Colorectal cancer laboratory tests
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To view the laboratory findings of familial adenomatous polyposis (FAP), click here
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.
Overview
The laboratory findings associated with colorectal carcinoma are the following: CBC, FOBT, serum CEA and CA 19-9 concentration, serum iron concentrations, serum vitamin B12 and folate concentrations, liver function tests, and pulmonary function tests.
Colorectal Cancer Laboratory Findings
Laboratory findings consistent with the diagnosis of colorectal cancer include:
- Complete blood count and differential count
- anemia
- Individuals with microcytic anemia over 50 years of age are suspected of having colorectal cancer.[1]
- Fecal occult blood test(FOBT)
- Demonstrates occult bleeding from the intestines
- Serum carcino-embryogenic antigen (CEA) and CA 19-9 [2]
- Elevated concentrations associated with larger tumor masses and have a poorer prognosis
- Sensitivity of CEA in diagnosis of colorectal cancer is almost 50%[3]
References
- ↑ Zhu, Amy; Kaneshiro, Marc; Kaunitz, Jonathan D. (2010). "Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective". Digestive Diseases and Sciences. 55 (3): 548–559. doi:10.1007/s10620-009-1108-6. ISSN 0163-2116.
- ↑ Macdonald JS (1999). "Carcinoembryonic antigen screening: pros and cons". Semin Oncol. 26 (5): 556–60. PMID 10528904.
- ↑ Liu Z, Zhang Y, Niu Y, Li K, Liu X, Chen H; et al. (2014). "A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer". PLoS One. 9 (8): e103910. doi:10.1371/journal.pone.0103910. PMC 4126674. PMID 25105762.