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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Diacylglycerol kinase gamma''' is an [[enzyme]] that in humans is encoded by the ''DGKG'' [[gene]].<ref name="pmid8034597">{{cite journal | vauthors = Kai M, Sakane F, Imai S, Wada I, Kanoh H | title = Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in [[human retina]] with a truncated and inactive enzyme expression in most other human cells | journal = J Biol Chem | volume = 269 | issue = 28 | pages = 18492–8 |date=Aug 1994 | pmid = 8034597 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1608| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Diacylglycerol kinase, gamma 90kDa
| HGNCid = 2853
| Symbol = DGKG
| AltSymbols =; DAGK3; DGK-GAMMA; MGC104993; MGC133330
| OMIM = 601854
| ECnumber = 
| Homologene = 1029
| MGIid = 105060
| GeneAtlas_image1 = PBB_GE_DGKG_206395_at_tn.png
| Function = {{GNF_GO|id=GO:0004143 |text = diacylglycerol kinase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}}
  | Component =  
  | Process = {{GNF_GO|id=GO:0007205 |text = protein kinase C activation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1608
    | Hs_Ensembl = ENSG00000058866
    | Hs_RefseqProtein = NP_001074213
    | Hs_RefseqmRNA = NM_001080744
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 187349706
    | Hs_GenLoc_end = 187562697
    | Hs_Uniprot = P49619
    | Mm_EntrezGene = 110197
    | Mm_Ensembl = ENSMUSG00000022861
    | Mm_RefseqmRNA = NM_138650
    | Mm_RefseqProtein = NP_619591
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 22383717
    | Mm_GenLoc_end = 22572477
    | Mm_Uniprot = Q8C248
  }}
}}
'''Diacylglycerol kinase, gamma 90kDa''', also known as '''DGKG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1608| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1608| accessdate = }}</ref>
| summary_text = This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Brose N, Betz A, Wegmeyer H |title=Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 328-40 |year= 2004 |pmid= 15194113 |doi= 10.1016/j.conb.2004.05.006 }}
*{{cite journal  | vauthors=Brose N, Betz A, Wegmeyer H |title=Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 328–40 |year= 2004 |pmid= 15194113 |doi= 10.1016/j.conb.2004.05.006 }}
*{{cite journal  | author=Luo B, Regier DS, Prescott SM, Topham MK |title=Diacylglycerol kinases. |journal=Cell. Signal. |volume=16 |issue= 9 |pages= 983-9 |year= 2005 |pmid= 15212759 |doi= 10.1016/j.cellsig.2004.03.016 }}
*{{cite journal  | vauthors=Luo B, Regier DS, Prescott SM, Topham MK |title=Diacylglycerol kinases. |journal=Cell. Signal. |volume=16 |issue= 9 |pages= 983–9 |year= 2005 |pmid= 15212759 |doi= 10.1016/j.cellsig.2004.03.016 }}
*{{cite journal  | author=Topham MK |title=Signaling roles of diacylglycerol kinases. |journal=J. Cell. Biochem. |volume=97 |issue= 3 |pages= 474-84 |year= 2006 |pmid= 16288460 |doi= 10.1002/jcb.20704 }}
*{{cite journal  | author=Topham MK |title=Signaling roles of diacylglycerol kinases. |journal=J. Cell. Biochem. |volume=97 |issue= 3 |pages= 474–84 |year= 2006 |pmid= 16288460 |doi= 10.1002/jcb.20704 }}
*{{cite journal  | author=Kai M, Sakane F, Imai S, ''et al.'' |title=Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. |journal=J. Biol. Chem. |volume=269 |issue= 28 |pages= 18492-8 |year= 1994 |pmid= 8034597 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Yamada K, Sakane F, Matsushima N, Kanoh H |title=EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes. | series=321 |journal=Biochem. J. |volume=( Pt 1) |issue=  |pages= 59–64 |year= 1997 |pmid= 9003401 |doi= | pmc=1218036 }}
*{{cite journal  | author=Yamada K, Sakane F, Matsushima N, Kanoh H |title=EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes. |journal=Biochem. J. |volume=321 ( Pt 1) |issue=  |pages= 59-64 |year= 1997 |pmid= 9003401 |doi=  }}
*{{cite journal  | vauthors=Stöhr H, Klein J, Gehrig A |title=Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). |journal=Hum. Genet. |volume=104 |issue= 1 |pages= 99–105 |year= 1999 |pmid= 10071200 |doi=10.1007/s004390050917 |display-authors=etal}}
