Congenital rubella syndrome differential diagnosis: Difference between revisions

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[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Congenital_rubella_syndrome]]
{{Congenital rubella syndrome}}
{{CMG}}; {{AE}} {{DN}}  
{{CMG}} ; {{AE}} {{ADI}}
 
==Overview==
==Overview==
[[Congenital rubella syndrome]] has to be differentiated from other congenital infections ([[TORCH complex|TORCH infections]]) as they may have some overlapping features.
The most important congenital infections, which can be transmitted vertically from mother to fetus are the [[TORCH infections]]. These infections have overlapping features and hence, must be differentiated from CRS.<ref name="pmid25677998">{{cite journal |vauthors=Neu N, Duchon J, Zachariah P |title=TORCH infections |journal=Clin Perinatol |volume=42 |issue=1 |pages=77–103, viii |year=2015 |pmid=25677998 |doi=10.1016/j.clp.2014.11.001 |url=}}</ref><ref name="pmid25654000">{{cite journal |vauthors=Ajij M, Nangia S, Dubey BS |title=Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis |journal=J Clin Diagn Res |volume=8 |issue=12 |pages=PD03–4 |year=2014 |pmid=25654000 |pmc=4316306 |doi=10.7860/JCDR/2014/10271.5293 |url=}}</ref>


==Differentiating Congenital Rubella Syndrome from other Diseases==
==Differentiating Congenital Rubella Syndrome from other Diseases==
[[Congenital rubella syndrome]] has features similar to other diseases and they need to be differentiated for  appropriate management. Differential diagnosis includes
 
* Congenital infections
The most important congenital infections, which can be transmitted vertically from mother to fetus are the [[TORCH infections]]. These infections have overlapping features and hence, must be differentiated from CRS:<ref name="pmid25677998">{{cite journal |vauthors=Neu N, Duchon J, Zachariah P |title=TORCH infections |journal=Clin Perinatol |volume=42 |issue=1 |pages=77–103, viii |year=2015 |pmid=25677998 |doi=10.1016/j.clp.2014.11.001 |url=}}</ref><ref name="pmid25654000">{{cite journal |vauthors=Ajij M, Nangia S, Dubey BS |title=Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis |journal=J Clin Diagn Res |volume=8 |issue=12 |pages=PD03–4 |year=2014 |pmid=25654000 |pmc=4316306 |doi=10.7860/JCDR/2014/10271.5293 |url=}}</ref>
** [[Toxoplasmosis]]
<SMALL>
** Congenital cytomegalovirus infection
{| class="wikitable"
** Congenital herpes simplex virus infection
!Congenital Infection
** [[Congenital syphilis]]
!Cardiac Findings
!Skin Findings
!Ocular Findings
!Hepatosplenomegaly
!Hydrocephaly
!Microcephaly
!Intracranial Calcifications
!Hearing deficits
|-
!Toxoplasmosis
|—
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|Diffuse intracranial calcifications
|—
|-
!Treponema pallidum
|—
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
* [[Glaucoma]]
|✔
|—
|—
|—
|—
|-
!Rubella
|
* [[Patent ductus arteriosus (PDA)]]
* [[Pulmonary artery stenosis]]
* [[Coarctation of the aorta]]
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
* [[Glaucoma]]
* [[Microphthalmia]]
|✔
|✔
|✔
|—
|✔
|-
!Cytomegalovirus (CMV)
|✔
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
|✔
|—
|✔
|Periventricular calcifications
|✔
|-
!Herpes simplex virus (HSV)
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
* [[Vesicles]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|—
|✔
|-
!Parvovirus B19
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Subcutaneous]] [[edema]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
|✔
|—
|—
|—
|—
|}
 
</SMALL>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


{{WH}}
{{WS}}
[[Category:Emergency medicine]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Neonatology]]
[[Category:Obstetrics]]
[[Category:Congenital disorders]]
[[Category:Infectious disease]]
[[Category:Syndromes]]
[[Category:Needs content]]
 
{{WH}}
{{WS}}

Latest revision as of 21:03, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS.[1][2]

Differentiating Congenital Rubella Syndrome from other Diseases

The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS:[1][2]

Congenital Infection Cardiac Findings Skin Findings Ocular Findings Hepatosplenomegaly Hydrocephaly Microcephaly Intracranial Calcifications Hearing deficits
Toxoplasmosis — ✔ ✔ ✔ Diffuse intracranial calcifications —
Treponema pallidum — ✔ — — — —
Rubella ✔ ✔ ✔ — ✔
Cytomegalovirus (CMV) ✔ ✔ — ✔ Periventricular calcifications ✔
Herpes simplex virus (HSV) ✔ ✔ ✔ — ✔
Parvovirus B19 ✔ — — — —

References

  1. ↑ 1.0 1.1 Neu N, Duchon J, Zachariah P (2015). "TORCH infections". Clin Perinatol. 42 (1): 77–103, viii. doi:10.1016/j.clp.2014.11.001. PMID 25677998.
  2. ↑ 2.0 2.1 Ajij M, Nangia S, Dubey BS (2014). "Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis". J Clin Diagn Res. 8 (12): PD03–4. doi:10.7860/JCDR/2014/10271.5293. PMC 4316306. PMID 25654000.

Template:WH Template:WS

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