Cystic fibrosis CT
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Computed tomography (CT scan) findings in patients with cystic fibrosis are more sensitive as compared to the pulmonary function tests. Most common chest CT scan findings include peribronchial thickening, mucous plugging and bronchiectasis. Less common findings include abscesses, emphysematous bullae, hyperinflation, collapse, consolidation, ground-glass opacities, acinar nodules, and thickening of interlobular and intralobular septa.Findings on abdominal CT scan in patients with cystic fibrosis may include diffuse and complete fatty replacement of pancreas, fibrosis of the pancreas, and Intestinal obstruction.
CT scan
Computed tomography (CT scan) findings in patients with cystic fibrosis are more sensitive as compared to the pulmonary function tests. It has a crucial role in the assessment of pulmonary damage over time, detecting complications and monitoring treatment.[1]
Chest
- Mosaic attenuation (localized hyperinflation due to small airway obstruction) on expiratory chest computed tomography (CT) is common in early life cystic fibrosis and often referred to as "air trapping".[2]
Most common findings
Most common chest CT scan findings include:[1][3]
- Peribronchial thickening (85%)
- Mucous plugging (79%)
- Bronchiectasis which is progressive, irreversible (76%)
Less common findings
Less common chest CT scan findings include:[1][3]
- Abscesses
- Emphysematous bullae
- Hyperinflation
- Collapse
- Consolidation
- Ground-glass opacities
- Acinar nodules
- Thickening of interlobular and intralobular septa
Abdomen
Abdomen CT scan in patients with cystic fibrosis may include these findings:[4][5]
- Diffuse and complete fatty replacement of pancreas is the most common imaging appearance.
- Fibrosis of the pancreas can be detectable on CT scan.
- Intestinal findings on CT may include obstruction (more common in children).
Images
CT demonstrates mucous plugging and complete pancreatic atrophy[6]
References
- ↑ 1.0 1.1 1.2 Rybacka A, Karmelita-Katulska K (2016). "The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis". Pol J Radiol. 81: 141–5. doi:10.12659/PJR.896051. PMC 4821342. PMID 27103945.
- ↑ Rosenow T, Ramsey K, Turkovic L, Murray CP, Mok LC, Hall GL, Stick SM (September 2017). "Air trapping in early cystic fibrosis lung disease-Does CT tell the full story?". Pediatr. Pulmonol. 52 (9): 1150–1156. doi:10.1002/ppul.23754. PMID 28682006.
- ↑ 3.0 3.1 Aziz ZA, Davies JC, Alton EW, Wells AU, Geddes DM, Hansell DM (February 2007). "Computed tomography and cystic fibrosis: promises and problems". Thorax. 62 (2): 181–6. doi:10.1136/thx.2005.054379. PMC 2111250. PMID 17287306.
- ↑ Carucci LR, Jacobs JE (2003). "Focal fatty sparing of the pancreatic head in cystic fibrosis: CT findings". Abdom Imaging. 28 (6): 853–5. PMID 14753605.
- ↑ Lugo-Olivieri CH, Soyer PA, Fishman EK (1998). "Cystic fibrosis: spectrum of thoracic and abdominal CT findings in the adult patient". Clin Imaging. 22 (5): 346–54. PMID 9755398.
- ↑ "Cystic fibrosis | Radiology Case | Radiopaedia.org".