DPAGT1

Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Identifiers
Symbols	DPAGT1 ; ALG7; CDG-Ij; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1058
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), also known as DPAGT1, is a human gene.

The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Freeze HH (2002). "Update and perspectives on congenital disorders of glycosylation". Glycobiology. 11 (12): 129R–143R. PMID 11805072.
• Freeze HH (2003). "Human disorders in N-glycosylation and animal models". Biochim. Biophys. Acta. 1573 (3): 388–93. PMID 12417423.
• Miller BS, Freeze HH (2003). "New disorders in carbohydrate metabolism: congenital disorders of glycosylation and their impact on the endocrine system". Reviews in endocrine & metabolic disorders. 4 (1): 103–13. PMID 12618564.
• Volpe JJ, Sakakihara Y, Ishii S (1987). "Dolichol-linked glycoprotein synthesis in developing mammalian brain: maturational changes of the N-acetylglucosaminylphosphotransferase". Brain Res. 430 (2): 277–84. PMID 3038274.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Smith MW, Clark SP, Hutchinson JS; et al. (1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. PMID 8244387.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eckert V, Blank M, Mazhari-Tabrizi R; et al. (1998). "Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae". Glycobiology. 8 (1): 77–85. PMID 9451016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meissner JD, Naumann A, Mueller WH, Scheibe RJ (1999). "Regulation of UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid in P19 cells". Biochem. J. 338 ( Pt 2): 561–8. PMID 10024536.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Regis S, Dagnino F, Caroli F, Filocamo M (2003). "Genomic structure of the human UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase gene". DNA Seq. 13 (5): 245–50. PMID 12592703.CS1 maint: Multiple names: authors list (link)
• Newell JW, Seo NS, Enns GM; et al. (2004). "Congenital disorder of glycosylation Ic in patients of Indian origin". Mol. Genet. Metab. 79 (3): 221–8. PMID 12855228.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu X, Rush JS, Karaoglu D; et al. (2004). "Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij". Hum. Mutat. 22 (2): 144–50. doi:10.1002/humu.10239. PMID 12872255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)