DNA polymerase beta

Polymerase (DNA directed), beta
	PDB rendering based on 1bno.
Available structures
PDB	Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
List of PDB id codes
	1bno, 1bnp, 1bpb, 1bpd, 1bpe, 1bpx, 1bpy, 1bpz, 1dk2, 1dk3, 1huo, 1huz, 1jn3, 1mq2, 1mq3, 1nom, 1rpl, 1tv9, 1tva, 1zjm, 1zjn, 1zqa, 1zqb, 1zqc, 1zqd, 1zqe, 1zqf, 1zqg, 1zqh, 1zqi, 1zqj, 1zqk, 1zql, 1zqm, 1zqn, 1zqo, 1zqp, 1zqq, 1zqr, 1zqs, 1zqt, 1zqu, 1zqv, 1zqw, 1zqx, 1zqy, 1zqz, 2bpc, 2bpf, 2bpg, 2fmp, 2fmq, 2fms, 2i9g, 2iso, 2isp, 2p66, 7ice, 7icf, 7icg, 7ich, 7ici, 7icj, 7ick, 7icl, 7icm, 7icn, 7ico, 7icp, 7icq, 7icr, 7ics, 7ict, 7icu, 7icv, 8ica, 8icb, 8icc, 8ice, 8icf, 8icg, 8ich, 8ici, 8icj, 8ick, 8icl, 8icm, 8icn, 8ico, 8icp, 8icq, 8icr, 8ics, 8ict, 8icu, 8icv, 8icw, 8icx, 8icy, 8icz, 9ica, 9icb, 9icc, 9ice, 9icf, 9icg, 9ich, 9ici, 9icj, 9ick, 9icl, 9icm, 9icn, 9ico, 9icp, 9icq, 9icr, 9ics, 9ict, 9icu, 9icv, 9icw, 9icx, 9icy
Identifiers
Symbols	POLB ; MGC125976
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2013
Gene ontology
Molecular function	Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Cellular component	Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Biological process	Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
	More reference expression data
Orthologs
	Template:GNF Ortholog box

Polymerase (DNA directed), beta, also known as POLB, is a human gene.^[1]

In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: POLB polymerase (DNA directed), beta".

Date T, Tanihara K, Yamamoto S; et al. (1992). "Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli". Nucleic Acids Res. 20 (18): 4859–64. PMID 1408801.
Wang L, Patel U, Ghosh L, Banerjee S (1992). "DNA polymerase beta mutations in human colorectal cancer". Cancer Res. 52 (17): 4824–7. PMID 1511447.
Tokui T, Inagaki M, Nishizawa K; et al. (1991). "Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.". J. Biol. Chem. 266 (17): 10820–4. PMID 2040602.
SenGupta DN, Zmudzka BZ, Kumar P; et al. (1986). "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning". Biochem. Biophys. Res. Commun. 136 (1): 341–7. PMID 2423078.
Zmudzka BZ, Fornace A, Collins J, Wilson SH (1988). "Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells". Nucleic Acids Res. 16 (20): 9587–96. PMID 2460824.
Widen SG, Kedar P, Wilson SH (1988). "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter". J. Biol. Chem. 263 (32): 16992–8. PMID 3182828.
Abbotts J, SenGupta DN, Zmudzka B; et al. (1988). "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme". Biochemistry. 27 (3): 901–9. PMID 3284575.
Dobashi Y, Kubota Y, Shuin T; et al. (1995). "Polymorphisms in the human DNA polymerase beta gene". Hum. Genet. 95 (4): 389–90. PMID 7705833.
Chyan YJ, Ackerman S, Shepherd NS; et al. (1994). "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression". Nucleic Acids Res. 22 (14): 2719–25. PMID 7914364.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
Chang M, Burmer GC, Sweasy J; et al. (1994). "Evidence against DNA polymerase beta as a candidate gene for Werner syndrome". Hum. Genet. 93 (5): 507–12. PMID 8168825.
Chyan YJ, Strauss PR, Wood TG, Wilson SH (1996). "Identification of novel mRNA isoforms for human DNA polymerase beta". DNA Cell Biol. 15 (8): 653–9. PMID 8769567.
Pelletier H, Sawaya MR, Wolfle W; et al. (1996). "Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity". Biochemistry. 35 (39): 12742–61. doi:10.1021/bi952955d. PMID 8841118.
Pelletier H, Sawaya MR, Wolfle W; et al. (1996). "A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta". Biochemistry. 35 (39): 12762–77. doi:10.1021/bi9529566. PMID 8841119.
Pelletier H, Sawaya MR (1996). "Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis". Biochemistry. 35 (39): 12778–87. doi:10.1021/bi960790i. PMID 8841120.
Kubota Y, Nash RA, Klungland A; et al. (1997). "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein". EMBO J. 15 (23): 6662–70. PMID 8978692.
Bennett RA, Wilson DM, Wong D, Demple B (1997). "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7166–9. PMID 9207062.
Sawaya MR, Prasad R, Wilson SH; et al. (1997). "Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism". Biochemistry. 36 (37): 11205–15. doi:10.1021/bi9703812. PMID 9287163.
Bhattacharyya N, Banerjee S (1997). "A variant of DNA polymerase beta acts as a dominant negative mutant". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10324–9. PMID 9294209.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.

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[entrez-1] 1.0 ^1.1 "Entrez Gene: POLB polymerase (DNA directed), beta".

[1]

DNA polymerase beta

References

Further reading

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