DAPP1: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide''' is a [[protein]] that in humans is encoded by the '''''DAPP1''''' [[gene]].<ref name="pmid10432293">{{cite journal | vauthors = Dowler S, Currie RA, Downes CP, Alessi DR | title = DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides | journal = Biochem J | volume = 342 | issue =  1| pages = 7–12 |date=Oct 1999 | pmid = 10432293 | pmc = 1220429 | doi = 10.1042/0264-6021:3420007}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27071| accessdate = }}</ref>
| image = PBB_Protein_DAPP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fao.
| PDB = {{PDB2|1fao}}, {{PDB2|1fb8}}
| Name = Dual adaptor of phosphotyrosine and 3-phosphoinositides
| HGNCid = 16500
| Symbol = DAPP1
| AltSymbols =; BAM32; DKFZp667E0716
  | OMIM = 605768
| ECnumber =
| Homologene = 32138
| MGIid = 1347063
| GeneAtlas_image1 = PBB_GE_DAPP1_219290_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0035014 |text = phosphoinositide 3-kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27071
    | Hs_Ensembl = ENSG00000070190
    | Hs_RefseqProtein = NP_055210
    | Hs_RefseqmRNA = NM_014395
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 100957013
    | Hs_GenLoc_end = 101010334
    | Hs_Uniprot = Q9UN19
    | Mm_EntrezGene = 26377
    | Mm_Ensembl = ENSMUSG00000028159
    | Mm_RefseqmRNA = NM_011932
    | Mm_RefseqProtein = NP_036062
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 137868992
    | Mm_GenLoc_end = 137918932
    | Mm_Uniprot = Q3UK44
  }}
}}
'''Dual adaptor of phosphotyrosine and 3-phosphoinositides''', also known as '''DAPP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27071| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Dowler S, Currie RA, Downes CP, Alessi DR |title=DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. |journal=Biochem. J. |volume=342 ( Pt 1) |issue=  |pages= 7-12 |year= 1999 |pmid= 10432293 |doi= }}
*{{cite journal  | vauthors=Marshall AJ, Niiro H, Lerner CG |title=A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. |journal=J. Exp. Med. |volume=191 |issue= 8 |pages= 1319–32 |year= 2000 |pmid= 10770799 |doi=10.1084/jem.191.8.1319  | pmc=2193139 |display-authors=etal}}
*{{cite journal  | author=Marshall AJ, Niiro H, Lerner CG, ''et al.'' |title=A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. |journal=J. Exp. Med. |volume=191 |issue= 8 |pages= 1319-32 |year= 2000 |pmid= 10770799 |doi=  }}
*{{cite journal  | vauthors=Dowler S, Montalvo L, Cantrell D |title=Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 605–10 |year= 2001 |pmid= 10880360 |doi=10.1042/0264-6021:3490605 | pmc=1221184  |display-authors=etal}}
*{{cite journal  | author=Dowler S, Montalvo L, Cantrell D, ''et al.'' |title=Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 605-10 |year= 2001 |pmid= 10880360 |doi=  }}
*{{cite journal  | vauthors=Ferguson KM, Kavran JM, Sankaran VG |title=Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 373–84 |year= 2000 |pmid= 10983984 |doi=10.1016/S1097-2765(00)00037-X |display-authors=etal}}
*{{cite journal  | author=Ferguson KM, Kavran JM, Sankaran VG, ''et al.'' |title=Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 373-84 |year= 2000 |pmid= 10983984 |doi=  }}
*{{cite journal  | vauthors=Dowler S, Currie  RA, Campbell  DG |title=Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. |journal=Biochem. J. |volume=351 |issue= Pt 1 |pages= 19–31 |year= 2001 |pmid= 11001876 |doi=10.1042/0264-6021:3510019 | pmc=1221362  |display-authors=etal}}
*{{cite journal  | author=Dowler S, Currie  RA, Campbell  DG, ''et al.'' |title=Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. |journal=Biochem. J. |volume=351 |issue= Pt 1 |pages= 19-31 |year= 2001 |pmid= 11001876 |doi=  }}
*{{cite journal  | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 |display-authors=etal}}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal  | vauthors=Stephens LR, Anderson KE, Hawkins PT |title=Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42767–73 |year= 2001 |pmid= 11524430 |doi= 10.1074/jbc.M107194200 }}
*{{cite journal  | author=Stephens LR, Anderson KE, Hawkins PT |title=Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42767-73 |year= 2001 |pmid= 11524430 |doi= 10.1074/jbc.M107194200 }}
*{{cite journal  | vauthors=Niiro H, Maeda A, Kurosaki T, Clark EA |title=The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. |journal=J. Exp. Med. |volume=195 |issue= 1 |pages= 143–9 |year= 2002 |pmid= 11781373 |doi=10.1084/jem.20011524  | pmc=2196019 }}
*{{cite journal  | author=Niiro H, Maeda A, Kurosaki T, Clark EA |title=The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. |journal=J. Exp. Med. |volume=195 |issue= 1 |pages= 143-9 |year= 2002 |pmid= 11781373 |doi=  }}
*{{cite journal  | vauthors=Marshall AJ, Krahn AK, Ma K |title=TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5479–91 |year= 2002 |pmid= 12101241 |doi=10.1128/MCB.22.15.5479-5491.2002  | pmc=133950 |display-authors=etal}}
*{{cite journal  | author=Marshall AJ, Krahn AK, Ma K, ''et al.'' |title=TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5479-91 |year= 2002 |pmid= 12101241 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Han A, Saijo K, Mecklenbräuker I |title=Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. |journal=Immunity |volume=19 |issue= 4 |pages= 621–32 |year= 2003 |pmid= 14563325 |doi=10.1016/S1074-7613(03)00275-9 |display-authors=etal}}
*{{cite journal  | author=Han A, Saijo K, Mecklenbräuker I, ''et al.'' |title=Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. |journal=Immunity |volume=19 |issue= 4 |pages= 621-32 |year= 2003 |pmid= 14563325 |doi=  }}
*{{cite journal  | vauthors=Allam A, Niiro H, Clark EA, Marshall AJ |title=The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39775–82 |year= 2004 |pmid= 15247305 |doi= 10.1074/jbc.M403367200 }}
*{{cite journal  | author=Allam A, Niiro H, Clark EA, Marshall AJ |title=The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39775-82 |year= 2004 |pmid= 15247305 |doi= 10.1074/jbc.M403367200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Niiro H, Allam A, Stoddart A |title=The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. |journal=J. Immunol. |volume=173 |issue= 9 |pages= 5601–9 |year= 2004 |pmid= 15494510 |doi=  10.4049/jimmunol.173.9.5601|display-authors=etal}}
*{{cite journal  | author=Niiro H, Allam A, Stoddart A, ''et al.'' |title=The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. |journal=J. Immunol. |volume=173 |issue= 9 |pages= 5601-9 |year= 2004 |pmid= 15494510 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=27071}}
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Latest revision as of 12:06, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.[1][2]


References

  1. ↑ Dowler S, Currie RA, Downes CP, Alessi DR (Oct 1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides". Biochem J. 342 (1): 7–12. doi:10.1042/0264-6021:3420007. PMC 1220429. PMID 10432293.
  2. ↑ "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides".

Further reading



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