Cofilin 1

Cofilin 1 (non-muscle)
PDB rendering based on 1q8g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q8g​, 1q8x​
Identifiers
Symbols	CFL1 ; CFL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 39624
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cofilin 1 (non-muscle), also known as CFL1, is a human gene.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM]

Further reading

• Maciver SK, Hussey PJ (2002). "The ADF/cofilin family: actin-remodeling proteins". Genome Biol. 3 (5): reviews3007. PMID 12049672.
• Samstag Y, Nebl G (2004). "Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes". Adv. Enzyme Regul. 43: 197–211. PMID 12791392.
• Ogawa K, Tashima M, Yumoto Y; et al. (1991). "Coding sequence of human placenta cofilin cDNA". Nucleic Acids Res. 18 (23): 7169. PMID 2263493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Steege G, Draaijers TG, Grootscholten PM; et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region". Eur. J. Hum. Genet. 3 (2): 87–95. PMID 7552146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davidson MM, Haslam RJ (1994). "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+". Biochem. J. 301 ( Pt 1): 41–7. PMID 8037689.
• Ono S, Minami N, Abe H, Obinata T (1994). "Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle". J. Biol. Chem. 269 (21): 15280–6. PMID 8195165.CS1 maint: Multiple names: authors list (link)
• Abe H, Nagaoka R, Obinata T (1993). "Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes". Exp. Cell Res. 206 (1): 1–10. doi:10.1006/excr.1993.1113. PMID 8482351.CS1 maint: Multiple names: authors list (link)
• Gillett GT, Fox MF, Rowe PS; et al. (1996). "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14". Ann. Hum. Genet. 60 (Pt 3): 201–11. PMID 8800436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada K, Takano-Ohmuro H, Obinata T, Abe H (1996). "Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood". Exp. Cell Res. 227 (1): 116–22. doi:10.1006/excr.1996.0256. PMID 8806458.CS1 maint: Multiple names: authors list (link)
• Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin". J. Biol. Chem. 271 (42): 26276–80. PMID 8824278.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ott DE, Coren LV, Kane BP; et al. (1996). "Cytoskeletal proteins inside human immunodeficiency virus type 1 virions". J. Virol. 70 (11): 7734–43. PMID 8892894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang N, Higuchi O, Ohashi K; et al. (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization". Nature. 393 (6687): 809–12. doi:10.1038/31735. PMID 9655398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodal AA, Tetreault JW, Lappalainen P; et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251–64. PMID 10366597.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maekawa M, Ishizaki T, Boku S; et al. (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895–8. PMID 10436159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sumi T, Matsumoto K, Takai Y, Nakamura T (2000). "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2". J. Cell Biol. 147 (7): 1519–32. PMID 10613909.CS1 maint: Multiple names: authors list (link)
• Adachi R, Matsui S, Kinoshita M; et al. (2001). "Nitric oxide induces chemotaxis of neutrophil-like HL-60 cells and translocation of cofilin to plasma membranes". Int. J. Immunopharmacol. 22 (11): 855–64. PMID 11090694.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee K, Jung J, Kim M, Guidotti G (2001). "Interaction of the alpha subunit of Na,K-ATPase with cofilin". Biochem. J. 353 (Pt 2): 377–85. PMID 11139403.CS1 maint: Multiple names: authors list (link)
• Toshima J, Toshima JY, Amano T; et al. (2001). "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation". Mol. Biol. Cell. 12 (4): 1131–45. PMID 11294912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.CS1 maint: Multiple names: authors list (link)