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==Overview==
==Overview==
'''Clofedanol''' ([[International Nonproprietary Name|INN]]) or '''chlophedianol''' ([[British Approved Name|BAN]]) is a centrally acting [[cough medicine|cough suppressant]] used in the treatment of dry cough. Clofedanol has [[local anesthetic]] and [[antihistamine]] properties, and may have [[anticholinergic]] effects at high doses.<ref>{{cite web | url = http://www.biam2.org/www/Sub4074.html | title = Clofedanol | accessdate = 2007-04-15 | date = 1998-07-24 | publisher = BIAM|language=fr}}</ref> It is marketed in [[Canada]] under the trade name '''Ulone''', but is not available currently in the [[United States]]. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name ''Clofera''. It has a release to market date in the beginning of the fourth quarter 2009.<ref>{{cite web | url = http://www.cenrx.com/news.php | title = Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion | accessdate = 2009-09-27 | publisher = Cenrx.com}}</ref> Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process<ref>{{cite web | url = http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/ucm114742.pdf | title = Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57 | date = 1987-08-12 | publisher = FDA.gov}}</ref> and its safety and efficacy data are limited.
'''Clofedanol''' ([[International Nonproprietary Name|INN]]) or '''chlophedianol''' ([[British Approved Name|BAN]]) is a centrally acting [[cough medicine|cough suppressant]] used in the treatment of dry cough. Clofedanol has [[local anesthetic]] and [[antihistamine]] properties, and may have [[anticholinergic]] effects at high doses.<ref>{{cite web | url = http://www.biam2.org/www/Sub4074.html | title = Clofedanol | accessdate = 2007-04-15 | date = 1998-07-24 | publisher = BIAM|language=fr}}</ref> It is marketed in [[Canada]] under the trade name '''Ulone''', but is not available currently in the [[United States]]. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name ''Clofera''. It has a release to market date in the beginning of the fourth quarter 2009.<ref>{{cite web | url = http://www.cenrx.com/news.php | title = Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion | accessdate = 2009-09-27 | publisher = Cenrx.com}}</ref> Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process<ref>{{cite web | url = http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/ucm114742.pdf | title = Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57 | date = 1987-08-12 | publisher = FDA.gov}}</ref> and its safety and efficacy data are limited.
==Synthesis==
==Synthesis==
[[File:Clofedanol1.png|thumb|center|500px|Clofedanol synthesis: R. Lorenz and H. Henecka, {{US Patent|3,031,377}} (1962).]]
[[File:Clofedanol1.png|thumb|center|500px|Clofedanol synthesis: R. Lorenz and H. Henecka, {{US Patent|3,031,377}} (1962).]]
==See also==
*[[Azacyclonol]]


== References ==
== References ==

Latest revision as of 19:02, 7 April 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[3] and its safety and efficacy data are limited.

Synthesis

Clofedanol synthesis: R. Lorenz and H. Henecka, Template:US Patent (1962).

References

  1. "Clofedanol" (in français). BIAM. 1998-07-24. Retrieved 2007-04-15.
  2. "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
  3. "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.

Template:Cough and cold preparations