Cushing's syndrome natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Cushing's disease can lead to diabetes, cardiovascular and psychiatric complications.
Complications
- Insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus.
- Cushing's syndrome can lead to myocardial infarction, left ventricular dysfunction, and cerebrovascular disease.
- Cushing’s syndrome creates a hypercoagulable state due to an activated coagulation cascade and impaired fibrinolysis.
- Major depression
- Anxiety disorders
- Opportunistic infections
- Sepsis
Prognosis
The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of tumors may recur. Mortality in the patients with Cushing's syndrome is increased even after the apparently successful treatment.[1]
References
- ↑ Lodish M (2015). "Cushing's syndrome in childhood: update on genetics, treatment, and outcomes". Curr Opin Endocrinol Diabetes Obes. 22 (1): 48–54. doi:10.1097/MED.0000000000000127. PMC 4415092. PMID 25517021.