DDX6: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Probable ATP-dependent RNA helicase DDX6''' is an [[enzyme]] that in humans is encoded by the ''DDX6'' [[gene]].<ref name="pmid1579499">{{cite journal | vauthors = Lu D, Yunis JJ | title = Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3 | journal = Nucleic Acids Res | volume = 20 | issue = 8 | pages = 1967–72 |date=Jun 1992 | pmid = 1579499 | pmc = 312313 | doi =10.1093/nar/20.8.1967 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1656| accessdate = }}</ref>
| image = PBB_Protein_DDX6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vec.
| PDB = {{PDB2|1vec}}
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
| HGNCid = 2747
| Symbol = DDX6
| AltSymbols =; FLJ36338; HLR2; P54; RCK
| OMIM = 600326
| ECnumber = 
| Homologene = 3238
| MGIid = 104976
| GeneAtlas_image1 = PBB_GE_DDX6_204909_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1656
    | Hs_Ensembl = ENSG00000110367
    | Hs_RefseqProtein = NP_004388
    | Hs_RefseqmRNA = NM_004397
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 118125623
    | Hs_GenLoc_end = 118167082
    | Hs_Uniprot = P26196
    | Mm_EntrezGene = 13209
    | Mm_Ensembl = ENSMUSG00000032097
    | Mm_RefseqmRNA = NM_007841
    | Mm_RefseqProtein = NP_031867
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 44355893
    | Mm_GenLoc_end = 44388175
    | Mm_Uniprot = O54979
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 6''', also known as '''DDX6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1656| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1656| accessdate = }}</ref>
| summary_text = [[DEAD box]] proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of [[RNA secondary structure]] such as translation initiation, nuclear and mitochondrial splicing, and [[ribosome]] and [[spliceosome]] assembly. Based on their distribution patterns, some members of this family are believed to be involved in [[embryogenesis]], [[spermatogenesis]], and [[cellular growth]] and division. This gene encodes a DEAD box protein. It may contribute to the [[cell proliferation]] and [[carcinogenesis]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Akao Y, Seto M, Yamamoto K, ''et al.'' |title=The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. |journal=Cancer Res. |volume=52 |issue= 21 |pages= 6083-7 |year= 1992 |pmid= 1394235 |doi=  }}
*{{cite journal  | vauthors=Akao Y, Seto M, Yamamoto K |title=The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations |journal=Cancer Res. |volume=52 |issue= 21 |pages= 6083–7 |year= 1992 |pmid= 1394235 |doi=  |display-authors=etal}}
*{{cite journal  | author=Lu D, Yunis JJ |title=Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. |journal=Nucleic Acids Res. |volume=20 |issue= 8 |pages= 1967-72 |year= 1992 |pmid= 1579499 |doi= }}
*{{cite journal  | vauthors=Akao Y, Marukawa O, Morikawa H |title=The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues |journal=Cancer Res. |volume=55 |issue= 15 |pages= 3444–9 |year= 1995 |pmid= 7614484 |doi=  |display-authors=etal}}
*{{cite journal  | author=Akao Y, Marukawa O, Morikawa H, ''et al.'' |title=The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. |journal=Cancer Res. |volume=55 |issue= 15 |pages= 3444-9 |year= 1995 |pmid= 7614484 |doi=  }}
*{{cite journal  | vauthors=Zhang WJ, Wu JY |title=Functional properties of p54, a novel SR protein active in constitutive and alternative splicing |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5400–8 |year= 1996 |pmid= 8816452 |doi= | pmc=231539 }}
*{{cite journal  | author=Zhang WJ, Wu JY |title=Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5400-8 |year= 1996 |pmid= 8816452 |doi=  }}
*{{cite journal  | vauthors=Akiyama K, Akao Y, Yokoyama M |title=Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 4 |pages= 563–8 |year= 1999 |pmid= 10319407 |doi=  10.1080/15216549900201603|display-authors=etal}}
*{{cite journal  | author=Akiyama K, Akao Y, Yokoyama M, ''et al.'' |title=Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines. |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 4 |pages= 563-8 |year= 1999 |pmid= 10319407 |doi=  }}
