DDX39: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''ATP-dependent RNA helicase DDX39''' is an [[enzyme]] that in humans is encoded by the ''DDX39'' [[gene]].<ref name="pmid7601445">{{cite journal | vauthors = Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y | title = The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family | journal = Genomics | volume = 26 | issue = 2 | pages = 210–8 |date=Aug 1995 | pmid = 7601445 | pmc =  | doi =10.1016/0888-7543(95)80203-X |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10212| accessdate = }}</ref>
| image = PBB_Protein_DDX39_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t5i.
| PDB = {{PDB2|1t5i}}, {{PDB2|1t6n}}, {{PDB2|1xti}}, {{PDB2|1xtj}}, {{PDB2|1xtk}}
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
| HGNCid = 17821
| Symbol = DDX39
| AltSymbols =; BAT1; BAT1L; DDXL; MGC18203; MGC8417; URH49
| OMIM =
| ECnumber =
| Homologene = 68487
| MGIid = 1915528
  | GeneAtlas_image1 = PBB_GE_DDX39_201584_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0006406 |text = mRNA export from nucleus}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10212
    | Hs_Ensembl = ENSG00000123136
    | Hs_RefseqProtein = NP_005795
    | Hs_RefseqmRNA = NM_005804
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 14380632
    | Hs_GenLoc_end = 14391171
    | Hs_Uniprot = O00148
    | Mm_EntrezGene = 68278
    | Mm_Ensembl = ENSMUSG00000005481
    | Mm_RefseqmRNA = NM_197982
    | Mm_RefseqProtein = NP_932099
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 86605304
    | Mm_GenLoc_end = 86613453
    | Mm_Uniprot = Q3T9L0
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 39''', also known as '''DDX39''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10212| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.<ref name="entrez">{{cite web | title = Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10212| accessdate = }}</ref>
| summary_text = This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Peelman LJ, Chardon P, Nunes M, ''et al.'' |title=The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. |journal=Genomics |volume=26 |issue= 2 |pages= 210-8 |year= 1995 |pmid= 7601445 |doi=  }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | vauthors=Strässer K, Masuda S, Mason P |title=TREX is a conserved complex coupling transcription with messenger RNA export. |journal=Nature |volume=417 |issue= 6886 |pages= 304–8 |year= 2002 |pmid= 11979277 |doi= 10.1038/nature746 |display-authors=etal}}
*{{cite journal  | author=Strässer K, Masuda S, Mason P, ''et al.'' |title=TREX is a conserved complex coupling transcription with messenger RNA export. |journal=Nature |volume=417 |issue= 6886 |pages= 304-8 |year= 2002 |pmid= 11979277 |doi= 10.1038/417304a }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |display-authors=etal}}
*{{cite journal  | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Pryor A, Tung L, Yang Z |title=Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. |journal=Nucleic Acids Res. |volume=32 |issue= 6 |pages= 1857–65 |year= 2004 |pmid= 15047853 |doi= 10.1093/nar/gkh347 | pmc=390356 |display-authors=etal}}
*{{cite journal  | author=Pryor A, Tung L, Yang Z, ''et al.'' |title=Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. |journal=Nucleic Acids Res. |volume=32 |issue= 6 |pages= 1857-65 |year= 2004 |pmid= 15047853 |doi= 10.1093/nar/gkh347 }}
*{{cite journal  | vauthors=Leaw CL, Ren EC, Choong ML |title=Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 17 |pages= 2264–73 |year= 2004 |pmid= 15338056 |doi= 10.1007/s00018-004-4205-x }}
*{{cite journal  | author=Leaw CL, Ren EC, Choong ML |title=Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 17 |pages= 2264-73 |year= 2004 |pmid= 15338056 |doi= 10.1007/s00018-004-4205-x }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Kapadia F, Pryor A, Chang TH, Johnson LF |title=Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. |journal=Gene |volume=384 |issue=  |pages= 37–44 |year= 2007 |pmid= 16949217 |doi= 10.1016/j.gene.2006.07.010 }}
*{{cite journal  | author=Kapadia F, Pryor A, Chang TH, Johnson LF |title=Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. |journal=Gene |volume=384 |issue=  |pages= 37-44 |year= 2007 |pmid= 16949217 |doi= 10.1016/j.gene.2006.07.010 }}
*{{cite journal  | vauthors=Sugiura T, Sakurai K, Nagano Y |title=Intracellular characterization of DDX39, a novel growth-associated RNA helicase. |journal=Exp. Cell Res. |volume=313 |issue= 4 |pages= 782–90 |year= 2007 |pmid= 17196963 |doi= 10.1016/j.yexcr.2006.11.014 }}
*{{cite journal  | author=Sugiura T, Sakurai K, Nagano Y |title=Intracellular characterization of DDX39, a novel growth-associated RNA helicase. |journal=Exp. Cell Res. |volume=313 |issue= 4 |pages= 782-90 |year= 2007 |pmid= 17196963 |doi= 10.1016/j.yexcr.2006.11.014 }}
*{{cite journal  | vauthors=Quaresma AJ, Sievert R, Nickerson JA |title=Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. |journal=Mol. Biol. Cell |volume= 24|issue= 8 |pages= 1208–21 |year= 2013 |pmid= 23427269 |doi= 10.1091/mbc.E12-06-0450  | pmc=3623641 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|DDX39A}}
* {{UCSC gene details|DDX39A}}
 
{{PDB Gallery|geneid=10212}}
 
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Revision as of 18:19, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.[1][2]

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.[2]

References

  1. ↑ Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39".

Further reading

External links



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