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Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene.   It encodes a protein that performs  posttranslational modification of histidine-715 on  eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.
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