Colorectal cancer laboratory tests: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Colon cancer}} | {{Colon cancer}} | ||
To view the laboratory findings of familial adenomatous polyposis (FAP), click [[Familial adenomatous polyposis laboratory findings|'''here''']]<br> | |||
To view the laboratory findings of hereditary nonpolyposis colorectal cancer (HNPCC), click [[Hereditary nonpolyposis colorectal cancer laboratory findings|'''here''']]<br><br> | |||
{{CMG}} {{AE}} Saarah T. Alkhairy, M.D. | |||
==Overview== | |||
The laboratory findings associated with colorectal carcinoma are the following: [[Complete blood count|CBC]], [[FOBT]], [[CEA|serum CEA]] and [[CA 19-9|CA 19-9 concentration]], [[Serum iron|serum iron concentrations]], [[Vitamin B12|serum vitamin B12]] and [[Folate|folate concentrations]], [[liver function tests]], and [[pulmonary function tests]]. | |||
== | == Colorectal Cancer Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of colorectal cancer include: | |||
=== | *[[Complete blood count]] and differential count | ||
* [[ | **[[anemia]] | ||
* [[ | **Individuals with [[microcytic anemia]] over 50 years of age are suspected of having colorectal cancer.<ref name="ZhuKaneshiro2010">{{cite journal|last1=Zhu|first1=Amy|last2=Kaneshiro|first2=Marc|last3=Kaunitz|first3=Jonathan D.|title=Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective|journal=Digestive Diseases and Sciences|volume=55|issue=3|year=2010|pages=548–559|issn=0163-2116|doi=10.1007/s10620-009-1108-6}}</ref> | ||
*[[Fecal occult blood test]]([[FOBT]]) | |||
**Demonstrates occult bleeding from the intestines | |||
*Serum [[carcino-embryogenic antigen]] ([[CEA]]) and [[CA 19-9]] <ref name="pmid10528904">{{cite journal| author=Macdonald JS| title=Carcinoembryonic antigen screening: pros and cons. | journal=Semin Oncol | year= 1999 | volume= 26 | issue= 5 | pages= 556-60 | pmid=10528904 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10528904 }}</ref> | |||
**Elevated concentrations associated with larger tumor masses and have a poorer prognosis | |||
**Sensitivity of CEA in diagnosis of colorectal cancer is almost 50%<ref name="pmid25105762">{{cite journal| author=Liu Z, Zhang Y, Niu Y, Li K, Liu X, Chen H et al.| title=A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer. | journal=PLoS One | year= 2014 | volume= 9 | issue= 8 | pages= e103910 | pmid=25105762 | doi=10.1371/journal.pone.0103910 | pmc=4126674 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25105762 }}</ref> | |||
==References== | ==References== | ||
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[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Conditions diagnosed by stool test]] | [[Category:Conditions diagnosed by stool test]] | ||
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To view the laboratory findings of familial adenomatous polyposis (FAP), click here
To view the laboratory findings of hereditary nonpolyposis colorectal cancer (HNPCC), click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.
Overview
The laboratory findings associated with colorectal carcinoma are the following: CBC, FOBT, serum CEA and CA 19-9 concentration, serum iron concentrations, serum vitamin B12 and folate concentrations, liver function tests, and pulmonary function tests.
Colorectal Cancer Laboratory Findings
Laboratory findings consistent with the diagnosis of colorectal cancer include:
- Complete blood count and differential count
- anemia
- Individuals with microcytic anemia over 50 years of age are suspected of having colorectal cancer.[1]
- Fecal occult blood test(FOBT)
- Demonstrates occult bleeding from the intestines
- Serum carcino-embryogenic antigen (CEA) and CA 19-9 [2]
- Elevated concentrations associated with larger tumor masses and have a poorer prognosis
- Sensitivity of CEA in diagnosis of colorectal cancer is almost 50%[3]
References
- ↑ Zhu, Amy; Kaneshiro, Marc; Kaunitz, Jonathan D. (2010). "Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective". Digestive Diseases and Sciences. 55 (3): 548–559. doi:10.1007/s10620-009-1108-6. ISSN 0163-2116.
- ↑ Macdonald JS (1999). "Carcinoembryonic antigen screening: pros and cons". Semin Oncol. 26 (5): 556–60. PMID 10528904.
- ↑ Liu Z, Zhang Y, Niu Y, Li K, Liu X, Chen H; et al. (2014). "A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer". PLoS One. 9 (8): e103910. doi:10.1371/journal.pone.0103910. PMC 4126674. PMID 25105762.