DLGAP4: Difference between revisions

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{{Infobox_gene}}
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
'''Disks large-associated protein 4''' (DAP-4) also known as '''SAP90/PSD-95-associated protein 4''' (SAPAP-4) is a [[protein]] that in humans is encoded by the ''DLGAP4'' [[gene]].<ref name="pmid9115257">{{cite journal |vauthors=Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y | title = SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density | journal = J Biol Chem | volume = 272 | issue = 18 | pages = 11943–51 |date=Jun 1997 | pmid = 9115257 | pmc =  | doi =10.1074/jbc.272.18.11943 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22839| accessdate = }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Discs, large (Drosophila) homolog-associated protein 4
| HGNCid = 24476
| Symbol = DLGAP4
| AltSymbols =; DAP4; KIAA0964; MGC131862; RP5-977B1.6; SAPAP4
| OMIM =
| ECnumber =
| Homologene = 8935
| MGIid = 2138865
  | GeneAtlas_image1 = PBB_GE_DLGAP4_202570_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DLGAP4_202571_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DLGAP4_202572_s_at_tn.png
| Function =
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}}  
| Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22839
    | Hs_Ensembl = ENSG00000080845
    | Hs_RefseqProtein = NP_001035951
    | Hs_RefseqmRNA = NM_001042486
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 34357672
    | Hs_GenLoc_end = 34590454
    | Hs_Uniprot = Q9Y2H0
    | Mm_EntrezGene = 228836
    | Mm_Ensembl = ENSMUSG00000061689
    | Mm_RefseqmRNA = NM_001042487
    | Mm_RefseqProtein = NP_001035952
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 156392093
    | Mm_GenLoc_end = 156455804
    | Mm_Uniprot = 
  }}
}}
'''Discs, large (Drosophila) homolog-associated protein 4''', also known as '''DLGAP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22839| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
 
| section_title =
DAP-4 is a membrane-associated [[guanylate kinase]] found at the [[chemical synapse|postsynaptic]] density in [[neuron|neuronal cells]]. It is a signaling molecule that can interact with [[potassium channel]]s and [[receptor (biochemistry)|receptors]], as well as other signaling molecules. DAP-4 can interact with [[DLG4|PSD-95]] through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
| summary_text = The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22839| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Kim JH, Liao D, Lau LF, Huganir RL |title=SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family |journal=Neuron |volume=20 |issue= 4 |pages= 683–91 |year= 1998 |pmid= 9581761 |doi=10.1016/S0896-6273(00)81008-9 }}
| citations =
*{{cite journal  |vauthors=Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB |title=A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II |journal=Neuron |volume=20 |issue= 5 |pages= 895–904 |year= 1998 |pmid= 9620694 |doi=10.1016/S0896-6273(00)80471-7 }}
*{{cite journal  | author=Takeuchi M, Hata Y, Hirao K, ''et al.'' |title=SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11943-51 |year= 1997 |pmid= 9115257 |doi=  }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63  |name-list-format=vanc| author2=Ishikawa K  | author3=Suyama M  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Hirosawa  | first5=M  | last6=Miyajima  | first6=N  | last7=Tanaka  | first7=A  | last8=Kotani  | first8=H  | last9=Nomura  | first9=N }}
*{{cite journal  | author=Kim JH, Liao D, Lau LF, Huganir RL |title=SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. |journal=Neuron |volume=20 |issue= 4 |pages= 683-91 |year= 1998 |pmid= 9581761 |doi=  }}
*{{cite journal  | author=Kawabe H |title=nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30914–8 |year= 1999 |pmid= 10521485 |doi=10.1074/jbc.274.43.30914  |name-list-format=vanc| author2=Hata Y  | author3=Takeuchi M  | display-authors=3  | last4=Ide  | first4=N  | last5=Mizoguchi  | first5=A  | last6=Takai  | first6=Y }}
*{{cite journal  | author=Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB |title=A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. |journal=Neuron |volume=20 |issue= 5 |pages= 895-904 |year= 1998 |pmid= 9620694 |doi=  }}
*{{cite journal  | author=Husi H |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 |name-list-format=vanc| author2=Ward MA  | author3=Choudhary JS  | display-authors=3  | last4=Choudhary  | first4=Jyoti S.  | last5=Blackstock  | first5=Walter P. }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63-70 |year= 1999 |pmid= 10231032 |doi=  }}
*{{cite journal  |vauthors=Pei L, Teves RL, Wallace MC, Gurd JW |title=Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP |journal=J. Cereb. Blood Flow Metab. |volume=21 |issue= 8 |pages= 955–63 |year= 2001 |pmid= 11487731 |doi= 10.1097/00004647-200108000-00008 }}
*{{cite journal  | author=Kawabe H, Hata Y, Takeuchi M, ''et al.'' |title=nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30914-8 |year= 1999 |pmid= 10521485 |doi=  }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Husi H, Ward MA, Choudhary JS, ''et al.'' |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661-9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Pei L, Teves RL, Wallace MC, Gurd JW |title=Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. |journal=J. Cereb. Blood Flow Metab. |volume=21 |issue= 8 |pages= 955-63 |year= 2001 |pmid= 11487731 |doi= 10.1097/00004647-200108000-00008 }}
*{{cite journal  | author=Riefler GM |title=Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor) |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 49–55 |year= 2003 |pmid= 12675619 |doi= 10.1042/BJ20021838 | pmc=1223477  |name-list-format=vanc| author2=Balasingam G  | author3=Lucas KG  | display-authors=3  | last4=Wang  | first4=Sheng  | last5=Hsu  | first5=Shu-Chan  | last6=Firestein  | first6=Bonnie L. }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Song B, Yan XB, Zhang GY |title=PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus |journal=Brain Res. |volume=1005 |issue= 1–2 |pages= 44–50 |year= 2004 |pmid= 15044063 |doi= 10.1016/j.brainres.2004.01.032 }}
*{{cite journal  | author=Riefler GM, Balasingam G, Lucas KG, ''et al.'' |title=Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 49-55 |year= 2003 |pmid= 12675619 |doi= 10.1042/BJ20021838 }}
*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |name-list-format=vanc| author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Song B, Yan XB, Zhang GY |title=PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. |journal=Brain Res. |volume=1005 |issue= 1-2 |pages= 44-50 |year= 2004 |pmid= 15044063 |doi= 10.1016/j.brainres.2004.01.032 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:31, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.[1][2]

Function

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
  2. ↑ 2.0 2.1 "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4".

Further reading


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