Congenital diaphragmatic hernia pathophysiology

Congenital diaphragmatic hernia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Pathophysiology

It involves three major defects.

• A failure of the diaphragm to completely close during development.
• Herniation of the abdominal contents into the chest
• Pulmonary hypoplasia or decreased lung volume is directly related to the abdominal organs presence in the chest cavity which causes the lungs to be severely undersized, especially on the side of the hernia.
• Pulmonary hypertension is a restriction of blood flow through the lungs thought to be caused by defects in the lung.