Cushing's syndrome differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Differentiating Cushing's syndrome from Other Diseases


Causes Suggestive findings Diagnostic approach
Skin

infections

Bacterial
  • Skin edema, erythema, and warmth.
  • Pruritus, pain, and discharge from the lesions.
  • Physical examination reveals local inflammatory findings
  • Culture/sensitivity of discharge
Candidal
  • Erythematous skin plaques and erosions with peripheral scaling.
  • Pruritus on the skin plaques.
  • KOH preparation of skin scrapings
Scabies
  • Erythematous papules with hemorrhagic crustings.
  • Pruritus, pain, and bleeding from papules.
  • Identification of eggs on skin scrapings
HPV

(Condylomata

acuminata)

  • Soft papules/plaques in the anogenital area.
  • Pruritus, pain, and bleeding from papules.
Other skin diseases Atopic dermatitis
  • Scaly, erythematous, pruritic and skin lesions.
  • Physical examination
Seborrheic dermatitis
  • Erythematous, yellow, oily plaques
  • Mild pruritus
  • Physical examination
Contact dermatitis
  • Erythematous, pruritic skin lesion
  • Physical examination
Lichen planus
Lichen sclerosus
Perianal carcinoma (Bowen disease or Paget's disease)

References


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