DEK (gene)

DEK oncogene (DNA binding)
PDB rendering based on 1q1v.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q1v​
Identifiers
Symbols	DEK ; D6S231E
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2593
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

DEK oncogene (DNA binding), also known as DEK, is a human gene.

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.

Further reading

• von Lindern M, Fornerod M, Soekarman N; et al. (1993). "Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene". Baillieres Clin. Haematol. 5 (4): 857–79. PMID 1308167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waldmann T, Scholten I, Kappes F; et al. (2005). "The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin". Gene. 343 (1): 1–9. doi:10.1016/j.gene.2004.08.029. PMID 15563827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• von Lindern M, Fornerod M, van Baal S; et al. (1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. PMID 1549122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denisenko ON, O'Neill B, Ostrowski J; et al. (1996). "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein". J. Biol. Chem. 271 (44): 27701–6. PMID 8910362.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu GK, Grosveld G, Markovitz DM (1997). "DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1811–5. PMID 9050861.CS1 maint: Multiple names: authors list (link)
• Murray KJ, Szer W, Grom AA; et al. (1997). "Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene". J. Rheumatol. 24 (3): 560–7. PMID 9058666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forero L, Zwirner NW, Fink CW; et al. (1999). "Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides". Hum. Immunol. 59 (7): 443–50. PMID 9684994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dong X, Michelis MA, Wang J; et al. (1998). "Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis". Arthritis Rheum. 41 (8): 1505–10. doi:10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N. PMID 9704652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wichmann I, Garcia-Lozano JR, Respaldiza N; et al. (1999). "Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus". Hum. Immunol. 60 (1): 57–62. PMID 9952027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alexiadis V, Waldmann T, Andersen J; et al. (2000). "The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner". Genes Dev. 14 (11): 1308–12. PMID 10837023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McGarvey T, Rosonina E, McCracken S; et al. (2000). "The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes". J. Cell Biol. 150 (2): 309–20. PMID 10908574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grottke C, Mantwill K, Dietel M; et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. PMID 11058868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2001). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMID 11118221.CS1 maint: Multiple names: authors list (link)
• Kappes F, Burger K, Baack M; et al. (2001). "Subcellular localization of the human proto-oncogene protein DEK". J. Biol. Chem. 276 (28): 26317–23. doi:10.1074/jbc.M100162200. PMID 11333257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waldmann T, Eckerich C, Baack M, Gruss C (2002). "The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils". J. Biol. Chem. 277 (28): 24988–94. doi:10.1074/jbc.M204045200. PMID 11997399.CS1 maint: Multiple names: authors list (link)
• Larramendy ML, Niini T, Elonen E; et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID 12031912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hollenbach AD, McPherson CJ, Mientjes EJ; et al. (2003). "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek". J. Cell. Sci. 115 (Pt 16): 3319–30. PMID 12140263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krithivas A, Fujimuro M, Weidner M; et al. (2002). "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes". J. Virol. 76 (22): 11596–604. PMID 12388720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)