Cushing's syndrome natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Cushing's disease can lead to [[Diabetes mellitus|diabetes]], cardiovascular and psychiatric complications. The prognosis depends on the severity of the disease. | Cushing's disease can lead to [[Diabetes mellitus|diabetes]], [[cardiovascular]] and [[Psychiatric|psychiatric complications]]. The prognosis depends on the severity of the disease. | ||
==Complications== | ==Complications== | ||
Cushing's syndrome can lead to the following complications:<ref name="pmid26004339">{{cite journal |vauthors=Lacroix A, Feelders RA, Stratakis CA, Nieman LK |title=Cushing's syndrome |journal=Lancet |volume=386 |issue=9996 |pages=913–27 |year=2015 |pmid=26004339 |doi=10.1016/S0140-6736(14)61375-1 |url=}}</ref> | Cushing's syndrome can lead to the following complications:<ref name="pmid26004339">{{cite journal |vauthors=Lacroix A, Feelders RA, Stratakis CA, Nieman LK |title=Cushing's syndrome |journal=Lancet |volume=386 |issue=9996 |pages=913–27 |year=2015 |pmid=26004339 |doi=10.1016/S0140-6736(14)61375-1 |url=}}</ref> | ||
* [[Insulin resistance]] (especially common in [[ectopic]] | * [[Insulin resistance]] (especially common in [[Ectopic ACTH Syndrome|ectopic ACTH production]]), leading to [[hyperglycemia]] (high [[blood sugar]]s) which can lead to [[diabetes mellitus]]. | ||
* Cushing's syndrome can lead to [[myocardial infarction]], [[left ventricular dysfunction]], and cerebrovascular disease. | * Cushing's syndrome can lead to [[myocardial infarction]], [[left ventricular dysfunction]], and [[cerebrovascular disease]]. | ||
*Cushing’s syndrome creates a [[hypercoagulable state]] due to an activated coagulation cascade and impaired [[fibrinolysis]]. | *Cushing’s syndrome creates a [[hypercoagulable state]] due to an activated [[coagulation cascade]] and impaired [[fibrinolysis]]. | ||
*[[Major depression]] | *[[Major depression]] | ||
*[[Anxiety disorder|Anxiety disorders]] | *[[Anxiety disorder|Anxiety disorders]] | ||
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==Prognosis== | ==Prognosis== | ||
The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of [[tumor]]s may recur. Mortality in the patients with Cushing's syndrome is increased even after the apparently successful treatment.<ref name="pmid25517021">{{cite journal |vauthors=Lodish M |title=Cushing's syndrome in childhood: update on genetics, treatment, and outcomes |journal=Curr Opin Endocrinol Diabetes Obes |volume=22 |issue=1 |pages=48–54 |year=2015 |pmid=25517021 |pmc=4415092 |doi=10.1097/MED.0000000000000127 |url=}}</ref> | The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of [[tumor]]s may recur. [[Mortality]] in the patients with Cushing's syndrome is increased even after the apparently successful treatment.<ref name="pmid25517021">{{cite journal |vauthors=Lodish M |title=Cushing's syndrome in childhood: update on genetics, treatment, and outcomes |journal=Curr Opin Endocrinol Diabetes Obes |volume=22 |issue=1 |pages=48–54 |year=2015 |pmid=25517021 |pmc=4415092 |doi=10.1097/MED.0000000000000127 |url=}}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Cushing's disease can lead to diabetes, cardiovascular and psychiatric complications. The prognosis depends on the severity of the disease.
Complications
Cushing's syndrome can lead to the following complications:[1]
- Insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus.
- Cushing's syndrome can lead to myocardial infarction, left ventricular dysfunction, and cerebrovascular disease.
- Cushing’s syndrome creates a hypercoagulable state due to an activated coagulation cascade and impaired fibrinolysis.
- Major depression
- Anxiety disorders
- Opportunistic infections
- Sepsis
Prognosis
The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of tumors may recur. Mortality in the patients with Cushing's syndrome is increased even after the apparently successful treatment.[2]
References
- ↑ Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015). "Cushing's syndrome". Lancet. 386 (9996): 913–27. doi:10.1016/S0140-6736(14)61375-1. PMID 26004339.
- ↑ Lodish M (2015). "Cushing's syndrome in childhood: update on genetics, treatment, and outcomes". Curr Opin Endocrinol Diabetes Obes. 22 (1): 48–54. doi:10.1097/MED.0000000000000127. PMC 4415092. PMID 25517021.