Cirrhosis risk factors: Difference between revisions
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{{Cirrhosis}} | {{Cirrhosis}} | ||
{{CMG}} {{AE}} {{ADI}} {{Cherry}} | |||
==Overview== | ==Overview== | ||
Lifestyle and genetic [[Risk factor|risk factors]] play an important role in the development of cirrhosis in patients. Chronic [[alcohol]] use, chronic [[hepatitis B]] and [[Hepatitis c|C]] [[infection]] and genetic diseases such as [[cystic fibrosis]] are also significant [[risk factors]] for the development of cirrhosis. | |||
==Risk Factors== | ==Risk Factors== | ||
The [[risk factors]] of cirrhosis are as follows: | |||
*Chronic [[alcohol abuse]]: | *Chronic [[alcohol abuse]]: regular moderate [[alcohol]] consumption is the most common cause of cirrhosis in the United States and other western countries<ref name="pmid9462221">{{cite journal |vauthors=Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Crocè L, Sasso F, Pozzato G, Cristianini G, Brandi G |title=Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group |journal=Gut |volume=41 |issue=6 |pages=845–50 |year=1997 |pmid=9462221 |pmc=1891602 |doi= |url=}}</ref> | ||
*Chronic Hepatitis B and C viruses | *Chronic [[Hepatitis B]] and [[Hepatitis c|C]] viruses: most common cause of cirrhosis in Asian countries | ||
*[[Autoimmune hepatitis]] | *[[Autoimmune hepatitis]] | ||
*Chronic bile duct | *Chronic blockage of the [[bile duct]] | ||
*[[Wilson's Disease]] | *[[Wilson's Disease]] | ||
*[[Cystic fibrosis]] | *[[hemochromatosis]] | ||
*Nonalcoholic fatty liver disease | *[[Cystic fibrosis]] | ||
* | *[[Alpha l-antitrypsin deficiency]] | ||
*[[Nonalcoholic fatty liver disease]] | |||
*Prolonged exposure to drugs and [[toxins]] | |||
*Age above 50 years <ref name="pmid9121257">{{cite journal |vauthors=Poynard T, Bedossa P, Opolon P |title=Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups |journal=Lancet |volume=349 |issue=9055 |pages=825–32 |year=1997 |pmid=9121257 |doi= |url=}}</ref> | |||
*Male gender <ref name="pmid10323892">{{cite journal |vauthors=Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Crocè LS, Mazzoran L, Masutti F, Cristianini G, Tiribelli C |title=Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study |journal=Gut |volume=44 |issue=6 |pages=874–80 |year=1999 |pmid=10323892 |pmc=1727553 |doi= |url=}}</ref> | |||
*Features of [[metabolic syndrome]] in [[Non-alcoholic fatty liver disease|Non Alcoholic Steato Heaptitis(NASH)]]: <ref name="pmid16540768">{{cite journal |vauthors=Clark JM |title=The epidemiology of nonalcoholic fatty liver disease in adults |journal=J. Clin. Gastroenterol. |volume=40 Suppl 1 |issue= |pages=S5–10 |year=2006 |pmid=16540768 |doi=10.1097/01.mcg.0000168638.84840.ff |url=}}</ref><ref name="pmid16447287">{{cite journal |vauthors=Farrell GC, Larter CZ |title=Nonalcoholic fatty liver disease: from steatosis to cirrhosis |journal=Hepatology |volume=43 |issue=2 Suppl 1 |pages=S99–S112 |year=2006 |pmid=16447287 |doi=10.1002/hep.20973 |url=}}</ref> | |||
**[[Obesity]] | |||
**[[Insulin resistance]]/[[Diabetes mellitus type 2|type 2 diabetes]] | |||
**[[Hypertension]] | |||
**[[Hyperlipoproteinemia|Hyperlipidemia]] | |||
==References== | ==References== | ||
{{reflist|2}} | |||
[[Category:Gastroenterology]] | |||
[[Category:Hepatology]] | |||
[[Category:Disease]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 18:25, 27 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Sudarshana Datta, MD [3]
Overview
Lifestyle and genetic risk factors play an important role in the development of cirrhosis in patients. Chronic alcohol use, chronic hepatitis B and C infection and genetic diseases such as cystic fibrosis are also significant risk factors for the development of cirrhosis.
Risk Factors
The risk factors of cirrhosis are as follows:
- Chronic alcohol abuse: regular moderate alcohol consumption is the most common cause of cirrhosis in the United States and other western countries[1]
- Chronic Hepatitis B and C viruses: most common cause of cirrhosis in Asian countries
- Autoimmune hepatitis
- Chronic blockage of the bile duct
- Wilson's Disease
- hemochromatosis
- Cystic fibrosis
- Alpha l-antitrypsin deficiency
- Nonalcoholic fatty liver disease
- Prolonged exposure to drugs and toxins
- Age above 50 years [2]
- Male gender [3]
- Features of metabolic syndrome in Non Alcoholic Steato Heaptitis(NASH): [4][5]
References
- ↑ Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Crocè L, Sasso F, Pozzato G, Cristianini G, Brandi G (1997). "Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group". Gut. 41 (6): 845–50. PMC 1891602. PMID 9462221.
- ↑ Poynard T, Bedossa P, Opolon P (1997). "Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups". Lancet. 349 (9055): 825–32. PMID 9121257.
- ↑ Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Crocè LS, Mazzoran L, Masutti F, Cristianini G, Tiribelli C (1999). "Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study". Gut. 44 (6): 874–80. PMC 1727553. PMID 10323892.
- ↑ Clark JM (2006). "The epidemiology of nonalcoholic fatty liver disease in adults". J. Clin. Gastroenterol. 40 Suppl 1: S5–10. doi:10.1097/01.mcg.0000168638.84840.ff. PMID 16540768.
- ↑ Farrell GC, Larter CZ (2006). "Nonalcoholic fatty liver disease: from steatosis to cirrhosis". Hepatology. 43 (2 Suppl 1): S99–S112. doi:10.1002/hep.20973. PMID 16447287.