Wu JK; et al. (2003). "Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII". Biochem. J. 371 (Pt 2): 525–32. doi:10.1042/BJ20021643. PMID 12529175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)