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Dynein light chain 1, axonemal is a protein that in humans is encoded by the DNAL1 gene .[1] [2]
Function DNAL1 is a component of outer dynein arms, which contain the molecular motors for ATP -dependent cilia movement.[1] [2]
Clinical significance Mutations in the DNAL1 gene are associated with primary ciliary dyskinesia .[3]
References
↑ 1.0 1.1 "Entrez Gene: dynein" .↑ 2.0 2.1 Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, Fekete G, Neesen J, Reinhardt R, Omran H (July 2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol . 33 (1): 41–7. doi :10.1165/rcmb.2004-0335OC . PMID 15845866 . ↑ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease" . Curr. Opin. Genet. Dev . 19 (3): 220–9. doi :10.1016/j.gde.2009.04.008 . PMC 2953615 PMID 19477114 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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