Cyclosporiasis natural history, complications and prognosis: Difference between revisions

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==Natural History==
==Natural History==
Following inoculation of ''[[C. cayetanensis]], the typical incubation period is  about 7 days<ref name="pmid9605784">{{cite journal| author=Fleming CA, Caron D, Gunn JE, Barry MA| title=A foodborne outbreak of Cyclospora cayetanensis at a wedding: clinical features and risk factors for illness. | journal=Arch Intern Med | year= 1998 | volume= 158 | issue= 10 | pages= 1121-5 | pmid=9605784 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9605784  }} </ref><ref name="pmid9164810">{{cite journal| author=Herwaldt BL, Ackers ML| title=An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group. | journal=N Engl J Med | year= 1997 | volume= 336 | issue= 22 | pages= 1548-56 | pmid=9164810 | doi=10.1056/NEJM199705293362202 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9164810  }} </ref>  
Following ingestion of sporulated [[oocysts]] of ''[[C. cayetanensis]]'', the typical incubation period is  about 7 days.<ref name="pmid9605784">{{cite journal| author=Fleming CA, Caron D, Gunn JE, Barry MA| title=A foodborne outbreak of Cyclospora cayetanensis at a wedding: clinical features and risk factors for illness. | journal=Arch Intern Med | year= 1998 | volume= 158 | issue= 10 | pages= 1121-5 | pmid=9605784 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9605784  }} </ref><ref name="pmid9164810">{{cite journal| author=Herwaldt BL, Ackers ML| title=An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group. | journal=N Engl J Med | year= 1997 | volume= 336 | issue= 22 | pages= 1548-56 | pmid=9164810 | doi=10.1056/NEJM199705293362202 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9164810  }} </ref>  Cyclosporiasis commonly presents with the following symptoms:<ref name="pmid10451156">{{cite journal| author=Connor BA, Reidy J, Soave R| title=Cyclosporiasis: clinical and histopathologic correlates. | journal=Clin Infect Dis | year= 1999 | volume= 28 | issue= 6 | pages= 1216-22 | pmid=10451156 | doi=10.1086/514780 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10451156  }} </ref><ref name="pmid9605784">{{cite journal| author=Fleming CA, Caron D, Gunn JE, Barry MA| title=A foodborne outbreak of Cyclospora cayetanensis at a wedding: clinical features and risk factors for illness. | journal=Arch Intern Med | year= 1998 | volume= 158 | issue= 10 | pages= 1121-5 | pmid=9605784 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9605784  }} </ref><ref name="pmid9164810">{{cite journal| author=Herwaldt BL, Ackers ML| title=An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group. | journal=N Engl J Med | year= 1997 | volume= 336 | issue= 22 | pages= 1548-56 | pmid=9164810 | doi=10.1056/NEJM199705293362202 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9164810  }} </ref><ref name="pmid9395371">{{cite journal| author=Ortega YR, Nagle R, Gilman RH, Watanabe J, Miyagui J, Quispe H et al.| title=Pathologic and clinical findings in patients with cyclosporiasis and a description of intracellular parasite life-cycle stages. | journal=J Infect Dis | year= 1997 | volume= 176 | issue= 6 | pages= 1584-9 | pmid=9395371 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9395371  }} </ref><ref name="pmid1928575">{{cite journal| author=Shlim DR, Cohen MT, Eaton M, Rajah R, Long EG, Ungar BL| title=An alga-like organism associated with an outbreak of prolonged diarrhea among foreigners in Nepal. | journal=Am J Trop Med Hyg | year= 1991 | volume= 45 | issue= 3 | pages= 383-9 | pmid=1928575 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1928575  }} </ref>
*[[Anorexia]]
 
*[[Nausea]]
 
*[[Flatulence]]
 
*[[Fatigue]]
 
*[[Abdominal cramping]]
 
*[[Diarrhea]]
 
*Low-grade [[fever]]
 
*[[Weight loss]]


* Symptoms of cyclosporiasis begin an average of 7 days (range, 2 days to > 2 weeks) after ingestion of sporulated [[oocysts]] (the infective form of the parasite).
* If a person ill with cyclosporiasis is not treated, symptoms can persist for several weeks to a month or more. Some symptoms, such as [[diarrhea]], can return, and some symptoms, such as [[muscle aches]] and [[fatigue]], may continue after the gastrointestinal symptoms have gone away.
* If a person ill with cyclosporiasis is not treated, symptoms can persist for several weeks to a month or more. Some symptoms, such as [[diarrhea]], can return, and some symptoms, such as [[muscle aches]] and [[fatigue]], may continue after the gastrointestinal symptoms have gone away.
* Infection is not usually life-threatening.
* Infection is not usually life-threatening.
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Cyclospora infection is characterized by anorexia, nausea, flat- ulence, fatigue, abdominal cramping, diarrhea (however, the average duration of diarrhea for HIV-positive patients is longer than that for HIV-negative patients (199 days and 57.2 days, respectively) (163, 172)), low-grade fever, and weight loss (42, 68, 83, 140, 171).


The clinical presentation is somewhat different in areas of endemicity, where asymptomatic infections are more frequent.  
The clinical presentation is somewhat different in areas of endemicity, where asymptomatic infections are more frequent.  

Revision as of 20:32, 18 September 2014

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Overview

The symptoms usually start within one week of ingestion of contaminated food and water. If left untreated, symptoms may persist for weeks and months. This infection is not life threatening and is rarely associated with complications. People living in endemic area might have asymptomatic infections.

Natural History

Following ingestion of sporulated oocysts of C. cayetanensis, the typical incubation period is about 7 days.[1][2] Cyclosporiasis commonly presents with the following symptoms:[3][1][2][4][5]

  • If a person ill with cyclosporiasis is not treated, symptoms can persist for several weeks to a month or more. Some symptoms, such as diarrhea, can return, and some symptoms, such as muscle aches and fatigue, may continue after the gastrointestinal symptoms have gone away.
  • Infection is not usually life-threatening.
  • Reported complications from Cyclospora infection are rare, but have included malabsorption and cholecystitis.
  • Some people with Cyclospora infection experience no symptoms at all, particularly persons living in areas where the disease is endemic.


Complications

Prognosis

References

  1. 1.0 1.1 Fleming CA, Caron D, Gunn JE, Barry MA (1998). "A foodborne outbreak of Cyclospora cayetanensis at a wedding: clinical features and risk factors for illness". Arch Intern Med. 158 (10): 1121–5. PMID 9605784.
  2. 2.0 2.1 Herwaldt BL, Ackers ML (1997). "An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group". N Engl J Med. 336 (22): 1548–56. doi:10.1056/NEJM199705293362202. PMID 9164810.
  3. Connor BA, Reidy J, Soave R (1999). "Cyclosporiasis: clinical and histopathologic correlates". Clin Infect Dis. 28 (6): 1216–22. doi:10.1086/514780. PMID 10451156.
  4. Ortega YR, Nagle R, Gilman RH, Watanabe J, Miyagui J, Quispe H; et al. (1997). "Pathologic and clinical findings in patients with cyclosporiasis and a description of intracellular parasite life-cycle stages". J Infect Dis. 176 (6): 1584–9. PMID 9395371.
  5. Shlim DR, Cohen MT, Eaton M, Rajah R, Long EG, Ungar BL (1991). "An alga-like organism associated with an outbreak of prolonged diarrhea among foreigners in Nepal". Am J Trop Med Hyg. 45 (3): 383–9. PMID 1928575.

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