Chronic pancreatitis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]

Overview

The incidence of chronic pancreatitis and the number of hospital admissions is increasing in most countries worldwide. The incidence of chronic pancreatitis is approximately 1.6 to 23 cases per 100,000 individuals per year worldwide. A rising level of per capita alcohol consumption is correlated with an increasing prevalence of chronic pancreatitis. Changes in lifestyle modifications such as smoking and alcohol cessation may result in slowing the progression and reducing the incidence of chronic pancreatitis. Alcoholic pancreatitis is more prevalent in developed or industrialized countries. Idiopathic and tropical pancreatitis is more prevalent in developing and underdeveloped countries.

Epidemiology and Demographics

Incidence

  • In 2004, the incidence of chronic pancreatitis was estimated to be 8.1 per 100,000 individuals in the United States of America.[1]
  • The incidence of chronic pancreatitis is approximately 1.6 to 23 cases per 100,000 individuals per year worldwide.
  • In United States, chronic pancreatitis results in:
    • >122,000 outpatient visits per year.
    • >56,000 hospitalizations per year.
  • The incidence of chronic pancreatitis and the number of hospital admissions is increasing in most countries worldwide.
  • Changes in lifestyle modifications such as smoking and alcohol cessation may result in slowing the progression and reducing the incidence of chronic pancreatitis.

Prevalence

  • A rising level of per capita alcohol consumption is correlated with an increasing prevalence of chronic pancreatitis.

Age

Gender

  • Men and women are almost equally affected in the United States.[1][7][8]
  • Men are more commonly affected by chronic pancreatitis than females in almost all countries except the United States.[9][10][11][12] [13][5][6][14][15]

Developed countries

  • Alcoholic pancreatitis is more prevalent in developed or industrialized countries.

Developing countries

  • Idiopathic and tropical pancreatitis is more prevalent in developing and underdeveloped countries.

References

  1. 1.0 1.1 Yang AL, Vadhavkar S, Singh G, Omary MB (2008). "Epidemiology of alcohol-related liver and pancreatic disease in the United States". Arch. Intern. Med. 168 (6): 649–56. doi:10.1001/archinte.168.6.649. PMID 18362258.
  2. Lévy P, Barthet M, Mollard BR, Amouretti M, Marion-Audibert AM, Dyard F (2006). "Estimation of the prevalence and incidence of chronic pancreatitis and its complications". Gastroenterol. Clin. Biol. 30 (6–7): 838–44. PMID 16885867.
  3. Frulloni L, Gabbrielli A, Pezzilli R, Zerbi A, Cavestro GM, Marotta F, Falconi M, Gaia E, Uomo G, Maringhini A, Mutignani M, Maisonneuve P, Di Carlo V, Cavallini G (2009). "Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients". Dig Liver Dis. 41 (4): 311–7. doi:10.1016/j.dld.2008.07.316. PMID 19097829.
  4. Lowenfels AB, Maisonneuve P, Grover H, Gerber E, Korsten MA, Antunes MT, Marques A, Pitchumoni CS (1999). "Racial factors and the risk of chronic pancreatitis". Am. J. Gastroenterol. 94 (3): 790–4. doi:10.1111/j.1572-0241.1999.00952.x. PMID 10086667.
  5. 5.0 5.1 Pezzilli R, Morselli-Labate AM, Fantini L, Campana D, Corinaldesi R (2007). "Assessment of the quality of life in chronic pancreatitis using Sf-12 and EORTC Qlq-C30 questionnaires". Dig Liver Dis. 39 (12): 1077–86. doi:10.1016/j.dld.2007.06.014. PMID 17692582.
  6. 6.0 6.1 Wehler M, Nichterlein R, Fischer B, Farnbacher M, Reulbach U, Hahn EG, Schneider T (2004). "Factors associated with health-related quality of life in chronic pancreatitis". Am. J. Gastroenterol. 99 (1): 138–46. PMID 14687155.
  7. 7.0 7.1 Whitcomb DC, Yadav D, Adam S, Hawes RH, Brand RE, Anderson MA, Money ME, Banks PA, Bishop MD, Baillie J, Sherman S, DiSario J, Burton FR, Gardner TB, Amann ST, Gelrud A, Lo SK, DeMeo MT, Steinberg WM, Kochman ML, Etemad B, Forsmark CE, Elinoff B, Greer JB, O'Connell M, Lamb J, Barmada MM (2008). "Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2)". Pancreatology. 8 (4–5): 520–31. doi:10.1159/000152001. PMC 2790781. PMID 18765957.
  8. Tao N, Sussman S, Nieto J, Tsukamoto H, Yuan JM (2003). "Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county". Alcohol. Clin. Exp. Res. 27 (11): 1798–804. doi:10.1097/01.ALC.0000095862.30777.D9. PMID 14634496.
  9. Lankisch PG, Assmus C, Maisonneuve P, Lowenfels AB (2002). "Epidemiology of pancreatic diseases in Lüneburg County. A study in a defined german population". Pancreatology. 2 (5): 469–77. doi:10.1159/000064713. PMID 12378115.
  10. Jaakkola M, Nordback I (1993). "Pancreatitis in Finland between 1970 and 1989". Gut. 34 (9): 1255–60. PMC 1375465. PMID 8406164.
  11. Wang LW, Li ZS, Li SD, Jin ZD, Zou DW, Chen F (2009). "Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years". Pancreas. 38 (3): 248–54. doi:10.1097/MPA.0b013e31818f6ac1. PMID 19034057.
  12. Bourliere M, Barthet M, Berthezene P, Durbec JP, Sarles H (1991). "Is tobacco a risk factor for chronic pancreatitis and alcoholic cirrhosis?". Gut. 32 (11): 1392–5. PMC 1379175. PMID 1752475.
  13. Cavallini G, Frulloni L, Pederzoli P, Talamini G, Bovo P, Bassi C, Di Francesco V, Vaona B, Falconi M, Sartori N, Angelini G, Brunori MP, Filippini M (1998). "Long-term follow-up of patients with chronic pancreatitis in Italy". Scand. J. Gastroenterol. 33 (8): 880–9. PMID 9754738.
  14. Garg PK, Tandon RK (2004). "Survey on chronic pancreatitis in the Asia-Pacific region". J. Gastroenterol. Hepatol. 19 (9): 998–1004. doi:10.1111/j.1440-1746.2004.03426.x. PMID 15304116.
  15. Balakrishnan V, Unnikrishnan AG, Thomas V, Choudhuri G, Veeraraju P, Singh SP, Garg P, Pai CG, Devi RN, Bhasin D, Jayanthi V, Premalatha N, Chacko A, Kar P, Rai RR, Rajan R, Subhalal N, Mehta R, Mishra SP, Dwivedi M, Vinayakumar KR, Jain AK, Biswas K, Mathai S, Varghese J, Ramesh H, Alexander T, Philip J, Raj VV, Vinodkumar A, Mukevar S, Sawant P, Nair P, Kumar H, Sudhindran S, Dhar P, Sudheer OV, Sundaram KR, Tantri BV, Singh D, Nath TR (2008). "Chronic pancreatitis. A prospective nationwide study of 1,086 subjects from India". JOP. 9 (5): 593–600. PMID 18762690.


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