*{{cite journal  | author=Stöhr H, Klein J, Gehrig A, ''et al.'' |title=Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). |journal=Hum. Genet. |volume=104 |issue= 1 |pages= 99-105 |year= 1999 |pmid= 10071200 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Yamada K, Sakane F, Imai S |title=Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 101–7 |year= 2003 |pmid= 12732202 |doi=10.1016/S0006-291X(03)00713-7 |display-authors=etal}}
*{{cite journal  | author=Yamada K, Sakane F, Imai S, ''et al.'' |title=Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 101-7 |year= 2003 |pmid= 12732202 |doi=  }}
*{{cite journal  | vauthors=Oyaizu K, Kantarci A, Maeda H |title=Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. |journal=J. Periodont. Res. |volume=38 |issue= 5 |pages= 488–95 |year= 2003 |pmid= 12941073 |doi=10.1034/j.1600-0765.2003.00680.x |display-authors=etal}}
*{{cite journal  | author=Oyaizu K, Kantarci A, Maeda H, ''et al.'' |title=Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. |journal=J. Periodont. Res. |volume=38 |issue= 5 |pages= 488-95 |year= 2003 |pmid= 12941073 |doi=  }}
*{{cite journal  | vauthors=Tsushima S, Kai M, Yamada K |title=Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28603–13 |year= 2004 |pmid= 15102830 |doi= 10.1074/jbc.M314031200 |display-authors=etal}}
*{{cite journal  | author=Tsushima S, Kai M, Yamada K, ''et al.'' |title=Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28603-13 |year= 2004 |pmid= 15102830 |doi= 10.1074/jbc.M314031200 }}
*{{cite journal  | vauthors=Filosto M, Mancuso M, Tomelleri G |title=Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation. |journal=Acta Neuropathol. |volume=108 |issue= 2 |pages= 168–71 |year= 2004 |pmid= 15150663 |doi= 10.1007/s00401-004-0872-9 |display-authors=etal}}
*{{cite journal  | author=Filosto M, Mancuso M, Tomelleri G, ''et al.'' |title=Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation. |journal=Acta Neuropathol. |volume=108 |issue= 2 |pages= 168-71 |year= 2004 |pmid= 15150663 |doi= 10.1007/s00401-004-0872-9 }}
*{{cite journal  | vauthors=Batista EL, Warbington M, Badwey JA, Van Dyke TE |title=Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). |journal=J. Cell. Biochem. |volume=94 |issue= 4 |pages= 774–93 |year= 2005 |pmid= 15578578 |doi= 10.1002/jcb.20356 }}
*{{cite journal  | author=Batista EL, Warbington M, Badwey JA, Van Dyke TE |title=Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). |journal=J. Cell. Biochem. |volume=94 |issue= 4 |pages= 774-93 |year= 2005 |pmid= 15578578 |doi= 10.1002/jcb.20356 }}
*{{cite journal  | vauthors=Matsubara T, Shirai Y, Miyasaka K |title=Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus. |journal=J. Biol. Chem. |volume=281 |issue= 10 |pages= 6152–64 |year= 2006 |pmid= 16407189 |doi= 10.1074/jbc.M509873200 |display-authors=etal}}
*{{cite journal  | author=Matsubara T, Shirai Y, Miyasaka K, ''et al.'' |title=Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus. |journal=J. Biol. Chem. |volume=281 |issue= 10 |pages= 6152-64 |year= 2006 |pmid= 16407189 |doi= 10.1074/jbc.M509873200 }}
*{{cite journal  | vauthors=Yamaguchi Y, Shirai Y, Matsubara T |title=Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31627–37 |year= 2006 |pmid= 16905533 |doi= 10.1074/jbc.M606992200 |display-authors=etal}}
*{{cite journal  | author=Yamaguchi Y, Shirai Y, Matsubara T, ''et al.'' |title=Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31627-37 |year= 2006 |pmid= 16905533 |doi= 10.1074/jbc.M606992200 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:EF-hand-containing proteins]]

Latest revision as of 17:08, 27 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.[1][2]

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Kai M, Sakane F, Imai S, Wada I, Kanoh H (Aug 1994). "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells". J Biol Chem. 269 (28): 18492–8. PMID 8034597.
  2. ↑ 2.0 2.1 "Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa".

Further reading



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