*{{cite journal  | vauthors=Nakagawa Y, Morikawa H, Hirata I |title=Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours |journal=Br. J. Cancer |volume=80 |issue= 5–6 |pages= 914–7 |year= 1999 |pmid= 10360675 |doi= 10.1038/sj.bjc.6690441 | pmc=2362290 |display-authors=etal}}
*{{cite journal  | author=Nakagawa Y, Morikawa H, Hirata I, ''et al.'' |title=Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours. |journal=Br. J. Cancer |volume=80 |issue= 5-6 |pages= 914-7 |year= 1999 |pmid= 10360675 |doi= 10.1038/sj.bjc.6690441 }}
*{{cite journal  | vauthors=Smillie DA, Sommerville J |title=RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles |journal=J. Cell Sci. |volume=115 |issue= Pt 2 |pages= 395–407 |year= 2002 |pmid= 11839790 |doi=  }}
*{{cite journal  | author=Smillie DA, Sommerville J |title=RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. |journal=J. Cell. Sci. |volume=115 |issue= Pt 2 |pages= 395-407 |year= 2002 |pmid= 11839790 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Miyaji K, Nakagawa Y, Matsumoto K |title=Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis |journal=J. Viral Hepat. |volume=10 |issue= 4 |pages= 241–8 |year= 2003 |pmid= 12823589 |doi=10.1046/j.1365-2893.2003.00447.x |display-authors=etal}}
*{{cite journal  | author=Miyaji K, Nakagawa Y, Matsumoto K, ''et al.'' |title=Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis. |journal=J. Viral Hepat. |volume=10 |issue= 4 |pages= 241-8 |year= 2003 |pmid= 12823589 |doi=  }}
*{{cite journal  | vauthors=Matsui T, Hogetsu K, Akao Y |title=Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54 |journal=Acta Crystallogr. D |volume=60 |issue= Pt 1 |pages= 156–9 |year= 2004 |pmid= 14684915 |doi=10.1107/S0907444903024223 |display-authors=etal}}
*{{cite journal  | author=Matsui T, Hogetsu K, Akao Y, ''et al.'' |title=Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 1 |pages= 156-9 |year= 2004 |pmid= 14684915 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905–15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | author=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905-15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | vauthors=Matsui T, Hogetsu K, Usukura J |title=Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes |journal=Genes Cells |volume=11 |issue= 4 |pages= 439–52 |year= 2006 |pmid= 16611246 |doi= 10.1111/j.1365-2443.2006.00951.x |display-authors=etal}}
*{{cite journal  | author=Matsui T, Hogetsu K, Usukura J, ''et al.'' |title=Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes. |journal=Genes Cells |volume=11 |issue= 4 |pages= 439-52 |year= 2006 |pmid= 16611246 |doi= 10.1111/j.1365-2443.2006.00951.x }}
*{{cite journal  | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 }}
*{{cite journal  | author=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 }}
*{{cite journal  | vauthors=Chu CY, Rana TM |title=Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54 |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210 | pmc=1475773 }}
*{{cite journal  | author=Chu CY, Rana TM |title=Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | vauthors=Nonhoff U, Ralser M, Welzel F |title=Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1385–96 |year= 2007 |pmid= 17392519 |doi= 10.1091/mbc.E06-12-1120 | pmc=1838996 |display-authors=etal}}
*{{cite journal  | author=Nonhoff U, Ralser M, Welzel F, ''et al.'' |title=Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1385-96 |year= 2007 |pmid= 17392519 |doi= 10.1091/mbc.E06-12-1120 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1656}}
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{{protein-stub}}
{{gene-11-stub}}
{{WikiDoc Sources}}

Latest revision as of 21:27, 13 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.[2]

References

  1. ↑ Lu D, Yunis JJ (Jun 1992). "Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3". Nucleic Acids Res. 20 (8): 1967–72. doi:10.1093/nar/20.8.1967. PMC 312313. PMID 1579499.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6".

Further reading



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