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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''DCN1-like protein 1''' is a [[protein]] that in humans is encoded by the ''DCUN1D1'' [[gene]].<ref name="pmid10777668">{{cite journal | vauthors = Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M | title = Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16 | journal = Genomics | volume = 65 | issue = 1 | pages = 70–4 | date = Apr 2000 | pmid = 10777668 | pmc =  | doi = 10.1006/geno.2000.6126 }}</ref><ref name="pmid15988528">{{cite journal | vauthors = Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M | title = The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae | journal = Nature | volume = 435 | issue = 7046 | pages = 1257–61 | date = Jun 2005 | pmid = 15988528 | pmc = | doi = 10.1038/nature03662 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54165| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.<ref>{{cite journal | vauthors = Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B | title = SCCRO promotes glioma formation and malignant progression in mice | journal = Neoplasia | volume = 12 | issue = 6 | pages = 476–84 | date = Jun 2010 | pmid = 20563250 | pmc = 2887088 | doi=10.1593/neo.10202}}</ref><ref>{{cite journal | vauthors = Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B | title = Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas | journal = Cancer Research | volume = 66 | issue = 19 | pages = 9437–44 | date = Oct 2006 | pmid = 17018598 | doi = 10.1158/0008-5472.CAN-06-2074 }}</ref><ref>{{cite journal | vauthors = Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H | title = Identification of druggable cancer driver genes amplified across TCGA datasets | journal = PLOS ONE | volume = 9 | issue = 5 | pages = e98293 | date = 2014 | pmid = 24874471 | pmc = 4038530 | doi = 10.1371/journal.pone.0098293 }}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
| HGNCid = 18184
| Symbol = DCUN1D1
| AltSymbols =; DCUN1L1; RP42; SCRO; Tes3
| OMIM = 605905
| ECnumber =
| Homologene = 10773
| MGIid = 2150386
| GeneAtlas_image1 = PBB_GE_DCUN1D1_218583_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54165
    | Hs_Ensembl = ENSG00000043093
    | Hs_RefseqProtein = NP_065691
    | Hs_RefseqmRNA = NM_020640
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 184143269
    | Hs_GenLoc_end = 184186414
    | Hs_Uniprot = Q96GG9
    | Mm_EntrezGene = 114893
    | Mm_Ensembl = ENSMUSG00000027708
    | Mm_RefseqmRNA = XM_987015
    | Mm_RefseqProtein = XP_992109
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 36084201
    | Mm_GenLoc_end = 36124353
    | Mm_Uniprot = Q3TMV8
  }}
}}
'''DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)''', also known as '''DCUN1D1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54165| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
DCUN1D1 has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[CAND1]],<ref name = pmid18826954>{{cite journal | vauthors = Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B | title = SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation | journal = The Journal of Biological Chemistry | volume = 283 | issue = 48 | pages = 33211–20 | date = Nov 2008 | pmid = 18826954 | pmc = 2586271 | doi = 10.1074/jbc.M804440200 }}</ref>
==Further reading==
* [[CUL1]],<ref name = pmid18826954/>
* [[CUL2]],<ref name = pmid18826954/>
* [[CUL3]]<ref name = pmid18826954/> and
* [[RBX1]].<ref name = pmid18826954/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B | title = SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma | journal = The Annals of Thoracic Surgery | volume = 78 | issue = 5 | pages = 1734–41 | date = Nov 2004 | pmid = 15511464 | doi = 10.1016/j.athoracsur.2004.05.056 }}
| citations =
* {{cite journal | vauthors = Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B | title = The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue | journal = Clinical Cancer Research | volume = 9 | issue = 6 | pages = 2300–6 | date = Jun 2003 | pmid = 12796399 | doi =  }}
*{{cite journal | author=Sarkaria IS, Pham D, Ghossein RA, ''et al.'' |title=SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. |journal=Ann. Thorac. Surg. |volume=78 |issue= 5 |pages= 1734-41 |year= 2005 |pmid= 15511464 |doi= 10.1016/j.athoracsur.2004.05.056 }}
* {{cite journal | vauthors = Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B | title = Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A | journal = Annals of Surgical Oncology | volume = 11 | issue = 5 | pages = 530–4 | date = May 2004 | pmid = 15123463 | doi = 10.1245/ASO.2004.03.014 }}
*{{cite journal | author=Mas C, Bourgeois F, Bulfone A, ''et al.'' |title=Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16. |journal=Genomics |volume=65 |issue= 1 |pages= 70-4 |year= 2000 |pmid= 10777668 |doi= 10.1006/geno.2000.6126 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P | title = Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 4 | pages = 2314–20 | date = Apr 2005 | pmid = 15623817 | doi = 10.1210/jc.2004-1337 }}
*{{cite journal  | author=Estilo CL, O-Charoenrat P, Ngai I, ''et al.'' |title=The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. |journal=Clin. Cancer Res. |volume=9 |issue= 6 |pages= 2300-6 |year= 2004 |pmid= 12796399 |doi=  }}
* {{cite journal | vauthors = Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B | title = Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas | journal = Surgery | volume = 136 | issue = 6 | pages = 1122–8 | date = Dec 2004 | pmid = 15657565 | doi = 10.1016/j.surg.2004.06.041 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Talbot SG, O-charoenrat P, Sarkaria IS, ''et al.'' |title=Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A. |journal=Ann. Surg. Oncol. |volume=11 |issue= 5 |pages= 530-4 |year= 2004 |pmid= 15123463 |doi= 10.1245/ASO.2004.03.014 }}
* {{cite journal | vauthors = Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B | title = Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas | journal = Cancer Research | volume = 66 | issue = 19 | pages = 9437–44 | date = Oct 2006 | pmid = 17018598 | doi = 10.1158/0008-5472.CAN-06-2074 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Jacques C, Baris O, Prunier-Mirebeau D, ''et al.'' |title=Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 4 |pages= 2314-20 |year= 2005 |pmid= 15623817 |doi= 10.1210/jc.2004-1337 }}
*{{cite journal | author=Sarkaria IS, Stojadinovic A, Talbot SG, ''et al.'' |title=Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. |journal=Surgery |volume=136 |issue= 6 |pages= 1122-8 |year= 2005 |pmid= 15657565 |doi= 10.1016/j.surg.2004.06.041 }}
*{{cite journal | author=Kurz T, Ozlü N, Rudolf F, ''et al.'' |title=The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. |journal=Nature |volume=435 |issue= 7046 |pages= 1257-61 |year= 2005 |pmid= 15988528 |doi= 10.1038/nature03662 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Sarkaria I, O-charoenrat P, Talbot SG, ''et al.'' |title=Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. |journal=Cancer Res. |volume=66 |issue= 19 |pages= 9437-44 |year= 2007 |pmid= 17018598 |doi= 10.1158/0008-5472.CAN-06-2074 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-3-stub}}

