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===Symptoms===
===Symptoms===
Symptoms of cyclothymia include:<ref name=”#2”>U.S. National Library of Medicine. “Cyclothymic disorder.” https://medlineplus.gov/ency/article/001550.htm. Accessed 12 December 2016.</ref>
*Periods of both mania (extreme mood elevation and energy) and depression (low mood and energy level) for at least two years, or one in children and young adults
*Mood swings that are not as severe as those observed in bipolar disorder
*Continuity of manic/depressive episodes (i.e., no more than 2 consecutive months without symptoms)


===Physical Examination===
===Physical Examination===

Revision as of 15:14, 12 December 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2], Haleigh Williams, B.S.

Synonyms and keywords: Cyclothymic disorder; cyclic disorder

Overview

Cyclothymia, or cyclothymic disorder, is a mood disorder characterized by the co-occurrence of hypomanic and depressive symptoms over a period of at least two years, or one year in children and young adults. Symptoms must not meet the diagnostic criteria for manic/depressive episodes.[1] Cyclothymia is considered a mild form of bipolar II disorder.[2]

Historical Perspective

Cyclothymia has been included in the DSM since 1980.[3]

Classification

Cyclothymia is classified as a mild form of bipolar II disorder.[2]

Pathophysiology

Commonly Comorbid Conditions

Conditions that are commonly comorbid with cyclothymia include:[4]

  • ADHD
  • Anxiety disorders

Causes

The cause of cyclothymic disorder is unknown. Genetics may play a role, as indicated by a range of twin studies involving dizygotic (fraternal) and monozygotic (identical) twins and the high likelihood that a patient with cyclothymia will have a family history of mood disorders.[2]

Differentiating Cyclothymia from other disorders

Cyclothymia must be differentiated from other disorders that present with similar symptomatology, including:[2][5]

  • Major depression
    • Patients with cyclothymia can be distinguished from patients with major depression based on an earlier age of onset and a higher likelihood of having a family history of bipolar disorder.[6]
  • Bipolar disorder

Epidemiology and Demographics

The prevalence of cyclothymic disorder is 400-1,000 per 100,000 (0.4%-1%) of the overall population.[7][5]

Age

Gender

  • Men and women are equally likely to be affected by cyclothymia, though women may be more likely to seek treatment.[2][7]

Race

Risk Factors

Risk factors for the development of cyclothymia include:[2][5]

  • Being an adolescent
  • Genetic predisposition

Screening

Natural History, Complications, and Prognosis

  • Cyclothymia usually manifests early in a patient’s life.[2]
  • Possible complications include a progression to bipolar disorder, though this occurs in less than half of cyclothymic patients.[2]
    • Early intervention may allow patients to circumvent some of the complications associated with bipolar disorder.[4]
  • Cyclothymia may remain a chronic condition or disappear over the course of a patient’s life.[2]

Diagnosis

Diagnostic Criteria

DSM-V Diagnostic Criteria for Cyclothymic Disorder[5]

  • A. For at least 2 years (at least 1 year in children and adolescents) there have been numerous periods with hypomanic symptoms that do not meet criteria for a hypomanic

episode and numerous periods with depressive symptoms that do not meet criteria for a major depressive episode.

AND

  • B. During the above 2-year period (1 year in children and adolescents), the hypomanic and depressive periods have been present for at least half the time and the individual

has not been without the symptoms for more than 2 months at a time.

AND

  • C. Criteria for a major depressive, manic, or hypomanic episode have never been met.

AND

D. The symptoms in criterion A are not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other specified or unspecified schizophrenia spectrum and other psychotic disorder.

AND

E. The symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition (e.g., hyperthyroidism).

AND

F. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.


Specify if:

  • With anxious distress

Symptoms

Symptoms of cyclothymia include:[2]

  • Periods of both mania (extreme mood elevation and energy) and depression (low mood and energy level) for at least two years, or one in children and young adults
  • Mood swings that are not as severe as those observed in bipolar disorder
  • Continuity of manic/depressive episodes (i.e., no more than 2 consecutive months without symptoms)

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Treatment for cyclothymia can include a variety of cognitive behavioral therapy techniques. Additionally, mood stabilizers, such as lithium and medications for anxiety and mood stabilization such as benzodiazepines, are often prescribed in low doses to treat cyclothymia.

References

  1. National Institute of Mental Health (NIMH). “Bipolar Disorder.” https://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml. Accessed 12 December 2016.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 U.S. National Library of Medicine. “Cyclothymic disorder.” https://medlineplus.gov/ency/article/001550.htm. Accessed 12 December 2016.
  3. Van Meter AR, Youngstrom EA, Findling RL (2012). "Cyclothymic disorder: a critical review". Clin Psychol Rev. 32 (4): 229–43. doi:10.1016/j.cpr.2012.02.001. PMID 22459786.
  4. 4.0 4.1 Van Meter A, Youngstrom EA, Youngstrom JK, Feeny NC, Findling RL (2011). "Examining the validity of cyclothymic disorder in a youth sample". J Affect Disord. 132 (1–2): 55–63. doi:10.1016/j.jad.2011.02.004. PMC 3109127. PMID 21396717.
  5. 5.0 5.1 5.2 5.3 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing, 2013.
  6. Maina G, Salvi V, Rosso G, Bogetto F (2010). "Cyclothymic temperament and major depressive disorder: a study on Italian patients". J Affect Disord. 121 (3): 199–203. doi:10.1016/j.jad.2009.05.031. PMID 19556009.
  7. 7.0 7.1 Baldessarini RJ, Vázquez G, Tondo L (2011). "Treatment of cyclothymic disorder: commentary". Psychother Psychosom. 80 (3): 131–5. doi:10.1159/000322234. PMID 21372620.

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