Congenital hypothyroidism natural history, complications and prognosis

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Congenital hypothyroidism Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Natural History

Complications

Prognosis

  • Prognosis of congenital hypothyroidism depends on whether the baby starts thyroid hormone replacement therapy early.
  • The earlier the treatment begins, the better outcome the baby will be.

Most children born with congenital hypothyroidism and correctly treated with thyroxine grow and develop normally in all respects. Even most of those with athyreosis and undetectable T4 levels at birth develop with normal intelligence, although as a population academic performance tends to be below that of siblings and mild learning problems occur in some.[1]

Congenital hypothyroidism is the most common preventable cause of mental retardation. Few treatments in the practice of medicine provide as large a benefit for as small an effort.

References

  1. Moltz KC, Postellon DC (1994). "Congenital hypothyroidism and mental development". Comprehensive therapy. 20 (6): 342–6. PMID 8062543.

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