Latest revision as of 03:18, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.[1][2][3]

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.[4][5][6]

Interactions

DCUN1D1 has been shown to interact with:

References

  1. Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics. 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668.
  2. Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. doi:10.1038/nature03662. PMID 15988528.
  3. "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".
  4. Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia. 12 (6): 476–84. doi:10.1593/neo.10202. PMC 2887088. PMID 20563250.
  5. Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.
  6. Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5): e98293. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
  7. 7.0 7.1 7.2 7.3 7.4 Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

Further reading

  • Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B (Nov 2004). "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma". The Annals of Thoracic Surgery. 78 (5): 1734–41. doi:10.1016/j.athoracsur.2004.05.056. PMID 15511464.
  • Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B (Jun 2003). "The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue". Clinical Cancer Research. 9 (6): 2300–6. PMID 12796399.
  • Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B (May 2004). "Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A". Annals of Surgical Oncology. 11 (5): 530–4. doi:10.1245/ASO.2004.03.014. PMID 15123463.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P (Apr 2005). "Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors". The Journal of Clinical Endocrinology and Metabolism. 90 (4): 2314–20. doi:10.1210/jc.2004-1337. PMID 15623817.
  • Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B (Dec 2004). "Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas". Surgery. 136 (6): 1122–8. doi:10.1016/j.surg.2004.06.041. PMID 15657565.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.