DCTN3: Difference between revisions
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'''Dynactin subunit 3''' is a [[protein]] that in humans is encoded by the ''DCTN3'' [[gene]].<ref name="pmid9722614">{{cite journal | vauthors = Karki S, LaMonte B, Holzbaur EL | title = Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells | journal = J Cell Biol | volume = 142 | issue = 4 | pages = 1023–34 |date=Sep 1998 | pmid = 9722614 | pmc = 2132867 | doi =10.1083/jcb.142.4.1023 }}</ref><ref name="pmid11306820">{{cite journal | vauthors = Mills DR, Jackson CL | title = Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 92 | issue = | '''Dynactin subunit 3''' is a [[protein]] that in humans is encoded by the ''DCTN3'' [[gene]].<ref name="pmid9722614">{{cite journal | vauthors = Karki S, LaMonte B, Holzbaur EL | title = Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells | journal = J Cell Biol | volume = 142 | issue = 4 | pages = 1023–34 |date=Sep 1998 | pmid = 9722614 | pmc = 2132867 | doi =10.1083/jcb.142.4.1023 }}</ref><ref name="pmid11306820">{{cite journal | vauthors = Mills DR, Jackson CL | title = Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 92 | issue = 1–2 | pages = 166 |date=Apr 2001 | pmid = 11306820 | pmc = | doi =10.1159/000056892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCTN3 dynactin 3 (p22)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11258| accessdate = }}</ref> | ||
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Latest revision as of 07:39, 10 January 2019
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Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.[1][2][3]
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.[3]
References
- ↑ Karki S, LaMonte B, Holzbaur EL (Sep 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". J Cell Biol. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC 2132867. PMID 9722614.
- ↑ Mills DR, Jackson CL (Apr 2001). "Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 166. doi:10.1159/000056892. PMID 11306820.
- ↑ 3.0 3.1 "Entrez Gene: DCTN3 dynactin 3 (p22)".
Further reading
- Karki S, Tokito MK, Holzbaur EL (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". J. Biol. Chem. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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