Congenital rubella syndrome pathophysiology: Difference between revisions

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==Overview==
==Overview==
Congenital rubella syndrome results from the spread of infection to the [[fetus]] by the mother during the viremic stage. Rubella virus enters the fetus through the [[placenta]] and causes damage to all the germ layers of the fetus.  This results in rapid death of some cells.
 


==Pathophysiology==
==Pathophysiology==
Congenital rubella syndrome results from the [[infection]] of fetus by [[transmission]] of virus from the mother during the viremic stage of the infection. Virus travels through the blood stream of the fetus and damages the blood vessels. This results in ischemic injury to the cells in the germ layers. The risk of congenital infection and defects is highest during the first 12 weeks of gestation and decreases after the 12th week of [[gestation]] with defects rare after the 20th week of gestation. If infection occurs 0–28 days before [[conception]], there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if [[rubella]] is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of [[gestation]] and continues to disseminate the virus after birth.
 


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Disease]]
 
[[Category:Pediatrics]]
[[Category:Neonatology]]
[[Category:Congenital disorders]]
[[Category:Infectious disease]]
[[Category:Syndromes]]


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Revision as of 18:21, 16 January 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

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