DNASE1L1: Difference between revisions

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{{Infobox_gene}}
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'''Deoxyribonuclease-1-like 1''' is an [[enzyme]] that in humans is encoded by the ''DNASE1L1'' [[gene]].<ref name="pmid8541839">{{cite journal | vauthors = Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL | title = A muscle-specific DNase I-like gene in human Xq28 | journal = Hum Mol Genet | volume = 4 | issue = 9 | pages = 1557–64 |date=Feb 1996 | pmid = 8541839 | pmc =  | doi =10.1093/hmg/4.9.1557 }}</ref><ref name="pmid8654957">{{cite journal | vauthors = Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I | title = Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region | journal = Gene | volume = 168 | issue = 2 | pages = 267–70 |date=Jul 1996 | pmid = 8654957 | pmc =  | doi =10.1016/0378-1119(95)00741-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1774| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deoxyribonuclease I-like 1
| HGNCid = 2957
| Symbol = DNASE1L1
| AltSymbols =; DNAS1L1; DNL1L; XIB
| OMIM = 300081
| ECnumber =
| Homologene = 4896
| MGIid = 109628
  | GeneAtlas_image1 = PBB_GE_DNASE1L1_203912_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004536 |text = deoxyribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
  | Process = {{GNF_GO|id=GO:0006308 |text = DNA catabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1774
    | Hs_Ensembl = ENSG00000013563
    | Hs_RefseqProtein = NP_001009932
    | Hs_RefseqmRNA = NM_001009932
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 153282773
    | Hs_GenLoc_end = 153293621
    | Hs_Uniprot = P49184
    | Mm_EntrezGene = 69537
    | Mm_Ensembl = ENSMUSG00000019088
    | Mm_RefseqmRNA = NM_027109
    | Mm_RefseqProtein = NP_081385
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70525938
    | Mm_GenLoc_end = 70535053
    | Mm_Uniprot = Q9D7J6
  }}
}}
'''Deoxyribonuclease I-like 1''', also known as '''DNASE1L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1774| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1774| accessdate = }}</ref>
| summary_text = This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Parrish JE, Ciccodicola A, Wehhert M, ''et al.'' |title=A muscle-specific DNase I-like gene in human Xq28. |journal=Hum. Mol. Genet. |volume=4 |issue= 9 |pages= 1557-64 |year= 1996 |pmid= 8541839 |doi= }}
*{{cite journal  | author=Chen EY |title=Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 659–68 |year= 1997 |pmid= 8733135 |doi=10.1093/hmg/5.5.659 |name-list-format=vanc| author2=Zollo M  | author3=Mazzarella R  | display-authors=3  | last4=Ciccodicola  | first4=A  | last5=Chen | first5=CN  | last6=Zuo  | first6=L  | last7=Heiner  | first7=C  | last8=Burough  | first8=F  | last9=Repetto  | first9=M }}
*{{cite journal | author=Pergolizzi R, Appierto V, Bosetti A, ''et al.'' |title=Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region. |journal=Gene |volume=168 |issue= 2 |pages= 267-70 |year= 1996 |pmid= 8654957 |doi= }}
*{{cite journal  | author=Rodriguez AM |title=Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I |journal=Genomics |volume=42 |issue= 3 |pages= 507–13 |year= 1997 |pmid= 9205125 |doi= 10.1006/geno.1997.4748 |name-list-format=vanc| author2=Rodin D  | author3=Nomura H  | display-authors=3  | last4=Morton  | first4=Cynthia C.  | last5=Weremowicz  | first5=Stanislawa  | last6=Schneider  | first6=Michael C. }}
*{{cite journal | author=Chen EY, Zollo M, Mazzarella R, ''et al.'' |title=Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 659-68 |year= 1997 |pmid= 8733135 |doi=  }}
*{{cite journal  | author=Malferrari G |title=Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders |journal=Exp. Mol. Pathol. |volume=66 |issue= 2 |pages= 123–30 |year= 1999 |pmid= 10409440 |doi= 10.1006/exmp.1999.2254 |name-list-format=vanc| author2=Mazza U  | author3=Tresoldi C  | display-authors=3  | last4=Rovida  | first4=E  | last5=Nissim  | first5=M  | last6=Mirabella  | first6=M  | last7=Servidei  | first7=S  | last8=Biunno  | first8=I }}
*{{cite journal  | author=Rodriguez AM, Rodin D, Nomura H, ''et al.'' |title=Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. |journal=Genomics |volume=42 |issue= 3 |pages= 507-13 |year= 1997 |pmid= 9205125 |doi= 10.1006/geno.1997.4748 }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Malferrari G, Mazza U, Tresoldi C, ''et al.'' |title=Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders. |journal=Exp. Mol. Pathol. |volume=66 |issue= 2 |pages= 123-30 |year= 1999 |pmid= 10409440 |doi= 10.1006/exmp.1999.2254 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |name-list-format=vanc| author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286  |name-list-format=vanc| author2=Grafham DV  | author3=Coffey AJ  | display-authors=3  | last4=Scherer  | first4=Steven  | last5=McLay  | first5=Kirsten  | last6=Muzny  | first6=Donna  | last7=Platzer  | first7=Matthias  | last8=Howell  | first8=Gareth R.  | last9=Burrows  | first9=Christine }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Shiokawa D |title=Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 511–7 |year= 2006 |pmid= 16107205 |doi= 10.1042/BJ20051114 | pmc=1316290  |name-list-format=vanc| author2=Shika Y  | author3=Saito K  | display-authors=3  | last4=Yamazaki  | first4=Kosuke  | last5=Tanuma  | first5=Sei-Ichi }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Shiokawa D, Shika Y, Saito K, ''et al.'' |title=Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X. |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 511-7 |year= 2006 |pmid= 16107205 |doi= 10.1042/BJ20051114 }}
*{{cite journal  | author=Coy JF |title=Isolation, differential splicing and protein expression of a DNase on the human X chromosome |journal=Cell Death Differ. |volume=3 |issue= 2 |pages= 199–206 |year=  1996|pmid= 17180083 |doi= |name-list-format=vanc| author2=Velhagen I  | author3=Himmele R  | display-authors=3  | last4=Delius  | first4=H  | last5=Poustka  | first5=A  | last6=Zentgraf  | first6=H }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Coy JF, Velhagen I, Himmele R, ''et al.'' |title=Isolation, differential splicing and protein expression of a DNase on the human X chromosome. |journal=Cell Death Differ. |volume=3 |issue= 2 |pages= 199-206 |year=  |pmid= 17180083 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:38, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene.[1][2][3]

This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.[3]

References

  1. ↑ Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL (Feb 1996). "A muscle-specific DNase I-like gene in human Xq28". Hum Mol Genet. 4 (9): 1557–64. doi:10.1093/hmg/4.9.1557. PMID 8541839.
  2. ↑ Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I (Jul 1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region". Gene. 168 (2): 267–70. doi:10.1016/0378-1119(95)00741-5. PMID 8654957.
  3. ↑ 3.0 3.1 "Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1".

Further reading



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